NCT06981104

Tear Film Stability and Improvement of Asthenopia: Efficacy Observation of 0.05% Cyclosporine in Dry Eye Patients With Short BUT

A Randomized, Double-blind, Controlled Clinical Study on the Efficacy and Safety of 0.05% Cyclosporine Eye Drops in the Treatment of Mild to Moderate Dry Eye

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

At present, research on cyclosporine mainly focuses on patients with moderate to severe dry eye. Based on the importance of the vicious cycle of inflammation in the pathogenesis of dry eye and the mechanism of cyclosporine, investigators believe that it may also have therapeutic effects in patients with mild to moderate dry eye, and may have certain advantages compared to traditional artificial tear therapy. In summary, this study intends to use a randomized, double-blind, parallel controlled trial to evaluate the therapeutic efficacy and safety of 0.05% cyclosporine eye drops in patients with mild to moderate dry eyes.

Conditions

• Dry Eye Disease (DED)
• Asthenopia

Interventions

Type	Name	Description
DRUG	0.05% cyclosporine eyedrops	0.05% cyclosporine, one drop each time, twice a day
DRUG	0.1% sodium hyaluronate eye drop	0.1% sodium hyaluronate, one drop each time, three times a day

Timeline

• Start date: 2024-11-18
• Primary completion: 2025-02-14
• Completion: 2025-02-14
• First posted: 2025-05-20
• Last updated: 2025-11-20

Locations

1 site across 1 country: China