NCT06177002

SARS-CoV-2, TESTOSTERONE AND MALE FRAGILITY

SARS-CoV-2, TESTOSTERONE AND MALE FRAGILITY (PROTEGGIMI): A MULTIDIMENSIONAL RESEARCH PROJECT

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 2,000 (estimated)
• Sponsor: IRCCS San Raffaele · Academic / Other
• Sex: Male
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The hormonal environment (steroid, primarily) could have a very relevant pathophysiological role in association with SARS-CoV-2. That is, testosterone could play a relevant role in leaving male subjects more exposed to infection and more prone to developing severe complications following COVID-19 infection.

Detailed description

Preliminary data suggests that male individuals are more susceptible to COVID-19 infection, at least in Western countries, and that their mortality rate is higher than female individuals. This would seem to suggest that the hormonal environment (steroid, primarily) could have a very relevant pathophysiological role in association with SARS-CoV-2. That is, testosterone could play a relevant role in leaving male subjects more exposed to infection and more prone to developing severe complications following COVID-19 infection. Another option is that COVID-19 infection could cause a condition of acute hypogonadism, following which, the exhaustion of androgenic action could act as a co-trigger of a severe or even fatal course of the disease.

Conditions

• COVID-19
• Testosterone Deficiency
• Infertility, Male

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Collection of biological data	Biological sample will be collected from the COVID19 patients and from healthy donors

Timeline

• Start date: 2020-05-19
• Primary completion: 2025-05-18
• Completion: 2025-05-18
• First posted: 2023-12-20
• Last updated: 2023-12-20

Locations

1 site across 1 country: Italy