Trials / Completed
CompletedNCT06227195
Mechanism of IL-10 Pathway-mediated Regulatory B Cell Dysfunction in Osteoarthritis
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 40 (actual)
- Sponsor
- Shufeng Li · Academic / Other
- Sex
- All
- Age
- 40 Years – 80 Years
- Healthy volunteers
- Not accepted
Summary
Our previous work has shown that Treg function is impaired in OA patients, but the cause of Treg deficiency has not been investigated. Since Breg has been shown to promote Treg differentiation and tissue repair, it is highly likely that the absence of the immunomodulatory effect of Breg in OA patients leads to impaired Treg differentiation. Based on the above data, we hypothesized that Breg plays a protective role in the course of OA by regulating T cell composition and promoting Treg differentiation through the secretion of anti-inflammatory factor IL-10
Conditions
Timeline
- Start date
- 2019-01-01
- Primary completion
- 2021-12-31
- Completion
- 2021-12-31
- First posted
- 2024-01-26
- Last updated
- 2024-01-26
Locations
1 site across 1 country: China
Source: ClinicalTrials.gov record NCT06227195. Inclusion in this directory is not an endorsement.