NCT06224023

Predictive Values of Presepsin Levels in ASciteS in Patients With Chronic Liver Failure

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 30 (estimated)
• Sponsor: Carol Davila University of Medicine and Pharmacy · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The investigators aim to study the predictive value of presepsin in ascites in newly admitted patients with chronic liver failure.

Detailed description

Presepsin is a plasmatic cleaved fragment of CD14. CD14 is a toll like receptor who has the role to identify certain lipopolysaccharides on the surface of bacteria (aerobes and anaerobes), thus promoting an inflammatory response. A study of 153 patients with liver cirrhosis published by a team of investigators from Iasi, Romania, has proven an useful role of plasma presepsin in early diagnosis of infections in patients in acute on chronic liver failure. In addition, plasma presepsin has been proposed as an independent predictor of mortality in patients with decompensated liver cirrhosis, without concomitant bacterial infections. Question to be answered by this study The investigators aim to evaluate the predictive role of ascites presepsin in patients with chronic liver failure. Hypothesis Presepsin levels in ascites may have a prognostic role in patients with ascites and chronic liver failure.

Conditions

• Ascites Hepatic
• Liver Failure
• Cirrhosis, Liver

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Determination of presepsin levels in ascites	A diagnostic paracentesis will be performed and presepsin level will be determined in ascites.

Timeline

• Start date: 2024-08-01
• Primary completion: 2024-12-31
• Completion: 2024-12-31
• First posted: 2024-01-25
• Last updated: 2024-08-21

Locations

1 site across 1 country: Romania