| Not Yet Recruiting | Cell Free Preimplantation Genetic Testing NCT04628507 | Genomic Prediction Inc. | — |
| Recruiting | The Effect of Supplementation With Fish Oil (EPAX EVOLVE 05) on Sperm Quality NCT06950203 | Epax Norway AS | N/A |
| Active Not Recruiting | NT-NOA - Novel Treatment of Some Men With Non-Obstructive Azoospermia NCT06706414 | Martin Blomberg Jensen | Phase 1 / Phase 2 |
| Enrolling By Invitation | Embryo Assessment Utilizing Timelapse Imaging in Conjunction With Preimplantation Genetic Testing for Aneuploi NCT06419127 | Gattaca Genomics | — |
| Active Not Recruiting | Autologous Transplantation of Human Cryopreserved Testis Tissue NCT07364409 | Herlev and Gentofte Hospital | N/A |
| Active Not Recruiting | Scanning the Meiotic Spindle in Assisted Reproductive Techniques to Assess Oocyte Quality NCT06539585 | Charles University, Czech Republic | N/A |
| Recruiting | Measuring Free Radicals in Human Sperm Cells Related to Microbiota and Lifestyle Factors NCT05514223 | University Medical Center Groningen | — |
| Not Yet Recruiting | Level of DNA-fragmentation Before and After Antioxidant-based Therapies in Male Infertility NCT06050031 | Janna Pape | — |
| Recruiting | Spermatogonial Differentiation Via Testicular Organoid NCT06841861 | CellARTs Inc. | Phase 1 / Phase 2 |
| Completed | The Influence of Fit of Underpants Worn on Semen Quality NCT06335706 | Chulalongkorn University | — |
| Unknown | Knowledge and Attitude Towards Fertility Among Emirati Infertile Patients NCT06250231 | ART Fertility Clinics LLC | — |
| Withdrawn | The Effects of Natesto For Treatment Of Hypogonadism NCT04717362 | Baylor College of Medicine | EARLY_Phase 1 |
| Completed | NAPO - Novel Approach for Oligospermia NCT06300229 | Martin Blomberg Jensen | Phase 1 / Phase 2 |
| Completed | Aromatherapy in Providing a Semen Sample NCT06241495 | Menekşe Nazlı AKER | N/A |
| Recruiting | Improvement of Reproductive Function in Men With Spinal Cord Injury (SCI) NCT05903859 | University of Miami | Phase 3 |
| Recruiting | Aftificial Inteligence in Assisted Reproductive Techniques to Assess Oocyte Quality and Embryo Ploidy NCT06539104 | Charles University, Czech Republic | — |
| Recruiting | Spermatogonial Stem Cell (SSC) Transplant and Testicular Tissue Grafting NCT04452305 | University of Pittsburgh | N/A |
| Recruiting | Power Prenatal Supplements for Sperm Quality NCT05410782 | The Bird and Be Co Inc | N/A |
| Recruiting | Prospective Study on Power Prenatal Vitamins for Males on YO Score At-home Sperm Test Results NCT05951075 | The Bird and Be Co Inc | N/A |
| Unknown | G-IVF and Sperm Parameters NCT05597631 | Vitrolife | N/A |
| Recruiting | Study of the ZyMōt Sperm Selection Method and Its Effect on Embryo Ploidy. NCT06384794 | Instituto Valenciano de Infertilidad, IVI VALENCIA | N/A |
| Completed | The Paternal Clock: Uncovering the Consequences of Advanced Paternal Age on Sperm DNA Fragmentation NCT05894356 | Clinique Ovo | — |
| Completed | Testicular Sperm Aspiration (TESA) vs. Microfluidic Sperm Separation (MSS) NCT05866484 | Clinique Ovo | — |
| Unknown | Single and Double DNA Strand Breaks in Males With Unexplained Infertility Attending Fertility Treatment NCT05846256 | Peter Humaidan | — |
| Withdrawn | Assessing the Effect of Abstinence Period on Semen Parameters NCT05701163 | Weill Medical College of Cornell University | N/A |
| Recruiting | The Association of Gut Microbiota and Spermatogenic Dysfunction NCT05628987 | Zhujiang Hospital | — |
| Completed | Detection and Prevalence of Human Papillomavirus (HPV) in Seminal Plasma and/or on Sperm in Men Undergoing Tre NCT06161727 | Vastra Gotaland Region | — |
| Unknown | Using of Testes Shocker in Improving the Spermatogenesis and Sperms Activity NCT05506722 | University of Baghdad | N/A |
| Completed | Clomiphene Citrate in Infertile Men With Idiopathic Oligoasthenozoospermia NCT06564961 | Shakeela Ishrat | Phase 3 |
| Completed | Machine Learning Based-Personalized Prediction of Sperm Retrieval Success Rate NCT06358794 | Peking University Third Hospital | — |
| Unknown | Expanding Fertility Care to Poor and Low Resourced Settings Study NCT05205733 | University of California, San Francisco | N/A |
| Completed | Sperm Selection Using Microfluidic Technology NCT04997070 | CRG UZ Brussel | — |
| Unknown | Influence of Pb&Cd Seminal Plasma Level & ICSI NCT04286633 | Assiut University | — |
| Unknown | Effect of COVID-19 on Platelet Mitochondrial Bioenergetic, Antioxidants and Oxidative Stress in Infertile Men. NCT05421234 | Comenius University | N/A |
| Active Not Recruiting | FITMI - First In Treating Male Infertility NCT05212337 | Martin Blomberg Jensen | Phase 2 |
| Completed | Reproductive Outcome After Sperm Selection for Intracytoplasmic Sperm Injection (ICSI) Using Zona Pellucida Pr NCT05161247 | Nadezhda Women's Health Hospital | N/A |
| Completed | Impact of Co Enzyme Q10 as Adjuvant Therapy to Letrozole on Spermiogram NCT05847257 | Al-Mustansiriyah University | Phase 2 |
| Completed | Effects of Antioxidant Supplementation of Culture Media on IVF Embryos NCT05919186 | Liliana Berenice Ramírez Domínguez | N/A |
| Unknown | Abstinence Period and Semen Quality NCT04955782 | ART Fertility Clinics LLC | — |
| Terminated | Impact of the Coronavirus Disease 2019 (COVID-19) on Sperm Parameters NCT04937608 | Fertilys | — |
| Unknown | Stress in Couples Undergoing Assisted Reproduction Technology With Donor Sperm and Its Impact on Pregnancy Out NCT04924309 | Women's Hospital School Of Medicine Zhejiang University | — |
| Completed | Assessment of TetraSOD® Efficacy to Improve Semen Parameters in Men With Idiopathic Infertility NCT04864314 | Fitoplancton Marino, S.L. | N/A |
| Completed | Outcome of Using Sperm Bound to the Zona Pellucida of Immature Oocytes for Intracytoplasmic Sperm Injection (I NCT05724979 | Al-Azhar University | N/A |
| Completed | The Effect of a Multimodal Lifestyle Program on Male Fertility NCT04761250 | Peter Humaidan | N/A |
| Completed | Fertility Preservation in Male AYA With Cancer NCT04268004 | Leena Nahata | N/A |
| Withdrawn | Male Reproduction COVID Sequelae Study (MARCOS). NCT04665258 | University of Miami | — |
| Unknown | Varicocele Repair for Men Undergoing IVF/ICSI NCT04608864 | Al-Yasmeen Fertility and Gynecology Center | N/A |
| Recruiting | Experimental Round Spermatid Injection (ROSI) to Treat Infertile Couples NCT04298255 | Wake Forest University Health Sciences | N/A |
| Completed | Yeast Cells as Antioxidant-Producing Probiotics NCT02814695 | Benha University | Phase 1 |
| Completed | The Outcome of Two Protocols Used to Prepare Endometrium for Frozen Embryo Transfer NCT04507022 | Rahem Fertility Center | Phase 4 |
| Completed | Retrospective Study on the Use, Efficiency, and Safety of the At-home Mosie Kit NCT04646291 | Mosie Baby | — |
| Withdrawn | Determining the Reproductive Health of Men Post-COVID-19 Infection NCT04414904 | Imperial College London | — |
| Completed | Microbiome Influence on Seminal Quality NCT04784260 | Instituto Valenciano de Infertilidad, IVI Alicante | — |
| Unknown | SARS-CoV-2, TESTOSTERONE AND MALE FRAGILITY NCT06177002 | IRCCS San Raffaele | — |
| Unknown | Impact of A Nutritional Supplements' Combination (FERTILIS) on Male Infertility NCT04193358 | Les Laboratoires des Médicaments Stériles | N/A |
| Terminated | Effect of Ejaculatory Abstinence on Semen Parameters in Male Factor Infertility Patients NCT04206800 | Boston IVF | N/A |
| Completed | The Role of Micro Nutrient Supplement in Improvement of the Sperm DNA Fragmentation NCT04509583 | Hue University of Medicine and Pharmacy | N/A |
| Unknown | Comparison of the Effect of Microchip and Density Gradient Methods in Intrauterine Insemination Cycles NCT04144244 | Bezmialem Vakif University | N/A |
| Unknown | Randomized, Standard-Controlled, Study to Evaluate the Ohana IVF Sperm Preparation Kit, SPeRtility IVF Next Ge NCT04142112 | Ohana BioSciences | N/A |
| Unknown | Selection of Non Apoptotic Human Sperm for in Vitro Fertilization by Using Magnetic Activated Cell Sorting (MA NCT03988361 | Universitair Ziekenhuis Brussel | — |
| Unknown | Sexual Counseling According to the PLISSIT Model in Primary Infertile Couples NCT04791683 | Istanbul University - Cerrahpasa | N/A |
| Completed | Sperm Separation Efficiency to Maximize Pregnancy Rates: MACS vs. FERTILE Chip NCT04061486 | Vida Recoletas Sevilla | — |
| Completed | Evaluation of Sperm Selection Technique Using Hyaluronic Acid Binding in Intra-cytoplasmic Sperm Injection (IC NCT03999372 | ClinAmygate | Phase 4 |
| Completed | The Evaluation of the Effect of Microfluidic Sperm Sorting Chip 'Labs-on-a-chip' on IVF Success in Male Factor NCT03960229 | Bezmialem Vakif University | N/A |
| Unknown | To Study the Effect of Magnetic Activated Sperm Sorting on the Outcome of in Vitro Fertilization-embryo Transp NCT03968367 | Li-jun Ding | N/A |
| Active Not Recruiting | Retrieval of Sperm From Men With Azoospermia Using Ultrasound-guided Rete Testis Aspiration NCT03291522 | University of Pittsburgh | — |
| Completed | BPA Levels Relationship With IVF/ICSI Outcomes in Patients With Male Factor NCT05224284 | Sanliurfa Mehmet Akif Inan Education and Research Hospital | N/A |
| Withdrawn | GnRH Agonist at Embryo Transfer: IVF Outcomes NCT03544073 | Maimonides Medical Center | Phase 3 |
| Unknown | Vitamin D and Human Sperm DNA Fragmentation NCT03829943 | Sanford Health | — |
| Unknown | Oral Dydrogesterone vs. Micronized Vaginal Progesterone for Luteal Phase Support in Frozen-thawed Embryo Trans NCT04124913 | Memorial Sisli Hospital, Istanbul | Phase 4 |
| Completed | Assessment of Seminal Levels of Cystatin C and Endoglin in Infertile Men With Varicocele NCT04856579 | Benha University | N/A |
| Unknown | Role of Nutritional Support in Idiopathic Male Infertility NCT03588949 | NATURAmedicatrix Sàrl | N/A |
| Unknown | Unraveling the Klinefelter's Disease Physiopathology NCT05997706 | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | N/A |
| Completed | Outcomes of Intra-Cytoplasmic Sperm Injection in Infertile Men With Non-tense Vaginal Hydrocele NCT03532386 | Tanta University | — |
| Completed | Sperm DNA Damage to Intracytoplasmic Sperm Injection Outcome NCT03129243 | Assiut University | — |
| Unknown | Oxidative Stress In Semen And Male Infertility NCT03464656 | Hamad Medical Corporation | Phase 4 |
| Completed | The Aim of This Study is to Determine the Incidence of Alterations in Fluorescent In Situ Hybridisation (FISH) NCT06524102 | Instituto de Investigación Sanitaria y Biomédica de Alicante | N/A |
| Completed | Sperm Phenotype and Differentially Methylated Regions NCT05461079 | University of Basel | — |
| Completed | Impact of DNA Fragmentation in Sperm on Pregnancy Outcome After Intra-uterine Insemination in a Spontaneous Cy NCT03319654 | University Hospital, Antwerp | N/A |
| Terminated | Impact of Escitalopram on Sperm DNA Fragmentation NCT03527043 | Weill Medical College of Cornell University | Phase 2 |
| Unknown | Preimplantation Genetic Screening in Patients With Male Factor Infertility NCT02941965 | International Peace Maternity and Child Health Hospital | N/A |
| Active Not Recruiting | Developmental Epidemiological Study of Children Born Through Reproductive Technology NCT03799107 | University of California, San Francisco | — |
| Completed | Sperm Selection by Microfluidic Separation Improves Embryo Quality NCT03085433 | University of California, San Francisco | N/A |
| Terminated | PKB171 Against Placebo in Couples With Asthenozoospermia Who Wish to Conceive NCT06986031 | Prokrea BCN, S.L. | Phase 2 |
| Unknown | IVF Outcomes After Varicocele Repair NCT03090438 | Shaare Zedek Medical Center | N/A |
| Completed | Reproductive Outcomes of Different Sperm Selection Techniques for ICSI Patients With Abnormal Sperm DNA Fragme NCT04482517 | Ganin Fertility Center | N/A |
| Completed | Denosumab and Male Infertility: a RCT NCT03030196 | Martin Blomberg Jensen | Phase 2 |
| Completed | Impact of Duloxetine on Male Fertility NCT03038867 | Weill Medical College of Cornell University | Phase 2 |
| Unknown | Attention to Variability During Infertility NCT03712982 | Harvard University | N/A |
| Completed | Modern Analyses of the Semen in Evaluating Male Fertility and Treatment Options of Male Infertility NCT02932865 | Turku University Hospital | — |
| Unknown | The Effect of Combination of Red and White Bahman Retrieved of Iranian Traditional Medicine on Semen Parameter NCT02998593 | Royan Institute | Phase 3 |
| Unknown | Role of FSHR Polymorphism p.N680S in the Therapy With FSH in Patients Who Underwent Varicocele Surgery NCT02719093 | U.O. Chirurgia Andrologica | Phase 4 |
| Completed | DNA Fragmentation - Effect on Pregnancy Rate NCT05397314 | Odense University Hospital | N/A |
| Completed | Oral Astaxanthin and Semen Quality, Fertilization and Embryo Development in Assisted Reproduction Techniques P NCT02310087 | University Medical Centre Ljubljana | N/A |
| Completed | 0.2 ml vs. 0.5 Inseminated Volume in Donor Intrauterine Insemination Cycles: A Prospective RCT NCT03006523 | Fundacion Dexeus | N/A |
| Completed | The Role of Artery-Preserving Varicocelectomy in Subfertile Men With Severe Oligozoospermia. NCT03344588 | Mansoura University | N/A |
| Completed | Effect of Long-time Human Sperm Storage in Liquid Nitrogen on Semen Parameters NCT06448000 | University Hospital, Clermont-Ferrand | — |
| Completed | Expressive Writing in Male Infertility NCT00385346 | University Hospital, Bonn | N/A |
| Completed | Testicular Versus Ejaculated Spermatozoa for IVF/ICSI in Men With High Sperm DNA Damage NCT02058082 | Mount Sinai Hospital, Canada | N/A |
| Completed | Menevit Study: Menevit Anti-Oxidant Therapy for the Treatment of Male Infertility NCT00100269 | Repromed | Phase 3 |
| Completed | Laser-Assisted Versus Conventional Intracytoplasmic Sperm Injection NCT00114725 | Shady Grove Fertility Reproductive Science Center | N/A |