| Recruiting | Safety and Tolerability Study of a Novel Bioartificial Liver in Liver Failure and Small-for-Size Syndrome NCT07312864 | Beijing Friendship Hospital | Phase 1 / Phase 2 |
| Recruiting | The Microbiota Augmentation to Reestablish Commensal Organisms (MARCO) Trial NCT06871111 | University of Chicago | Phase 1 |
| Recruiting | CRISPR-Edited HLA Donor Liver Transplant to Reduce Rejection NCT07053488 | AMERICAN ORGAN TRANSPLANT AND CANCER RESEARCH INSTITUTE LLC | Phase 1 / Phase 2 |
| Not Yet Recruiting | MSC-EVs in Acute/ Acute-on-Chronic Liver Failure After Liver Transplantation NCT06825572 | Third Affiliated Hospital, Sun Yat-Sen University | Phase 1 |
| Not Yet Recruiting | Study of Oxidized Albumin in Liver Transplant Patients NCT06772298 | Region Stockholm | — |
| Recruiting | Efficacy and Safety of Citrate Anticoagulation in CRRT for Patients With Liver Failure/DysfuncTION, the CAUTIO NCT06908746 | University Hospital, Antwerp | — |
| Recruiting | Predictive Values of Presepsin Levels in ASciteS in Patients With Chronic Liver Failure NCT06224023 | Carol Davila University of Medicine and Pharmacy | — |
| Recruiting | Safety and Effectiveness of Mesenchymal Stem Cells in Blood Purification for the Treatment of Liver Failure NCT06904755 | Kebo Zhong | Phase 1 |
| Completed | Modified Thoracoabdominal Nerve Plane Block In Living Liver Donors NCT06300372 | Istanbul Medipol University Hospital | N/A |
| Not Yet Recruiting | A Multicenter Prospective Clinical Cohort Study on the Pathogen Spectrum of Severe Hepatitis (Liver Failure) C NCT06272071 | Zhejiang University | — |
| Unknown | Quantitative MRI and Outcomes of Liver Resection NCT06181318 | University Hospital Heidelberg | — |
| Recruiting | Clinical Retrospective Study Analysis of Postoperative Complications Following Hepatectomy NCT06532214 | Nanfang Hospital, Southern Medical University | — |
| Unknown | Alterations in Coagulation Factor Levels in Patients With End Stage Liver Disease NCT06014320 | Stanford University | — |
| Recruiting | The Safety ,Tolerability and Efficacy Study of HepaCure in Chinese Subjects with Acute-On-Chronic Liver Failur NCT05989958 | Hexaell Biotech Co., Ltd. | Phase 1 / Phase 2 |
| Recruiting | Empagliflozin in Patients With Cirrhosis and Ascites NCT05726032 | Yale University | Phase 2 |
| Recruiting | Assessment of the Pharmacokinetic Profile of Tacrolimus Medications and Their Relation to Effectiveness and Sa NCT05744635 | Chiesi Hungary Ltd. | — |
| Recruiting | Registry Study for Optimal Management of Liver Failure in the Chinese Population NCT05740696 | First Affiliated Hospital Xi'an Jiaotong University | — |
| Recruiting | A Study on Relationship Between Resected Normal Liver Parenchymal Volume（RNLV）and Post-Hepatectomy Liver Failu NCT06366048 | National Natural Science Foundation of China | — |
| Terminated | Evaluation of the Efficacy of Fomepizole in the Treatment of Acetaminophen Overdose NCT05517668 | Richard Dart, MD, PhD | Phase 2 |
| Recruiting | Efficacy and Safety of ALSS Treatment for ICIs-LF in Patients With HCC NCT05484908 | Third Affiliated Hospital, Sun Yat-Sen University | N/A |
| Unknown | Intravenous Ketamine Infusion on Postoperative Analgesia of Living Liver Donors NCT05441150 | Inonu University | Phase 4 |
| Completed | Continuous Renal Replacement Therapy (CRRT) in Surgery Room During Orthotopic Liver Transplantation (OLT) NCT06844435 | IRCCS Azienda Ospedaliero-Universitaria di Bologna | N/A |
| Unknown | Pharmacokinetic Study of Continuous Infusion of Remazolam in Mechanically Ventilated Patients in ICU NCT05480787 | The First Affiliated Hospital with Nanjing Medical University | Phase 4 |
| Active Not Recruiting | Safety and Clinical Activity of QEL-001 in A2-mismatch Liver Transplant Patients NCT05234190 | Quell Therapeutics Limited | Phase 1 / Phase 2 |
| Completed | Bridge to HOPE: Hypothermic Oxygenated Perfusion Versus Cold Storage Prior to Liver Transplantation NCT05045794 | Bridge to Life Ltd. | N/A |
| Completed | Gd-EOB-DTPA-enhanced T1 Map for Predicting Postoperative Liver Failure NCT05592106 | Shanghai Zhongshan Hospital | — |
| Withdrawn | Branched-chain Amino Acid Supplementation for Hepatocellular Carcinoma NCT03908255 | Louisiana State University Health Sciences Center in New Orleans | Phase 2 |
| Recruiting | Fecal Microbiota Transplantation for Liver Failure NCT05170971 | Ningbo Medical Center Lihuili Hospital | N/A |
| Recruiting | Study of Sacituzumab Govitecan in Participants With Advanced or Metastatic Solid Tumor and Moderate Liver Impa NCT04617522 | Gilead Sciences | Phase 1 |
| Completed | Mortality, Morbidity and Risk Factors of Liver Retransplantation NCT04789213 | Memorial Bahçelievler Hospital | — |
| Recruiting | Effects of the SGLT2 Inhibitor Empagliflozin in Patients With Euvolemic and Hypervolemic Hyponatremia NCT04447911 | University Hospital, Basel, Switzerland | Phase 4 |
| Unknown | Avatrombopag in Patients With End-stage Liver Disease and Thrombocytopenia NCT04906083 | Tongji Hospital | Phase 4 |
| Completed | SELF-BREATHE RCT for Chronic Breathlessness NCT04574050 | King's College Hospital NHS Trust | N/A |
| Completed | Intraoperative Hemodynamic Management and Postoperative Outcomes in Liver Transplantation NCT04732689 | Centre hospitalier de l'Université de Montréal (CHUM) | — |
| Completed | Biliary Anastomosis Using Surgical Loupe Versus Microscope in Living Donor Liver Transplantation NCT04618692 | Istanbul Medipol University Hospital | N/A |
| Completed | Meals MATTER: A Trial of Medically Tailored Meals 2 Weeks vs. 4 Weeks Post Hospital Discharge NCT04351880 | Kaiser Permanente | N/A |
| Unknown | ARAPS Study on Accelerated Liver Regeneration NCT04107324 | University of Aarhus | N/A |
| Completed | Evaluation of HDL Subfraction Changes and HDL-Associated Enzymes in Liver Failure Patients and Healthy Donors NCT05958420 | Akdeniz University | — |
| Terminated | Early Cycle Ergometry for Critically-Ill Liver Failure Patients in a Transplant Intensive Care Unit NCT04160039 | Medical College of Wisconsin | N/A |
| Unknown | The Effect of Terlipressin on Recovery of Liver Function After Hepatectomy NCT04221672 | Shanghai Zhongshan Hospital | Phase 3 |
| Unknown | Hepatectomy Risk Assessment With Functional Magnetic Resonance Imaging NCT04705194 | University of Leeds | — |
| Completed | Monitoring the HePAtological TOXicity of Drugs (HePATOX) NCT03833297 | Groupe Hospitalier Pitie-Salpetriere | — |
| Unknown | The Efficacy and Safety of Nucleos(t)Ide Analogues in the Treatment of HBV-related Acute-on-chronic Liver Fail NCT03640728 | First Affiliated Hospital Xi'an Jiaotong University | — |
| Completed | Nomogram Analysis for HBV Related Acute-on-chronic Liver Failure NCT03992898 | Sun Yat-sen University | — |
| Unknown | RCA for CRRT in Liver Failure and High Risk Bleeding Patients NCT03791190 | Air Force Military Medical University, China | N/A |
| Completed | Hepatitis C Virus (HCV) Positive Liver Grafts in HCV Negative Recipients NCT03650920 | Loma Linda University | N/A |
| Unknown | A Prospective Randomized Controlled Trial on the Use of Cerebral Oximetry in Adult Chinese Patients Undergoing NCT04122027 | The University of Hong Kong | N/A |
| Unknown | Liver Stiffness Measurement (LSM) in Predicting Progress of Liver Fibrosis After TACE for Hepatocellular Carci NCT03285867 | Nanfang Hospital, Southern Medical University | — |
| Unknown | Plasma Exchange and Continuous Hemodiafiltration in Treatment of Wilson's Disease-related Liver Failure NCT03589820 | Third Affiliated Hospital, Sun Yat-Sen University | N/A |
| Terminated | BRIDGE Device for Post-operative Pain Control NCT03265249 | Duke University | N/A |
| Completed | Associated Balance of Risk Score - Comprehensive Complication Index for the Prediction of Post-transplant Surv NCT03723317 | European Hepatocellular Cancer Liver Transplant Group | — |
| Completed | The Efficacy and Safety of Thymosin-α1 in Patients With HBV-related ACLF NCT03082885 | Sun Yat-sen University | N/A |
| Completed | Telemedicine Based Remote Home Monitoring After Liver Transplantation NCT03878329 | University of Cincinnati | N/A |
| Unknown | Comparative Study of Circulating microRNA Changes in Patients With Liver Injury and Healthy Subjects NCT03000621 | University of Electronic Science and Technology of China | — |
| Withdrawn | Transfer Factor Efficacy in the Management of Cirrhosis-associated Immune Dysfunction NCT02837939 | Martin Janičko | Phase 2 / Phase 3 |
| Completed | Superior Vena Cava and Its Relationship to Central Venous Pressure Measurements in Liver Transplantation NCT02818218 | The Cleveland Clinic | — |
| Unknown | UC-MSC Infusion for HBV-Related Acute-on-Chronic Liver Failure NCT02812121 | Sun Yat-sen University | Phase 2 |
| Completed | Lipid Emulsions and Liver Function - Results After 5 Years. NCT04347902 | Stanley Dudrick's Memorial Hospital | Phase 4 |
| Completed | Dual Hypothermic Oxygenated Perfusion of DCD Liver Grafts in Preventing Biliary Complications After Transplant NCT02584283 | Robert J. Porte | Phase 3 |
| Completed | A Randomized Controlled Clinical Trial of Thymoglobulin® After Liver Transplantation NCT02544113 | The Cleveland Clinic | Phase 2 |
| Completed | Comparative Analysis of Different Tests to Evaluate Prognosis of Patients on Liver Transplant Waiting List NCT01774617 | Guilherme Rezende | — |
| Withdrawn | Cardiox Liver Function Test Pivotal Trial NCT02552901 | Cardiox Corporation | Phase 3 |
| Completed | Remote Ischemic Conditioning (RIC) in Recipients of Brain Death Donor Livers - A Feasibility and Safety Study NCT02635347 | Rutgers, The State University of New Jersey | N/A |
| Completed | Mobilization of Mesenchymal Stem Cells During Liver Transplantation NCT02557724 | Rutgers, The State University of New Jersey | — |
| Completed | MERTK Signalling in Monocytes/Macrophages in Patients With Liver Disease NCT04116242 | University Hospital, Basel, Switzerland | — |
| Unknown | The Effect of Somatostatin for Treatment of Post Hepatectomy Liver Failure (PHLF) NCT02882347 | Korea University Anam Hospital | Phase 3 |
| Unknown | Pneumatic Reversible Portal Vein Diameter Modulation After Major Hepatectomy NCT02390713 | Assistance Publique - Hôpitaux de Paris | Phase 1 / Phase 2 |
| Completed | Comparative FK506 Drug Levels of Once Daily Advagraf in First Nations and Caucasian Patients With Liver Transp NCT04237246 | University of Manitoba | Phase 4 |
| Terminated | NIRS as a Continuous Noninvasive Monitoring System of Liver/Kidney Graft Perfusion NCT02343016 | Mariella Enoc | — |
| Completed | Renal Perfusion, Filtration and Oxygenation After Liver Transplantation -Effects of av Postoperative Blood Pre NCT02455115 | Sahlgrenska University Hospital | N/A |
| Completed | Single-Cell and Spatial Transcriptomics Analysis of Steatotic Donor Liver Susceptibility to Post-Transplant In NCT07362745 | Xijing Hospital | — |
| Completed | NOninVasive Intracranial prEssure From Transcranial doppLer Ultrasound Development of a Comprehensive Database NCT04548596 | Emory University | — |
| Completed | The Relationship of Initial Liver Profile and Outcome After Transplantation NCT02307890 | University of Edinburgh | — |
| Withdrawn | Hepatocyte Transplantation in Liver Failure NCT00805610 | Virginia Commonwealth University | Phase 1 / Phase 2 |
| Completed | Single-Dose Pharmacokinetics and Safety of Oral Lofexidine in Hepatically-Impaired Subjects NCT02318836 | USWM, LLC (dba US WorldMeds) | Phase 1 |
| Terminated | Terlipressin Administration in Patients Undergoing Major Liver Resection NCT01921985 | Insel Gruppe AG, University Hospital Bern | Phase 2 |
| Unknown | Prognosis Scoring System for Acute-on-Chronic Liver Failure NCT01961440 | Third Affiliated Hospital, Sun Yat-Sen University | — |
| Unknown | RCT Study on Granulocyte Colony-stimulating Factor(G-CSF) Treatment of Hepatic Failure NCT02331745 | Beijing 302 Hospital | Phase 4 |
| Unknown | Safety and Efficacy of Diverse Mesenchymal Stem Cells Transplantation for Liver Failure NCT01844063 | Third Affiliated Hospital, Sun Yat-Sen University | Phase 1 / Phase 2 |
| Completed | Unknown Cause of Acute Liver Failure NCT02041637 | Assistance Publique - Hôpitaux de Paris | — |
| Completed | Fast-track LiveR: Study for the Early Identification of Low-risk Patients After Partial Liver Resection by the NCT01785082 | Humedics GmbH | Phase 3 |
| Unknown | Umbilical Cord Mesenchymal Stem Cells Transplantation Combined With Plasma Exchange for Patients With Liver Fa NCT01724398 | Third Affiliated Hospital, Sun Yat-Sen University | Phase 1 / Phase 2 |
| Unknown | A Trial of Ribavirin in Patients With ACLF Due to Hepatitis E Virus NCT01698723 | All India Institute of Medical Sciences | Phase 2 |
| Unknown | Lactate Clearance According to the Presence of Hepatic Dysfunction NCT01709565 | Samsung Medical Center | — |
| Unknown | Randomized Trial of Hepaticojejunostomy Versus Duct-to-duct Anastomosis in Right Lobe Living Donor Liver Trans NCT04139473 | The University of Hong Kong | N/A |
| Terminated | Intraoperative Dialysis in Liver Transplantation NCT01575015 | University of Alberta | N/A |
| Completed | Mesenchymal Stem Cells After Renal or Liver Transplantation NCT01429038 | University of Liege | Phase 1 / Phase 2 |
| Unknown | Cerebrovascular Autoregulation During and After Liver Transplantation NCT01597102 | Johannes Gutenberg University Mainz | — |
| Completed | Liver Function After Intravenous Methylprednisolone Administration NCT03667157 | Medical University of Warsaw | Phase 4 |
| Completed | A Comparative Analysis of Preoperative Liver Volumetry in Living Donor Liver Transplantation NCT06865612 | Chungnam National University Hospital | — |
| Active Not Recruiting | Biliary Complication Rates in Living Donor Liver Transplantation: a Retrospective Comparative Study of Stent V NCT06767553 | Chungnam National University Hospital | — |
| Completed | SPME For Metabolomics And Concomitant Measurements Of Rocuronium Bromide Levels In Liver Transplantation NCT01404793 | University Health Network, Toronto | — |
| Completed | Autoregulation Assessment During Liver Transplantation NCT01425385 | Johns Hopkins University | — |
| Completed | Interstage Assessment of Remnant Liver Function in ALPPS NCT02846441 | Hospital Italiano de Buenos Aires | — |
| Active Not Recruiting | Veliparib, Paclitaxel, and Carboplatin in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be NCT01366144 | National Cancer Institute (NCI) | Phase 1 |
| Unknown | A Study Evaluating the Efficacy of Glucocorticoids in Patients With Pre-ACLF-HBV NCT01344174 | Third Military Medical University | N/A |
| Completed | Effects on Plasma Exchange on Functional Capacity of Serum Albumin, Circulatory Dysfunction, Renal and Cerebra NCT01201720 | Instituto Grifols, S.A. | N/A |
| Unknown | Allogeneic Bone Marrow Mesenchymal Stem Cells Transplantation in Patients With Liver Failure Caused by Hepatit NCT01322906 | Sun Yat-sen University | Phase 2 |
| Completed | Assessment of Renal Function in Cirrhotic Patients NCT01895114 | Baylor Research Institute | — |
| Unknown | Allogenic Bone Marrow Stem Cell Transplantation in Liver Failure NCT01221454 | Sun Yat-sen University | Phase 2 |
| Completed | Donor Simvastatin Treatment in Organ Transplantation NCT01160978 | Helsinki University Central Hospital | Phase 2 / Phase 3 |
| Completed | Raltegravir in Patients With End Stage Liver Disease and in Transplant Recipients NCT01022476 | ANRS, Emerging Infectious Diseases | Phase 1 / Phase 2 |
| Completed | Parenteral Lipid Emulsions and the Liver Function NCT03044639 | Stanley Dudrick's Memorial Hospital | Phase 4 |
| Completed | Somatic Disease Among Alcohol Abusers in an Out-day Patients' Clinic NCT01081197 | Helse Nord-Trøndelag HF | — |
| Unknown | Everolimus in de Novo Liver Transplantation: a Multicentre Randomized Study NCT01423708 | Azienda Ospedaliera di Padova | Phase 2 |
| Terminated | Intravenous Milk Thistle (Silibinin-Legalon) for Hepatic Failure Induced by Amatoxin/Amanita Mushroom Poisonin NCT00915681 | Mylan Specialty, LP | Phase 2 |
| Withdrawn | Acetaminophen in Combination With N-Acetylcysteine (NAC) Versus Placebo in Treating Fever NCT01137591 | Columbia University | N/A |
| Unknown | Safety and Efficacy of Human Mesenchymal Stem Cells for Treatment of Liver Failure NCT01218464 | Beijing 302 Hospital | Phase 1 / Phase 2 |
| Unknown | Understanding Patient's Knowledge and Use of Acetaminophen NCT00823758 | M.D. Anderson Cancer Center | — |
| Completed | Pharmacokinetics of LCP-Tacro™ Once Daily and Prograf® Twice A Day in Adult De Novo Liver Transplant Patients NCT00772148 | Veloxis Pharmaceuticals | Phase 2 |
| Unknown | Oxidative Stress and Microcirculation in Patient With Hepatic Failure Undergoing Liver Support Treatment NCT00772252 | National Taiwan University Hospital | — |
| Unknown | Citrate Anticoagulation During MARS Treatment NCT00695617 | Universitaire Ziekenhuizen KU Leuven | Phase 2 / Phase 3 |
| Unknown | Preoperative Glucose Infusion: a Novel Strategy to Improve Liver Function After Liver Resection NCT00623662 | McGill University Health Centre/Research Institute of the McGill University Health Centre | N/A |
| Completed | Pharmacokinetics of LCP-Tacro in Stable Liver Transplant Patients NCT00608244 | Veloxis Pharmaceuticals | Phase 2 |
| Completed | Microcirculation and Oxidative Stress in Critical Ill Patients in Surgical Intensive Care Unit NCT00808691 | National Taiwan University Hospital | — |
| Completed | Myocardial Perfusion Imaging in Liver Transplantation Candidates NCT03864497 | University Hospital Birmingham NHS Foundation Trust | — |
| Completed | The Efficacy and Safety of Entecavir Treatment of Patients With Acute on Chronic Hepatitis B Liver Failure NCT01254994 | Sun Yat-sen University | Phase 2 |
| Completed | Safety and Tolerance on Lipids of Parenteral and Enteral Nutrition in Critically Ill Patients With Liver Failu NCT00522730 | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | Phase 4 |
| Completed | Study to Evaluate if the Drug Vasopressin Protects the Kidneys for Patients Undergoing Liver Transplant NCT00886262 | Medical University of South Carolina | N/A |
| Completed | Use of N-Acetylcysteine During Liver Procurement NCT01394497 | Azienda Ospedaliera di Padova | Phase 2 |
| Completed | Improvement of Liver Function in Liver Cirrhosis Patients After Autologous Mesenchymal Stem Cell Injection:a P NCT00420134 | Shahid Beheshti University of Medical Sciences | Phase 1 / Phase 2 |
| Completed | Therapeutic Effects of Liver Failure Patients Caused by Chronic Hepatitis B After Autologous MSCs Transplantat NCT00956891 | Sun Yat-sen University | — |
| Completed | Clinical Trial of Pentoxifylline in Patient With Cirrhosis NCT00162552 | Assistance Publique - Hôpitaux de Paris | Phase 3 |
| Completed | Recompensation of Exacerbated Liver Insufficiency With Hyperbilirubinemia and/or Encephalopathy and/or Renal F NCT00614146 | Vantive Health LLC | N/A |
| Completed | Elimination of Albumin-Bound Substances by MARS and Prometheus NCT00407004 | Medical University of Graz | N/A |
| Completed | Multidisciplinary Inpatient Palliative Care Intervention NCT00325611 | Kaiser Permanente | N/A |
| Completed | Efficacy of Albumin Dialysis to Treat Patients With Hepatic Encephalopathy Using The Molecular Adsorbent Recir NCT00287235 | Vantive Health LLC | N/A |
| No Longer Available | Use of the ELAD® in Patients With Liver Failure to Provide Expanded Access With Cost Recovery NCT00832273 | Vital Therapies, Inc. | — |