| Withdrawn | Cell-Based Therapy for White Matter Repair in Periventricular Leukomalacia NCT06985303 | MGAM LLC | EARLY_Phase 1 |
| Not Yet Recruiting | Sildenafil Plus Hypothermia to Treat Neonatal Encephalopathy NCT06810284 | Assistance Publique - Hôpitaux de Paris | Phase 2 |
| Enrolling By Invitation | Real World Outcomes of Intranasal MuSE Exosomes and Stem Cells in Neurological Regenerative Therapy NCT07521384 | Healing Hope International | — |
| Recruiting | Intensive Multimodal Neurorehabilitation Targeting Neuroplasticity in Pediatric Neurodevelopmental and Chromos NCT07493096 | Healing Hope International | — |
| Not Yet Recruiting | Hydrogen In Neonatal Encephalopathy (HIE) Trial NCT07411911 | Boston Children's Hospital | Phase 1 |
| Not Yet Recruiting | A Study of a Blood Marker in Newborns With Brain Injury Caused by Lack of Oxygen at Birth NCT07292220 | Mustafa Gürkan | — |
| Enrolling By Invitation | A Safety and Feasibility Trial Protocol of Metformin in Infants After Perinatal Brain Injury NCT06429007 | Boston Children's Hospital | Phase 1 |
| Not Yet Recruiting | Nephroprotection Following Perinatal Asphyxia: Randomized Controlled Trial NCT07088328 | Alexandria University | N/A |
| Recruiting | The HIEnome Study: Genome Sequencing for Perinatal HIE NCT06762795 | Baylor College of Medicine | N/A |
| Not Yet Recruiting | Neuromotor Development and Motor Related Health Care in Children with a High Risk Neonatal Period NCT06645717 | Karolinska Institutet | — |
| Completed | The Effect of Maternal Scent and Knitted Octopus Application on Pain in Infants Diagnosed With Neonatal Asphyx NCT07526233 | Alev Sivasli | N/A |
| Recruiting | Dose Optimization of Caffeine for HIE NCT06448780 | University of North Carolina, Chapel Hill | Phase 1 |
| Completed | Monitoring After Cardiac Arrest: Electroencephalogram and Cerebral Oximetry in Predicting Outcome NCT06460480 | Haseki Training and Research Hospital | — |
| Withdrawn | PK and Safety of Caffeine in Neonates With Hypoxic Ischemic Encephalopathy Receiving Therapeutic Hypothermia NCT05295784 | University of Arkansas | Phase 1 |
| Unknown | Functional Imaging of Baby Brains NCT05514665 | Hamilton Health Sciences Corporation | — |
| Active Not Recruiting | Predicting Mortality in Patients With Return of Spontaneous Circulation After Cardiac Arrest NCT07020091 | Ahmet Düzgün | — |
| Unknown | Radiological Evaluation of Hypoxic Ischemic Encephalopathy NCT06145256 | Assiut University | — |
| Unknown | Umbilical Cord Abnormalities in the Prediction of Adverse Pregnancy Outcomes NCT05901688 | Medway NHS Foundation Trust | — |
| Recruiting | Assess Safety and Efficacy of Sovateltide in Hypoxic-ischemic Encephalopathy NCT05514340 | Pharmazz, Inc. | Phase 2 |
| Recruiting | A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of RLS-0071 in Newbor NCT05778188 | ReAlta Life Sciences, Inc. | Phase 2 |
| Unknown | Identification of a Pool of miRNA to Improve Early Management of Perinatal Asphyxia and Hypoxic Ischemic Encep NCT05986994 | Ospedale Buon Consiglio Fatebenefratelli | — |
| Completed | Hypothermia's Effect on Hepatitis B Vaccination NCT05787899 | Medical University of South Carolina | — |
| Recruiting | A Dose Escalation Study of Levetiracetam in the Treatment of Neonatal Seizures NCT05610085 | University of California, San Diego | Phase 2 |
| Active Not Recruiting | Comparative Outcomes Related to Delivery-room Cord Milking In Low-resourced Kountries NCT03657394 | Nemours Children's Clinic | N/A |
| Recruiting | Comparative Outcomes Related to Delivery-room Cord Milking In Low-resourced Kountries Developmental Follow Up NCT03682042 | Nemours Children's Clinic | N/A |
| Withdrawn | Umbilical Cord Milking in Neonates Who Are Depressed at Birth-Developmental Follow Up (MIDAB-FU) NCT03681314 | Nemours Children's Clinic | N/A |
| Recruiting | Effects of a Physical Therapy Intervention on Motor Delay in Infants Admitted to a Neonatal Intensive Care Uni NCT05568264 | Shirley Ryan AbilityLab | N/A |
| Withdrawn | Whole-Body Hypothermia for Neonates With Hypoxic-Ischemic Encephalopathy(HIE) NCT05581927 | Daping Hospital and the Research Institute of Surgery of the Third Military Medical University | N/A |
| Active Not Recruiting | Neonatal Seizure Registry, GEnetics of Post-Neonatal Epilepsy NCT05361070 | University of California, San Francisco | — |
| Recruiting | Spinal Stimulation and Mobility Devices NCT05520359 | University of Washington | N/A |
| Completed | Dexmedetomidine Use in Infants Undergoing Cooling Due to Neonatal Encephalopathy (DICE Trial) NCT04772222 | University of Utah | Phase 2 |
| Recruiting | Efficacy Evaluation of UCB-MNCs in the Treatment of Refractory Neonatal Diseases NCT06427642 | Shandong Qilu Stem Cells Engineering Co., Ltd. | N/A |
| Completed | Therapeutic Intervention Supporting Development From NICU to 6 Months for Infants Post Hypoxic-Ischemic Enceph NCT05130528 | University of Southern California | N/A |
| Completed | Umbilical Cord Milking Versus Immediate Cord Clamping in Full Term Neonates (≥ 37 Weeks) Requiring Resuscitati NCT06090968 | Lady Hardinge Medical College | N/A |
| Completed | RIC in HIE: A Safety and Feasibility Trial NCT05379218 | The Hospital for Sick Children | N/A |
| Completed | Effect of Non-nutritive Sucking on Transition to Oral Feeding in Infants With Asphyxia NCT05687708 | Medipol University | N/A |
| Recruiting | Hydrocortisone Therapy Optimization During Hypothermia Treatment in Asphyxiated Neonates NCT05836610 | Semmelweis University | Phase 4 |
| Unknown | Babies in Glasses; a Feasibility Study. NCT05048550 | Great Ormond Street Hospital for Children NHS Foundation Trust | N/A |
| Withdrawn | Maternal Hyperoxygenation for Intrapartum Fetal Heart Rate Tracing Abnormalities NCT03996317 | Loma Linda University | N/A |
| Not Yet Recruiting | Early Virtual Intervention for Infants With CP Following HIE Diagnosis NCT04913324 | The Hospital for Sick Children | N/A |
| Unknown | Protecting Brains and Saving Futures - the PBSF Protocol NCT03786497 | Protecting Brains Saving Futures | — |
| Unknown | THE ROLE OF CARDIAC MARKERS IN HYPOXIC ISCHEMIC ENCEPHALOPATHY IN LONG-TERM NEURODEVELOPMENTAL FOLLOW UP NCT04766541 | Hacettepe University | — |
| Completed | CEUS Evaluation of Hypoxic Ischemic Injury NCT03549520 | Children's Hospital of Philadelphia | Phase 3 |
| Withdrawn | Evaluation of Long-term Neurodevelopment in Neonatal Encephalopathy by Infant Treadmill NCT03527498 | Children's Hospital of Fudan University | N/A |
| Terminated | Evaluation of Long-Term Gait Development in Infants With Neonatal Encephalopathy Using Infant Treadmill NCT03534466 | Children's Hospital of Fudan University | N/A |
| Completed | The Effects of Minimal Enteral Nutrition on Mesenteric Blood Flow and Oxygenation in Neonates With HIE NCT06344286 | Istanbul Training and Research Hospital | N/A |
| Recruiting | Systemic Biomarkers of Brain Injury From Hyperammonemia NCT04602325 | Children's National Research Institute | — |
| Recruiting | Prognostic Factors to Regain Consciousness NCT04445649 | BDH-Klinik Hessisch Oldendorf | — |
| Completed | Neonatal Seizure Registry - Developmental Functional EValuation NCT04337697 | University of California, San Francisco | — |
| Recruiting | Healthy Little Eyes NCT05971446 | University of Wisconsin, Madison | — |
| Completed | Caffeine for Hypoxic-Ischemic Encephalopathy NCT03913221 | University of North Carolina, Chapel Hill | Phase 1 |
| Completed | Metabolic Monitoring During Therapeutic Hypothermia (Cooling) for Hypoxic Ischaemic Encephalopathy NCT06932354 | Kathryn Beardsall | N/A |
| Unknown | Use of Melatonin for Neuroprotection in Asphyxiated Newborns NCT03806816 | University Hospital of Ferrara | N/A |
| Completed | The Impact of Holding on Stress and Bonding in Mother-Infant Pairs During Therapeutic Hypothermia NCT03837717 | MaineHealth | N/A |
| Completed | Continous Renal Replacement Therapy With the CARPEDIEM® in a French National Cohort of 25 Neonates and Small I NCT05495607 | Centre Hospitalier Universitaire de Nice | — |
| Unknown | Individual Cerebral Hemodynamic Oxygenation Relationships (ICHOR 1) NCT06195345 | Children's Hospital Los Angeles | — |
| Completed | Bedside Optical Retinal Assessment of Hypoxic Ischemic Encephalopathy in Infants NCT03640494 | Duke University | — |
| Unknown | Feasibility and Safety of Umbilical Cord Blood Transfusion in the Treatment of Neonatal Cerebral Ischemia and NCT03352310 | Mononuclear Therapeutics Ltd. | Phase 1 |
| Unknown | Role of Umbilical Cord Milking in the Management of Hypoxic-ischemic Encephalopathy in Neonates NCT03123081 | Jubilee Mission Medical College and Research Institute | N/A |
| Unknown | Erythropoietin in Management of Neonatal Hypoxic Ischemic Encephalopathy NCT03163589 | Assiut University | Phase 3 |
| Completed | Propofol-induced EEG Changes in Hypoxic Brain Injury NCT03485781 | University of Oulu | — |
| Unknown | Heart Beat Variability in Neonatal Encephalopathy NCT03179553 | Imperial College London | — |
| Unknown | Role of Citicoline in Treatment of Newborns With Hypoxic Ischemic Encephalopathy NCT03181646 | Armed Forces Hospital, Pakistan | Phase 3 |
| Unknown | MRI of Neonate With HIE Before and During the Moderate Hypothermia NCT03079492 | First Affiliated Hospital Xi'an Jiaotong University | — |
| Terminated | Quantitative Assessment of Sucking for Early Diagnosis of Brain Injury in Infants at High Risk NCT03246243 | Boston Children's Hospital | — |
| Completed | Holding, Stress, and Bonding During Therapeutic Hypothermia NCT03079284 | Alexa Craig | N/A |
| Recruiting | Melatonin as a Neuroprotective Therapy in Neonates With HIE Undergoing Hypothermia NCT02621944 | University of Florida | EARLY_Phase 1 |
| Unknown | Hyperbaric Oxygen Therapy Improves Outcome of Hypoxic-Ischemic Encephalopathy NCT02894866 | Nanfang Hospital, Southern Medical University | N/A |
| Completed | Cerebral Oxymetry and Neurological Outcome in Therapeutic Hypothermia NCT03024021 | Tepecik Training and Research Hospital | — |
| Completed | PAEAN - Erythropoietin for Hypoxic Ischaemic Encephalopathy in Newborns NCT03079167 | University of Sydney | Phase 3 |
| Completed | Intra-operative Feed Back on Traction Force During Vacuum Extraction: Safe Vacuum Extraction Alliance NCT03071783 | Karolinska Institutet | N/A |
| Completed | Dexmedetomidine Pharmacokinetics in Neonates During Therapeutic Hypothermia NCT02529202 | Seattle Children's Hospital | EARLY_Phase 1 |
| Completed | Clinical Utility of Serum Biomarkers for the Management of Neonatal Hypoxic Ischemic Encephalopathy (Control L NCT02349672 | University of Florida | — |
| Completed | ANS Function in HIE Infants Treated With Therapeutic Hypothermia NCT06730490 | McGill University Health Centre/Research Institute of the McGill University Health Centre | — |
| Completed | Hydrocortisone Treatment In Systemic Low Blood Pressure During Hypothermia in Asphyxiated Newborns NCT02700828 | Semmelweis University | Phase 2 / Phase 3 |
| Unknown | Targeted Temperature Management After In-Hospital Cardiac Arrest NCT02578823 | Asan Medical Center | N/A |
| Withdrawn | Neuroprotective Effect of Autologous Cord Blood Combined With Therapeutic Hypothermia Following Neonatal Encep NCT02551003 | Children's Hospital of Fudan University | Phase 1 / Phase 2 |
| Completed | Reno-protective Effect of Brain Cooling in Newborn With Hypoxia NCT02683915 | Mansoura University Children Hospital | — |
| Completed | EEG Slow Wave Activity in Hypoxic Brain Injury NCT04506788 | University of Oulu | — |
| Completed | Preemie Hypothermia for Neonatal Encephalopathy NCT01793129 | NICHD Neonatal Research Network | N/A |
| Completed | Umbilical Cord Milking for Neonates With Hypoxic Ischemic Encephalopathy NCT02287077 | Thomas Jefferson University | N/A |
| Completed | Developmental Outcomes NCT02264808 | University of Florida | — |
| Completed | Autologous Cord Blood Cell Therapy for Neonatal Encephalopathy NCT02256618 | Neonatal Encephalopathy Consortium, Japan | Phase 1 |
| Completed | Clinical Trial of a New Rectum Cooling System on Patients of Hypoxic-ischemic Brain Damage NCT02544542 | Children's Hospital of Chongqing Medical University | N/A |
| Unknown | Umbilical Cord Derived Mesenchymal Stem Cells Therapy in Hypoxic Ischemic Encephalopathy NCT01962233 | Hebei Medical University | Phase 1 |
| Completed | Neonatal Erythropoietin And Therapeutic Hypothermia Outcomes in Newborn Brain Injury (NEATO) NCT01913340 | University of California, San Francisco | Phase 1 / Phase 2 |
| Completed | Efficacy of Erythropoietin to Improve Survival and Neurological Outcome in Hypoxic Ischemic Encephalopathy NCT01732146 | Assistance Publique - Hôpitaux de Paris | Phase 3 |
| Terminated | Topiramate in Neonates Receiving Whole Body Cooling for Hypoxic Ischemic Encephalopathy NCT01765218 | Kristin R Hoffman | Phase 1 / Phase 2 |
| Unknown | Neural Progenitor Cell and Paracrine Factors to Treat Hypoxic Ischemic Encephalopathy NCT02854579 | Navy General Hospital, Beijing | N/A |
| Completed | Prospective Research in Infants With Mild Encephalopathy NCT01747863 | McGill University Health Centre/Research Institute of the McGill University Health Centre | — |
| Completed | California Transport Cooling Trial NCT01683383 | Stanford University | N/A |
| Completed | Darbe Administration in Newborns Undergoing Cooling for Encephalopathy NCT01471015 | University of Utah | Phase 1 / Phase 2 |
| Completed | Protein Supplementation in Infants With Brain Injury NCT01936246 | Children's Hospital Medical Center, Cincinnati | N/A |
| Enrolling By Invitation | Florida Neonatal Neurologic Network NCT02260271 | University of Florida | — |
| Completed | Magnetic Resonance Imaging and Spectroscopy Biomarkers of Neonatal Hypoxic Ischemic Encephalopathy NCT01481207 | University Children's Hospital, Zurich | — |
| Completed | Autologous Cord Blood Cells for Brain Injury in Term Newborns NCT01649648 | National University Hospital, Singapore | Phase 1 |
| Completed | Study of Cerebrolysin for Treatment of Infants With History of Neonatal Hypoxic Ischemic Encephalopathy NCT01059461 | Sahar M.A. Hassanein, MD | Phase 2 |
| Terminated | Optimizing (Longer, Deeper) Cooling for Neonatal Hypoxic-Ischemic Encephalopathy(HIE) NCT01192776 | NICHD Neonatal Research Network | N/A |
| Withdrawn | MRI Thermal Imaging of Infants Undergoing Cooling for Hypoxic Ischemic Encephalopathy(HIE) NCT01128673 | Vanderbilt University | — |
| Completed | Safety and Efficacy of Topiramate in Neonates With Hypoxic Ischemic Encephalopathy Treated With Hypothermia NCT01241019 | Meyer Children's Hospital IRCCS | Phase 2 |
| Completed | Neonatal Erythropoietin in Asphyxiated Term Newborns NCT00719407 | University of California, San Francisco | Phase 1 |
| Unknown | Whole Body Cooling Using Phase Changing Material NCT01138176 | Robertson, Nicola, M.D. | Phase 1 / Phase 2 |
| Completed | Late Hypothermia for Hypoxic-Ischemic Encephalopathy NCT00614744 | NICHD Neonatal Research Network | N/A |
| Completed | Pilot Study of Head Cooling in Preterm Infants With Hypoxic Ischemic Encephalopathy NCT00620711 | Vanderbilt University | Phase 1 |
| Completed | Erythropoietin in Infants With Hypoxic Ischemic Encephalopathy (HIE) NCT00945789 | Tanta University | Phase 1 / Phase 2 |
| Completed | Neonatal Resuscitation in Zambia NCT00097097 | NICHD Global Network for Women's and Children's Health | Phase 3 |
| Completed | Ascorbic Acid and Ibuprofen in Infants With Hypoxic Ischemic Encephalopathy NCT00624871 | Al-Azhar University | N/A |
| Completed | Neurological Outcome After Erythropoietin Treatment for Neonatal Encephalopathy NCT00808704 | Zhengzhou University | Phase 1 / Phase 2 |
| Completed | Systemic Hypothermia Improves Outcome of Hypoxic-Ischemic Encephalopathy NCT00817401 | Zhengzhou University | Phase 1 / Phase 2 |
| Completed | Safety and Efficacy of Hypothermia to Treat Neonatal Hypoxic-Ischemic Encephalopathy NCT00890409 | Fudan University | Phase 3 |
| Completed | Moderate Hypothermia in Neonatal Hypoxic Ischemic Encephalopathy NCT02826941 | Medical University of South Carolina | Phase 2 |