NCT03666494

Ketamine Co-induction for Patients With Major Depressive Disorder

Ketamine Co-induction for Patients With Major Depressive Disorder; a Randomized Clinical Trial

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 50 (estimated)
• Sponsor: University of Saskatchewan · Academic / Other
• Sex: Female
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Ketamine hydrochloride, an anesthetic medication, has been demonstrated to acutely and rapidly improve depressive symptoms but not yet been adequately studied for this effect when used as part of a general anesthetic for surgery. This proposed single-centre, double-blinded, randomized clinical trial of adult patients with depression presenting for gynecologic surgery would compare severity of depressive symptoms between patients receiving and not receiving ketamine as part of their general anesthetic.

Conditions

• Ketamine
• Depression
• Anesthesia

Interventions

Type	Name	Description
DRUG	Ketamine Hydrochloride	As part of anesthetic induction, the addition of ketamine hydrochloride 0.5mg/kg.
DRUG	Propofol	As part of the patient's anesthetic induction, they will receive propofol.
DRUG	Fentanyl	As part of the patient's anesthetic induction, they will receive fentanyl.

Timeline

• Start date: 2018-12-01
• Primary completion: 2019-12-01
• Completion: 2019-12-01
• First posted: 2018-09-11
• Last updated: 2018-09-13

Regulatory

• FDA-regulated drug study