NCT06745089

Treatment Effect of Intense Pulsed Light and Thermal Pulsation Therapy on Meibomian Gland Dysfunction-associated Dry Eye Disease: a Randomized Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 45 (actual)
• Sponsor: National Yang Ming Chiao Tung University · Academic / Other
• Sex: All
• Age: 20 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

The goal of this clinical trial is to understand novel treatment methods for meibomian gland dysfunction (MGD)-associated dry eye disease (DED) by comparing two treatment modalities- intense pulsed light (IPL) and thermal pulsation therapy (TPT), to find out the difference of their therapeutic mechanisms and treatment effects, so that eye doctors can give more precise advice to the patients when making treatment decisions. The main questions it aims to answer are: * What subtype of meibomian gland dysfunction (MGD) better responds to which treatment modality? * How long do the treatment effects last? Researchers will compare each group (IPL and TPT) to a control group treated with eyedrops. \* Do combined treatment of IPL or TPT with eyedrops show better outcomes than only eyedrops? Participants will: * Receive different treatment for 2 months according to the group they were randomly allocated to. * Visit the clinic for checkups after 1 and 3 months after completing the treatment sessions.

Conditions

• Dry Eye Disease (DED)
• Meibomian Gland Dysfunction

Interventions

Type	Name	Description
DEVICE	Intense pulsed light	Intense pulsed light exerts photothermal, photochemical effects, and photobiomodulation on meibomian glands.
DEVICE	thermal pulsation therapy	Thermal pulsation therapy utilizes local heating and massage on the eyelids.
DRUG	Ocular lubricant	Ocular lubricants moisturize the ocular surface.

Timeline

• Start date: 2022-07-13
• Primary completion: 2023-06-21
• Completion: 2024-03-10
• First posted: 2024-12-20
• Last updated: 2024-12-20

Locations

1 site across 1 country: Taiwan