| Not Yet Recruiting | Effect of Behavioral Intervention (Baduanjin Alone or Laughter Exercise Plus Artificial Tears) Versus Artifici NCT07524725 | Zhongshan Ophthalmic Center, Sun Yat-sen University | N/A |
| Not Yet Recruiting | A Prospective, Multicenter, Randomized Controlled Trial to Evaluate the Efficacy and Safety of Amnion Membrane NCT07529899 | Cellution Biologics | Phase 3 |
| Not Yet Recruiting | An Exploratory Efficacy and Safety Study of DFL24498 Topical Ophthalmic Solution Compared With Vehicle in Part NCT07503886 | Dompé Farmaceutici S.p.A | Phase 2 |
| Not Yet Recruiting | Evaluation of Allogenic Mesenchymal Stem Cell (MSC) Injection Therapy for Refractory Graft-versus-Host Disease NCT06905834 | Instituto de Investigación Biomédica de Salamanca | Phase 2 |
| Not Yet Recruiting | Effect of Dry Eye Disease on Accuracy of Intraocular Lens Power Calculation Before Phacoemulsification NCT07525336 | Assiut University | — |
| Not Yet Recruiting | Comparison of Conjunctival Goblet Cell Density in Dry Eye Patients Treated With Cyclosporine 0.1% Dissolved in NCT07368595 | Baylor College of Medicine | Phase 4 |
| Not Yet Recruiting | Safety and Efficacy of Kelulut Honey Eyedrops in Dry Eye Disease NCT07279324 | Universiti Sains Malaysia | N/A |
| Not Yet Recruiting | Rebamipide Versus Diquafosol for Perioperative Dry Eye in Cataract Surgery NCT07397949 | Samsung Medical Center | Phase 4 |
| Not Yet Recruiting | BriTer Eyez Moisture Vue™ On-Demand Disposable Moisture Chamber NCT07430735 | University of Rochester | Phase 1 |
| Recruiting | SYSTANE® PRO vs. MIEBO™ in Dry Eye Disease NCT07243275 | Indiana University | Phase 4 |
| Not Yet Recruiting | Efficacy and Safety of VMX Eye Drops for Dry Eye Disease NCT07369375 | VISUfarma SpA | N/A |
| Recruiting | A Non-interventional Study to Evaluate the Anti-inflammatory Effects and the Clinical Efficacy of Topical Wate NCT07463950 | Medical University of Vienna | Phase 4 |
| Recruiting | Supplementary Kelulut Honey Therapy in Juvenile Open-Angle Glaucoma: Effects on IL-6, RNFL and Dry Eye NCT07396441 | Universiti Sains Malaysia | Phase 4 |
| Not Yet Recruiting | Telemedicine for Evaluating Dry Eye Disease (DED) Using a Mobile Phone-Attached Portable Automatic Ocular Surf NCT07341724 | Singapore National Eye Centre | N/A |
| Not Yet Recruiting | Non-interventional Study to Evaluate the Anti-inflammatory Effects and the Clinical Efficacy of Topical Water NCT07234318 | Laboratoires Thea | — |
| Not Yet Recruiting | Investigator Initiated Trial Using Dry Eye Surveys to Evaluate and Better Understand FDA Approved Acoltremon T NCT07281950 | Center for Sight Las Vegas | Phase 4 |
| Not Yet Recruiting | A Dose Regimen Study of BRM421 Ophthalmic Solution in Patients With Dry Eye Disease NCT07078955 | BRIM Biotechnology Inc. | Phase 2 |
| Enrolling By Invitation | Moderate-to-Severe Dry Eye Disease Relief Using Acoltremon NCT07268599 | Colvard Kandavel Eye Center | — |
| Recruiting | New Preservative-free Combination of Trehalose, Sodium Hyaluronate and N-acetyl-aspartyl-glutamate (NAAGA) in NCT06903741 | Laboratoires Thea | Phase 4 |
| Completed | Effect of a Dietary Supplement on Gut Microbiota and Ocular Surface Outcomes in Dry Eye Disease NCT07148271 | Varol TUNALI | N/A |
| Recruiting | Evaluating Crosslinked Hyaluronate Canalicular Gel for the Treatment of DED in Patients Undergoing Cataract Su NCT07155057 | Vance Thompson Vision | N/A |
| Not Yet Recruiting | The Effects of 3% Trehalose Ophthalmic Solution on Corneal Epithelial Barrier Function NCT06655441 | Southern California College of Optometry at Marshall B. Ketchum University | Phase 4 |
| Not Yet Recruiting | A Study Evaluating the Efficacy and Safety of RCI001 Ophthalmic Solution Compared to Placebo in Subjects With NCT07068958 | ORA, Inc. | Phase 2 |
| Enrolling By Invitation | Effect of Low-Level Light Therapy on Ocular Surface Parameters in Patients With Graves Disease NCT07332988 | Grigore T. Popa University of Medicine and Pharmacy | N/A |
| Not Yet Recruiting | Correlation of Dry Eye Disease, Problematic Smartphone Use and Sleep Quality in Adolescents and Young Adults NCT07020871 | Wei XIA, PhD | — |
| Not Yet Recruiting | Impact of DED on the Accuracy of Preoperative Keratometry Values in the Calculation of IOL Power for Cataract NCT06989827 | University Hospital Sestre Milosrdnice | N/A |
| Active Not Recruiting | Clinical Efficacy and Molecular Dynamics of Quantum Molecular Resonance (QMR) Electrotherapy in Dry Eye Manage NCT06955806 | The Hong Kong Polytechnic University | N/A |
| Not Yet Recruiting | The Effect of 0.1% Topical Ciclosporin A for 12-weeks on the Eye Surface Immune Cells in Dry Eyes NCT06898853 | The University of New South Wales | N/A |
| Recruiting | Clinical Investigation Between the Topical Administration of a Tear Substitute With Ancillary Medicinal Substa NCT07412860 | FB Vision S.p.A | N/A |
| Recruiting | Telemedicine Evaluation of Dry Eye Disease Using a Portable Automatic Ocular Surface Imaging Device (PAOSID) NCT06984549 | Chen Wei | — |
| Recruiting | Role of Corneal Nerves in Dry Eye Disease NCT06841471 | Daniela Nosch | — |
| Completed | Anti-inflammatory Effects and Clinical Efficacy of Topical Thealoz Total Eye Drops in Patients With Chronic Dr NCT07007702 | Laboratoires Thea | — |
| Completed | Anti-inflammatory Effects and Clinical Efficacy of Topical Thealoz Total Eye Drops in Patients With Chronic Dr NCT07245836 | Medical University of Vienna | Phase 4 |
| Completed | A Study in the Treatment of Mild to Moderate Dry Eye Disease Comparing Saline to TTAX03. NCT06780306 | BioTissue Holdings, Inc | Phase 2 |
| Completed | Tear Film Stability and Improvement of Asthenopia: Efficacy Observation of 0.05% Cyclosporine in Dry Eye Patie NCT06981104 | Second Affiliated Hospital, School of Medicine, Zhejiang University | N/A |
| Not Yet Recruiting | Clinical Study Aimed At Evaluating the Safety and Efficacy of Tear Substitute Formulations in the Treatment of NCT06633471 | PS Therapy Inc. | EARLY_Phase 1 |
| Completed | Efficacy of Pilocarpine As a Secretagogue Versus Artificial Tears for the Treatment of Dry Eye NCT06752278 | Al-Azhar University | N/A |
| Not Yet Recruiting | Using Dry Eye As a Disease Model, Investigators Demonstrated the Optimal Selection of Individualized Clinical NCT06605495 | Xuejing Lu | N/A |
| Recruiting | Impact of Tixel Treatment on Symptoms and Signs in Patients With Dry Eye Disease NCT06615453 | Aston University | N/A |
| Enrolling By Invitation | Efficacy of 0.28% Sodium Hyaluronate Eye Drops in Patient With Moderate to Severe Dry Eye NCT06860659 | Department of Medical Services Ministry of Public Health of Thailand | Phase 4 |
| Completed | Rebamipide Versus Diquafosol and Cyclosporine for Perioperative Dry Eye in Cataract Surgery NCT07397936 | Samsung Medical Center | Phase 4 |
| Completed | Effect of Smart Phone Reflective Light Film on Dry Eyes and Asthenopia NCT06992635 | Second Affiliated Hospital, School of Medicine, Zhejiang University | N/A |
| Completed | Photobiomodulation in Combination With Topical Cyclosporine A or Tacrolimus NCT07239128 | University of Seville | EARLY_Phase 1 |
| Recruiting | Phase III Clinical Study of Lifitegrast Ophthalmic Solution for the Treatment of Dry Eye Disease NCT06879782 | Lunan Better Pharmaceutical Co., LTD. | Phase 3 |
| Recruiting | Observe the Effects of Far Infrared Eye Masks on Acupoints Around the Eyes in Patients With Dry Eye Syndrome NCT07060131 | China Medical University Hospital | N/A |
| Completed | Vizol S DIGI EYE Efficacy and Safety Study in Patients With Dry Eye NCT07050446 | Jadran Galenski laboratorij d.d. | Phase 3 |
| Completed | Effects of NOV03 on the Tear Film NCT05723770 | Bausch & Lomb Incorporated | Phase 4 |
| Completed | Clinical and Biological Evaluation of NAAGA Versus Azelastine Eye Drops in Allergic Subjects With Tear Film Dy NCT06800274 | Azienda Ospedaliera OO.RR. S. Giovanni di Dio e Ruggi D'Aragona | Phase 4 |
| Completed | Immediate Therapeutic Effects of Diquafosol and Rebamipide in Dry Eye Disease NCT07297316 | Korea University Anam Hospital | Phase 4 |
| Completed | Once-daily Fluorometholone vs Twice-daily Cyclosporine in Dry Eye Disease NCT06876116 | Korea University Anam Hospital | Phase 4 |
| Completed | Treatment Effect of Intense Pulsed Light and Thermal Pulsation Therapy on Meibomian Gland Dysfunction-associat NCT06745089 | National Yang Ming Chiao Tung University | N/A |
| Completed | Cross-linked CMC and Silk Proteins in Eye Disease NCT06605365 | D&V FARMA srl | — |
| Completed | Ophthalmic Solution in Diabetic Corneal Alteration NCT06573606 | D&V FARMA srl | — |
| Completed | CyclASol for the Treatment of Signs and Symptoms of Dry Eye Disease in Subjects Who Completed CYS-004 NCT04523142 | Novaliq GmbH | Phase 3 |
| Recruiting | Proteomics Analysis of Human Tears in the Diagnosis and Management of Dry Eye Disease NCT07175909 | The Hong Kong Polytechnic University | N/A |
| Completed | Long-Term Safety and Tolerability of NOV03 (Perfluorohexyloctane) in Subjects Who Completed Trial NVU-003 (Kal NCT04140227 | Bausch & Lomb Incorporated | Phase 3 |
| Completed | Perfluorohexylcotane (NOV03) for the Treatment of Signs and Symptoms of Dry Eye Disease Associated With Meibom NCT04139798 | Bausch & Lomb Incorporated | Phase 3 |
| Completed | Efficacy and Safety of a New Artificial Tear Formulation Compared With Systane Ultra Multidose in Participants NCT04393441 | Allergan | Phase 3 |
| Completed | Evaluation of the Efficacy and Safety of OC-01 Nasal Spray on Signs and Symptoms of Dry Eye Disease NCT04036292 | Oyster Point Pharma, Inc. | Phase 3 |
| Completed | Perfluorohexyloctane (NOV03) for the Treatment of Signs and Symptoms of Dry Eye Disease (DED) NCT03333057 | Novaliq GmbH | Phase 2 |
| Completed | Phase 3 Study of EBI-005 in Dry Eye Disease NCT01998802 | Eleven Biotherapeutics | Phase 3 |