NCT05847257

Impact of Co Enzyme Q10 as Adjuvant Therapy to Letrozole on Spermiogram

Impact of Co Enzyme Q10 as Adjuvant Therapy to Letrozole on Spermiogram and Sex Hormone in Iraqi Infertile Men; A Comparative Study

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 74 (actual)
• Sponsor: Al-Mustansiriyah University · Academic / Other
• Sex: Male
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

Worldwide infertility affects about 15 % of reproductive-age couples. In many cases, infertility can't be treated, new treatment options with promising value were involved in the recent clinical trials.

Detailed description

We will evaluate the impacts of adding coenzyme Q10 to letrozole on spermiogram and sex hormone in men diagnosed with idiopathic oligo/astheno/ teratozoospermia (iOAT) syndrome. The study will include 67 patients which will be randomly separated into two groups, Group (A) 29 patients will be treated with letrozole 2.5mg tablet orally twice a week, Group (B) 38 patient will be treated with a combination of letrozole 2.5 mg tablet orally twice a week plus Co-Q10 400mg per day, both groups complete treatment for three months. Semen sample, serum FSH, estradiol (E2), and testosterone (T) were analyzed at day one, and at the end of one, two, and three months.

Conditions

• Male Reproductive Problem
• Infertility, Male

Interventions

Type	Name	Description
DRUG	Letrozole tablets	letrozole 2.5mg twice weekly for 3 months
DIETARY_SUPPLEMENT	Coenzyme Q10 table	Coenzyme Q10 400 mg per day for 3 months

Timeline

• Start date: 2021-12-01
• Primary completion: 2022-10-30
• Completion: 2022-10-30
• First posted: 2023-05-06
• Last updated: 2025-02-19

Locations

1 site across 1 country: Iraq