NCT04144933

Effect of Multimodal Opioid-free Anesthesia on Return of Bowel Function in Laparoscopic Colorectal Surgery

A Randomized Control Trial Evaluating the Utility of Multimodal Opioid-free Anesthesia on Return of Bowel Function in Laparoscopic Colorectal Surgery

• Status: Unknown
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: University of Saskatchewan · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The objective of this study is to determine if an opioid-free general anesthetic (OFA) technique utilizing lidocaine, ketamine, dexmedetomidine and magnesium reduce postoperative opioid consumption and speed return of bowel function in patients undergoing elective, laparoscopic, colorectal surgery compared to traditional opioid-containing general anesthetic techniques. It is hypothesized that this intraoperative OFA regimen will reduce postoperative opioid consumption, and expedite return of bowel function in this population.

Detailed description

The objective of this trial is to determine whether an opioid-free general anesthetic can help reduce postoperative opioid consumption and speed return of bowel function in patients undergoing elective, laparoscopic, colorectal surgery when compared with traditional opioid-containing techniques.

Conditions

• Anesthesia
• General Anesthesia
• Analgesics, Opioid
• Opioid Free Anesthesia
• Postoperative Ileus
• Colorectal Surgery
• Laparoscopic Surgery
• Analgesia
• Dexmedetomidine
• Lidocaine
• Ketamine

Interventions

Type	Name	Description
DRUG	Acetaminophen, Gabapentin	975 mg, 300 mg
DRUG	Acetaminophen, Gabapentin	975 mg, 300 mg
DRUG	Lidocaine 1% Injectable Solution, Dexmedetomidine, Ketamine	1.5 mg/kg, 0.5 mcg/kg, 0.5 mg/kg
DRUG	Dexamethasone, Ondansetron	6 mg, 4 mg
DRUG	Sevoflurane, Lidocaine 2% Injectable Solution, Ketamine, Dexmedetomidine, Magnesium Sulfate	Dose titrated to effect, 1.5 mg/kg/hr, 0.15 mg/kg/hr, 0.3 -1 mcg/kg/hr (titrated to effect), 30 mg/kg bolus over 30 minutes
DRUG	Lidocaine 1% Injectable Solution, Sufentanil	0.5 mg/kg, 0.25-0.5 mcg/kg (titrated to effect)
DRUG	Sevoflurane, Sufentanil	Dose titrated to effect, As needed (dose at anesthesiologist's discretion)

Timeline

• Start date: 2021-05-15
• Primary completion: 2024-07-30
• Completion: 2024-08-01
• First posted: 2019-10-30
• Last updated: 2023-12-20

Locations

1 site across 1 country: Canada