Trials / Completed
CompletedNCT03864497
Myocardial Perfusion Imaging in Liver Transplantation Candidates
Exercise Capacity and Single Photon Emission Computed Tomography in Liver Transplantation Candidates Study
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 403 (actual)
- Sponsor
- University Hospital Birmingham NHS Foundation Trust · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
The optimal screening strategy for assessment of coronary artery disease in patients with end-stage liver disease (ESLD) is unclear. Although consensus based guidelines support noninvasive stress testing prior to orthotopic liver transplantation (OLT), no prospective studies are available to inform the clinician on perioperative risk stratification. This observational cohort study was designed to determine the prognostic utility of single photon emission computed tomography (SPECT) imaging in OLT candidates.
Detailed description
Controversy over whether SPECT imaging offers clinical utility in ESLD has been fuelled by conflicting reports on its accuracy to diagnose CAD in this setting. Moreover, there are no studies examining whether SPECT imaging provides any incremental prognostic value beyond functional testing in this high-risk cohort. We sought to determine the relative importance of CV risk factors, functional capacity and SPECT perfusion results as independent predictors of cardiovascular mortality in OLT candidates.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | Myocardial perfusion imaging |
Timeline
- Start date
- 2007-09-01
- Primary completion
- 2019-06-01
- Completion
- 2019-06-01
- First posted
- 2019-03-06
- Last updated
- 2019-06-19
Source: ClinicalTrials.gov record NCT03864497. Inclusion in this directory is not an endorsement.