NCT04022226

EEG Characteristics in ECT

A Randomized Pilot Study Examining DCEEG Characteristics in Ketamine Versus Methohexital Induction in Depressed Patients Receiving Electroconvulsive Therapy

• Status: Completed
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 11 (actual)
• Sponsor: University of New Mexico · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The investigators will be examining slow-wave characteristics in depressed patients receiving electroconvulsive therapy (ECT) using direct current electroencephalogram (dcEEG) by anesthesia induction agent.

Detailed description

This is a pilot project using dcEEG to look at infra-slow waves in depressed patients receiving ECT randomized to ketamine or methohexital where ketamine suppresses infra-slow waves. The rationale for this project is to identify biomarkers of treatment adequacy in ECT, which could lead to decreased morbidity and mortality with the procedure and lessen the burden of depression in our patient population.

Conditions

• Electroconvulsive Therapy
• Direct Current Electroencephalogram
• Ketamine
• Spreadind Depression

Interventions

Type	Name	Description
DRUG	Ketamine	Induction agent that suppresses infra-slow waves
DRUG	Methohexital	Induction agent that does not suppress infra-slow waves

Timeline

• Start date: 2019-10-01
• Primary completion: 2020-10-01
• Completion: 2020-10-01
• First posted: 2019-07-17
• Last updated: 2024-10-26
• Results posted: 2024-10-26

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study