| Enrolling By Invitation | Implant-Related Infections in Patients With Skeletal Sarcomas NCT07264296 | Vastra Gotaland Region | — |
| Withdrawn | Genicular Artery Embolization (GAE) for Osteoarthritic Knee Pain NCT04472091 | Andrew Picel | N/A |
| Completed | Two-level ESPB in Total Knee Arthroplasty NCT06470542 | Poznan University of Medical Sciences | Phase 4 |
| Not Yet Recruiting | Effect of Bupivacaine Liposomes or Bupivacaine for Femoral Triangle or Adductor Block on Analgesia After Total NCT06653621 | Huazhong University of Science and Technology | Phase 4 |
| Completed | Dexamethasone vs. Dexmedetomidine for ESPB in Pain Management After Knee Arthroplasty NCT06470100 | Poznan University of Medical Sciences | Phase 4 |
| Completed | Dexamethasone for iPACK Block With ACB in Total Knee Arthroplasty NCT06470204 | Poznan University of Medical Sciences | Phase 4 |
| Not Yet Recruiting | Non-Invasive Distractor During Knee Arthroscopy NCT06458816 | The Taylor Collaboration | N/A |
| Not Yet Recruiting | Comparison of Two Robotic-Assisted Total Knee Arthroplasty Systems NCT06284824 | Southeast Orthopedic Specialists | N/A |
| Unknown | ESPB vs iPACK+ACB in Total Knee Arthroplasty NCT06302218 | Poznan University of Medical Sciences | Phase 4 |
| Completed | Erector Spinae Plane Block Vs. IPACK Block with Adductor Canal Block for Total Knee Arthroplasty NCT06233630 | Poznan University of Medical Sciences | Phase 4 |
| Enrolling By Invitation | Persona IQ Cohort Study NCT06089291 | Zimmer Biomet | — |
| Unknown | The Roles of MRI, DYNEELAX and Stress X-ray in First-Line Diagnosis of Cruciate Ligament Injury NCT06259773 | Kaohsiung Veterans General Hospital. | — |
| Not Yet Recruiting | Follow-up Study for Participants of Jointstem Investigator Initiated Trial by Arthroscopy NCT04825730 | R-Bio | N/A |
| Completed | Methylprednisolone Taper After Total Knee Replacement NCT05859269 | Emory University | Phase 4 |
| Completed | The Effect of PPB Using 10, 20 and 30 ml of Lidocaine, Study on Volunteers NCT05464862 | Charlotte Runge | Phase 4 |
| Completed | Maximal Rate of Force Development of Ankle Muscles and Functional Ability in Patients With Knee Osteoarthritis NCT06063889 | Ahram Canadian University | — |
| Recruiting | QIST Collaborative - Arthroplasty Research Cohort (ARC) Study NCT05824845 | Northumbria Healthcare NHS Foundation Trust | — |
| Unknown | Investigator Initiated Trial to Evaluate Cartilage Regeneration by Arthroscopy After JOINTSTEM Administration NCT04821102 | R-Bio | N/A |
| Completed | Incidence of Tenderness Opposite to Adductor Canal in Patients Suffering From Osteoarthritis Knee Pain. A Coho NCT06630052 | Cairo University | — |
| Terminated | In-vivo Wear Behaviour of AS Coated Versus Uncoated Columbus® Total Knee Prosthesis NCT05509972 | Aesculap AG | — |
| Recruiting | Evaluating XPERIENCE™ Advanced Surgical Irrigation NCT05543941 | Ottawa Hospital Research Institute | N/A |
| Recruiting | Intra-Operative Adductor Canal Blocks NCT05601427 | Ottawa Hospital Research Institute | N/A |
| Completed | Mechanical Traction Force and Knee Joint Space NCT05699733 | University of Hail | N/A |
| Unknown | Evaluation and Characterisation of Microplastics and Nanoplastics in Joint Synovial Liquid NCT05678049 | Iuliu Hatieganu University of Medicine and Pharmacy | — |
| Completed | ESPB vs FICB for Pain Management Following Total Hip Prosthesis Surgery NCT05621161 | Mursel Ekinci | N/A |
| Completed | Para-sartorial Compartment Block in Knee Surgery NCT05566561 | Medipol University | N/A |
| Completed | Assessment of Postural Stability in Patients With Total Knee Arthroplasty NCT05420194 | Acibadem University | — |
| Completed | Evaluation of the Effect of the AI500™ SINGLE-DOSE GEL Medical Device in Patients With Reduced Knee Function NCT05886608 | Contrad Swiss SA | N/A |
| Unknown | Return to Work After Total Knee Arthroplasty in Young Patients NCT05521555 | Central Hospital, Nancy, France | — |
| Recruiting | Cannabidiol (CBD) in Pain Reduction for Knee Osteoarthritis NCT05020028 | NYU Langone Health | Phase 2 / Phase 3 |
| Completed | A Study of the Feasibility of Using the Dietary Supplement "ARTNEO" in Patients With Osteoathritis NCT05975879 | NPO Petrovax | N/A |
| Unknown | Chitosan Versus Glucosamine Phonophoresis in the Management of Knee Osteoarthritis NCT05420441 | October 6 University | N/A |
| Completed | The Effect of Telerehabilitation-Based Exercise and Training on Outcome Measures in Patients With Knee Osteoar NCT05209893 | Ege University | N/A |
| Active Not Recruiting | Dorsal Root Ganglion Stimulation for the Treatment of Arthritic Knee Pain NCT05103527 | Kenneth B Chapman | N/A |
| Completed | Lyophilized and Micronized Particulate Human Amniotic and Umbilical Cord (TTAX03) for KL Grade 3-4 Knee OA NCT05079035 | BioTissue Holdings, Inc | Phase 2 |
| Unknown | Exploratory Study of Ultrasound Signs of Native Septic Arthritis of the Knee NCT04952220 | Poitiers University Hospital | — |
| Completed | Internal Unicompartmental Arthroplasty After Tibial Valgization Osteotomy NCT06559592 | University Hospital, Brest | — |
| Active Not Recruiting | Triathlon All-Polyethylene Tibia Outcomes Study NCT04636190 | Stryker Orthopaedics | N/A |
| Completed | Variations in Osteoarthritic Knee Laxity Between Individuals and Populations NCT05018507 | The Royal Wolverhampton Hospitals NHS Trust | — |
| Completed | Robotic-assisted Total Knee Arthroplasty vs. Conventional One NCT04611815 | Medical University of Warsaw | N/A |
| Unknown | Comparison of TKAs Using Force Plate Analysis NCT04163445 | Russell Nevins, M.D. | N/A |
| Completed | ROMTECH PortableConnect Rehabilitation Device Usage Post Unilateral Total Knee Arthroplasty (TKA) NCT04497129 | ROM Technologies, INC | N/A |
| Completed | Gold Factor on Knee Joint Health and Function NCT05347602 | 4Life Research, LLC | N/A |
| Unknown | Persona MC Retained PCL vs. Persona Posterior-stabilized vs. NexGen PS NCT04164147 | Medical University of Warsaw | N/A |
| Completed | Pain Management After Adductor Canal Block for Total Knee Arthroplasty NCT06086483 | Poznan University of Medical Sciences | Phase 4 |
| Completed | Effects of Whey and Collagen on FFM, Muscle Strength and Wound Healing in Elderly Surgical Patients NCT04496856 | University of Copenhagen | N/A |
| Unknown | Comparison of Multiradius and Singleradius Total Knee Arthroplasty NCT04364971 | Bezmialem Vakif University | N/A |
| Unknown | Association Between Sagittal Patellar Offset and Anterior Knee Pain in Total Knee Arthroplasty NCT04353440 | Bezmialem Vakif University | — |
| Unknown | Rate of Torque Development and Voluntary Quadriceps Activation in Patients With Knee Osteoarthritis: A Quantit NCT04234282 | Jennifer Moreno Clinic | N/A |
| Completed | Pulsed Radiofrequency and Osteoarthritic Chronic Knee Pain NCT04454710 | University of Rome Tor Vergata | N/A |
| Terminated | Cognition, Pain and Wellbeing NCT04620525 | University of Nottingham | — |
| Completed | The Efficacy of Collaborative Patient Education on Total Knee Arthroplasty NCT05346822 | Kaohsiung Medical University Chung-Ho Memorial Hospital | N/A |
| Active Not Recruiting | Blood-Flow Restriction Exercise Following a Knee Replacement NCT04018638 | Michigan Technological University | N/A |
| Completed | Evaluation of NMES for Reducing Pain and Improving Functional Outcomes in Knee OA Patients NCT03980964 | CyMedica Orthopedics, Inc | N/A |
| Completed | Mechanism of IL-10 Pathway-mediated Regulatory B Cell Dysfunction in Osteoarthritis NCT06227195 | Shufeng Li | — |
| Unknown | Evaluation of Multidisciplinary Recovery After Surgery Program in Orthopedics and Traumatology NCT03822247 | Klinički Bolnički Centar Zagreb | N/A |
| Completed | An Analysis of the Outcomes From Protocolized Perioperative Care for Patients Receiving Total Hip or Knee Arth NCT03071250 | University of Arkansas | — |
| Unknown | Efficacy of Intra-articular NSAID Versus Corticosteroid in the Treatment of Shoulder and Knee Conditions: A Ra NCT03616340 | OSF Healthcare System | Phase 3 |
| Unknown | Knee Arthritis Treatment With Autologous Fragmented Adipose Tissue and PRP - Comparison of Two Treatment Metho NCT04321629 | Rehasport Clinic | Phase 2 |
| Completed | Telemedicine in Total Knee Arthroplasty Using Wearable Technology NCT03406455 | The Cleveland Clinic | — |
| Withdrawn | Comparison of Implant Positioning With Robotic Aided Surgery and Traditional Jig Positioning in Total Knee Art NCT03052790 | The University of Texas Health Science Center, Houston | N/A |
| Completed | Skin to Adductor Canal Distance in Various Positions NCT03562559 | University of British Columbia | — |
| Active Not Recruiting | Performance of MOTO Medial® Unicompartmental Knee Arthroplasty NCT03211663 | Medacta USA | — |
| Completed | Effectiveness of Reduced Frequency Physical Therapy in Total Knee Arthroplasty NCT03302832 | Campbell University, Incorporated | N/A |
| Completed | Total Fat Pad Excision Leads to Worse Isokinetic Performance in Total Knee Arthroplasty NCT04419142 | Aksaray University Training and Research Hospital | N/A |
| Completed | AP-003-C Study to Confirm the Efficacy of Ampion™ in Adults With Pain Due to Severe Osteoarthritis of the Knee NCT03182686 | Ampio Pharmaceuticals. Inc. | Phase 3 |
| Completed | Metabolic Syndrome and Degenerative Meniscus Lesions Related Knee Function NCT04921202 | The First People's Hospital of Jingzhou | — |
| Completed | Kinematic Parameters to Predict Knee Diseases. NCT03130400 | Guangzhou General Hospital of Guangzhou Military Command | — |
| Completed | Isokinetic Performance After Cruciate-substituting Ultra-congruent and Posterior Stabilized Total Knee Arthrop NCT04419311 | Aksaray University Training and Research Hospital | N/A |
| Terminated | Effectiveness of Titanium Niobium Nitride Coating in Total Knee Arthroplasty NCT02831595 | Permedica spa | — |
| Completed | Treatment of Knee Osteoarthrosis Using the Electromagnetic Fields NCT03421249 | Faculdade de Ciências Médicas da Santa Casa de São Paulo | N/A |
| Completed | Preoperative Pain Threshold and Rapid Recover Programs NCT02740738 | Duke University | N/A |
| Unknown | NEUROIMPA - Intraarticular Application of Opioids in Chronic Arthritis of the Knee Joint NCT02967302 | Hildrun Haibel | Phase 2 / Phase 3 |
| Completed | Spinal Anesthesia Versus Combined Sciatic-femoral Nerve Block for Outpatient Knee Arthroscopy NCT02384915 | ASST Gaetano Pini-CTO | Phase 4 |
| Completed | TXA vs. Amicar in Total Knee and Hip Arthroplasty NCT02030821 | Duke University | Phase 4 |
| Completed | Preventive Effect of Proprioceptive Stimulation on Muscle Atrophy NCT01641627 | University Hospital, Lille | Phase 1 / Phase 2 |
| Completed | The Assessment of Patient Specific Instrumentation for Unicompartmental Knee Replacement NCT02748096 | Oxford University Hospitals NHS Trust | N/A |
| Completed | Preoperative Alignment of Total Knee Replacement NCT01242085 | VA Palo Alto Health Care System | Phase 3 |
| Completed | Perioperative Analgesia for Knee Arthroplasty (PAKA) NCT01560767 | University of Warwick | Phase 4 |
| Completed | Knee Arthroplasty Performed With Conventional and Customized Instrumentation NCT01124305 | Anderson Orthopaedic Research Institute | Phase 4 |
| Completed | Oxford Unicompartmental Knee Arthroplasty With and Without Navigational Unit NCT00862316 | Zimmer Biomet | N/A |
| Terminated | New Tool of Subjective and Objective Functional Evaluation and the Quality of Life After Arthroplastic Surgery NCT00894218 | Assistance Publique Hopitaux De Marseille | N/A |
| Completed | Comparison Between Fixed- Versus Mobile-bearing TKA NCT00435357 | Hospices Civils de Lyon | N/A |
| Withdrawn | Total Knee Replacement Using Simplex® or Cobalt™ Bone Cement NCT00589485 | Zimmer Biomet | — |
| Terminated | I-beam and Cruciate Tibial Components Used in Total Knee Replacement NCT00588783 | Biomet Orthopedics, LLC | — |
| Terminated | Total Knee Replacement With Duracon® and Vanguard™ Prostheses NCT00588887 | Biomet Orthopedics, LLC | — |
| Completed | Application of Computer-assisted Navigation in Total Knee Arthroplasty: A Randomized Pair-matched Double-blind NCT00982956 | Chinese PLA General Hospital | — |