NCT05837000

Dexmedetomidine, Ketamine and Magnesium Sulphate in Caudal Block for Hypospadias Repair

Role of Adding Dexmedetomidine, Ketamine and Magnesium Sulphate to Caudal Block as Preemptive Analgesia in Hypospadias Repair in Pediatrics: a Randomized Double-blinded Trial

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 75 (estimated)
• Sponsor: Kafrelsheikh University · Academic / Other
• Sex: Male
• Age: 1 Year – 7 Years
• Healthy volunteers: Not accepted

Summary

Caudal epidural block is a rapid, reliable, and safe technique that can be used with general anesthesia for intraoperative and postoperative analgesia in pediatric patients Ketamine is a selective antagonist of N-methyl-D-aspartate (NMDA) receptor, an ionotropic glutamate receptor.

Conditions

• Preemptive Analgesia
• Dexmedetomidine
• Ketamine
• Magnesium Sulphate
• Hypospadias
• Pediatrics

Interventions

Type	Name	Description
DRUG	Dexmedetomidine	Patient will receive 0.5 ml/kg bupivacaine 0.25% + 1μg/kg dexmedetomidine caudally
DRUG	Ketamine	Patient will receive 0.5ml/kg bupivacaine 0.25% + 0.5mg/kg ketamine caudally
DRUG	Magnesium sulphate	Patient will receive 0.5ml/kg bupivacaine 0.25% + 1ml volume containing 50mg of magnesium caudally.

Timeline

• Start date: 2023-05-15
• Primary completion: 2024-10-25
• Completion: 2024-10-25
• First posted: 2023-05-01
• Last updated: 2023-06-13

Locations

1 site across 1 country: Egypt