| Not Yet Recruiting | An Exploratory Study of the Efficacy and Safety of Esketamine and Dexmedetomidine in Non-Intubated ICU Patient NCT07377981 | The First Affiliated Hospital with Nanjing Medical University | Phase 4 |
| Not Yet Recruiting | Esketamine Versus Crisis Response Planning Versus Optimized Treatment as Usual for Suicide Prevention: A Pragm NCT07120477 | University of Sao Paulo | Phase 4 |
| Recruiting | Induction Agent Choice With Early Mortality and Prognostic Outcomes in Critically Ill Patients NCT07222007 | Zeliha Alicikus | — |
| Not Yet Recruiting | Intraoperative Ketamine for Chronic Postoperative Pain After Open-Heart Surgery NCT07490457 | Bursa City Hospital | N/A |
| Not Yet Recruiting | Role of Opioid Free Anaesthesia in Elderly Patients Undergoing Elective Coronary Artery Bypass Graft Surgeries NCT07360327 | Ain Shams University | N/A |
| Recruiting | Ketamine-lidocaine Versus Ketamine-fentanyl for Induction of Anesthesia in Patients With Left Ventricular Syst NCT07248202 | Cairo University | N/A |
| Recruiting | Anesthesia Techniques, Neuroprotection and Surgical Field in FESS Under Controlled Hypotension NCT07181564 | University General Hospital of Patras | N/A |
| Completed | Ketamine as an Adjuvant in External Oblique Intercostal Plane Block for Post Thoracotomy Pain NCT07138781 | Tanta University | N/A |
| Completed | Ketamine Administration for Postoperative Pain Management in Patients Undergoing Knee Arthroplasty NCT07059429 | State Budgetary Healthcare Institution, National Medical Surgical Center N.A. N.I. Pirogov, Ministry of Health of Russia | N/A |
| Completed | Erector Spinae Block Vs Ketamine-based Multimodal Analgesia Protocol in Lumber Decompressive Surgery NCT07001605 | Kasr El Aini Hospital | N/A |
| Recruiting | Intraoperative Combination of Ketamine and Magnesium Sulfate Infusions on Postoperative Analgesia in Open Rhin NCT06966518 | Ain Shams University | N/A |
| Recruiting | Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Trea NCT06511908 | National Institute of Mental Health (NIMH) | Phase 2 |
| Recruiting | Nebulized Ketamine for the Treatment of Major Depressive Disorder in an Inpatient Setting NCT06752759 | Theresa Jacob, PhD, MPH | Phase 3 |
| Recruiting | Natural History of Depression, Bipolar Disorder and Suicide Risk NCT06462196 | National Institute of Mental Health (NIMH) | — |
| Completed | Postoperative Opioid Consumption in Gastric Sleeve Surgery NCT07135154 | Balikesir University | — |
| Completed | General Anesthesia Versus Sedation By Dexmedetomidine and Ketamine With Local Infiltration for Percutaneous Tr NCT06431178 | Tanta University | N/A |
| Completed | Characterization of the Temporal Profile of the Anti-nociceptive Effect of Ketamine Bolus Measured With ANI NCT06344858 | Pontificia Universidad Catolica de Chile | — |
| Completed | Propofol-ketamine or Propofol-fentanyl for Procedural Sedation in the Short-term Gynecological Case NCT06412861 | Ondokuz Mayıs University | N/A |
| Completed | Dexmedetomidine and Ketamine as an Adjuvant in External Oblique Intercostal Plane Block for Post Thoracotomy P NCT06331182 | Tanta University | N/A |
| Active Not Recruiting | Effect of Low-dose Esketamine on Maternal Depression at 3 Years After Childbirth NCT05698394 | Peking University First Hospital | Phase 4 |
| Completed | Adding Ketamine to Levobupivacaine in Paravertebral Block in Thoracotomy NCT06011746 | Tanta University | Phase 4 |
| Completed | Hemodynamic Effects of Bolus of Ketamine Versus Fentanyl in Patients With Septic Shock NCT05957302 | Cairo University | N/A |
| Unknown | Dexmedetomidine, Ketamine and Magnesium Sulphate in Caudal Block for Hypospadias Repair NCT05837000 | Kafrelsheikh University | Phase 4 |
| Completed | Effect of Ketamine Infusion on BIS Values NCT05799729 | University of Padova | — |
| Completed | Oral Aspirin + Ketamine as Adjunct to Oral Antidepressant Therapy for Depression NCT05615948 | Maimonides Medical Center | Phase 4 |
| Unknown | Opioid Sparing Anesthesia in Cervical Spine Surgery NCT05717361 | Evangelismos Hospital | N/A |
| Completed | Ketamine Versus Propofol as ICU Sedation NCT06243822 | Menoufia University | Phase 4 |
| Recruiting | Safety and Efficacy of Esketamine Combined With Dexmedetomidine for Sedation of Mechanically Ventilated Patien NCT05466708 | The First Affiliated Hospital with Nanjing Medical University | Phase 4 |
| Unknown | Opioid Sparing Anesthesia in Lumbar Spine Surgery NCT05594407 | Aretaieion University Hospital | N/A |
| Completed | Effects of Subanesthetic Dose of Ketamine Given on Postoperative Mood in Patients Undergoing Fractional Curett NCT05752110 | Istanbul Training and Research Hospital | Phase 4 |
| Completed | Effect of Ketamine on BIS Values NCT05288764 | University of Padova | — |
| Unknown | Opioid-free Anesthesia in Thyroidectomies NCT05243940 | Aretaieion University Hospital | N/A |
| Unknown | Machine-learning Algorithm to Differentiate Intraoperative Ketamine Dosing Based on Electroencephalographic De NCT05256264 | Taipei Veterans General Hospital, Taiwan | — |
| Unknown | The Application of Ketamine for Sedation in Patients With Cardiac Arrest - - KetCat (KETamine in Cardiac Arres NCT04360070 | Fraser Health | N/A |
| Completed | Esketamine Sedation and Fentanyl Sedation in Pediatric Dental Patients NCT04597320 | Peking University | Phase 4 |
| Unknown | Opioid-free Anesthesia in Laparoscopic Cholecystectomies NCT05089526 | Aretaieion University Hospital | N/A |
| Unknown | Effect of Multimodal Opioid-free Anesthesia on Return of Bowel Function in Laparoscopic Colorectal Surgery NCT04144933 | University of Saskatchewan | Phase 3 |
| Unknown | Morphine Versus Ketamine as Adjuvants in Paravertebral Blocks NCT04852484 | Aretaieion University Hospital | N/A |
| Completed | The Impact of Perioperative Ketamine Infusion on Surgical Recovery NCT04625283 | Vanderbilt University Medical Center | Phase 4 |
| Unknown | Opioid-free Anesthesia With a Mixture of Dexmedetomidine-lidocaine-ketamine NCT04858711 | Aretaieion University Hospital | N/A |
| Unknown | Lidocaine and Magnesium and Ketamine in Gynecological Surgery NCT04622904 | Aretaieion University Hospital | N/A |
| Completed | Low-dose S-ketamine in Women With Prenatal Depression NCT04414943 | Peking University First Hospital | N/A |
| Completed | Low-dose S-Ketamine and Postpartum Depression in Parturients With Prenatal Depression NCT03927378 | Peking University First Hospital | N/A |
| Completed | The Pharmacokinetics of Ketamine in the Breast Milk of Lactating Women NCT04285684 | The Ketamine Research Foundation | EARLY_Phase 1 |
| Terminated | Intranasal Ketamine for Pain Control in Patients with Sickle Cell Disease and Vaso-occlusive Episode (VOE) in NCT04150757 | Abigail Nixon | Phase 3 |
| Completed | A Naturalistic Study of Ketamine for Treatment Resistant Mood Disorders NCT04226963 | Medical University of Gdansk | — |
| Completed | EEG Characteristics in ECT NCT04022226 | University of New Mexico | EARLY_Phase 1 |
| Completed | THC and Ketamine Effects in Humans: Relation to Neural Oscillations and Psychosis NCT04199468 | Yale University | Phase 1 |
| Terminated | Intranasal Versus Intravenous Ketamine for Procedural Sedation in Children With Non-operative Fractures NCT03781817 | University of Alabama at Birmingham | Phase 4 |
| Completed | Use of Ketamine for Conscious Sedation in Flexible Bronchoscopy NCT06181188 | Brooke Army Medical Center | Phase 4 |
| Completed | Comparison Between Low-dose Ketamine Infusion and Intravenous Morphine NCT04281628 | Cairo University | Phase 4 |
| Unknown | Ketamine Co-induction for Patients With Major Depressive Disorder NCT03666494 | University of Saskatchewan | Phase 4 |
| Unknown | Continuous IntraVenous Infusion of Ketamine in Terminally Ill Cancer Patients NCT03362073 | Pusan National University Yangsan Hospital | Phase 2 |
| Completed | Rapid Agitation Control With Ketamine in the Emergency Department NCT03375671 | David Barbic | Phase 2 |
| Completed | Perioperative Ketamine for Pain With Gastric Bypass NCT03448068 | Mayo Clinic | Phase 2 |
| Completed | Effect of Ketamine in Depressive Symptoms of Elderly Patients With Visual Impairment. NCT03473431 | Instituto Mexicano del Seguro Social | N/A |
| Completed | PCA Ketamine-Morphine VS PCA Morphine as Post-Operative Analgesia in Colorectal Surgery NCT06021717 | Universiti Kebangsaan Malaysia Medical Centre | Phase 4 |
| Completed | PCA Ketamine-Morphine VS PCA Morphine as Post-Operative Analgesia in Colorectal Surgery. NCT06010056 | National University of Malaysia | Phase 4 |
| Completed | Comparison of Efficacy of Anesthesia Administered by Endoscopist or Anesthesiologist on Colonoscopy NCT03607110 | Selda KAYAALTI | — |
| Completed | Low-dose Ketamine and Postpartum Depression in Parturients With Prenatal Depression NCT03336541 | Peking University First Hospital | Phase 4 |
| Completed | Efficacy of Opioid-free Anesthesia in Reducing Postoperative Respiratory Depression in Children Undergoing Ton NCT02987985 | University of Saskatchewan | Phase 3 |
| Recruiting | ECT with Ketamine Anesthesia Vs High Intensity Ketamine with ECT Rescue for Treatment-Resistant Depression NCT03272698 | University of Saskatchewan | Phase 4 |
| Completed | ELEKT-D: Electroconvulsive Therapy (ECT) vs. Ketamine in Patients With Treatment Resistant Depression (TRD) NCT03113968 | Bo Hu | Phase 2 / Phase 3 |
| Unknown | Positron Emission Tomography Assessment of Ketamine Binding of the Serotonin Transporter NCT02717052 | Medical University of Vienna | Phase 2 |
| Terminated | Effect of Ketamine on Fatigue Following Cancer Therapy NCT02317341 | National Institute of Nursing Research (NINR) | EARLY_Phase 1 |
| Completed | Use of S+Ketamine During Target-Controlled Intravenous Anaesthesia After Abdominal Hysterectomy NCT03231683 | KK Women's and Children's Hospital | Phase 2 |
| Completed | KETOR: Effects of Peri Operative Administration of Ketamine on Long Term Post Thoracotomy Pain NCT00224588 | Assistance Publique - Hôpitaux de Paris | Phase 3 |