| Not Yet Recruiting | Ultrasound (US) Guided External Ventricular Catheter Placement NCT06253858 | Milton S. Hershey Medical Center | N/A |
| Recruiting | Flow Detection in Open and Closed Shunt Valve Periods NCT07478926 | Rhaeos, Inc. | N/A |
| Recruiting | Crystallization of LA and Adjuvant Mixtures in Cerebrospinal Fluid NCT07442929 | Medical University Innsbruck | — |
| Not Yet Recruiting | Assessment of Flow in Cerebrospinal Fluid Shunts With a Second Generation Wireless Thermal Anisotropy Measurem NCT06409286 | Rhaeos, Inc. | — |
| Not Yet Recruiting | Assessment of CSF Shunt Flow During Activities of Daily Living and Sleep With a Thermal Measurement Device NCT07050628 | Rhaeos, Inc. | N/A |
| Not Yet Recruiting | Relationship Between Hydrocephalus and Endolymphatic Hydrops NCT07003152 | Sohag University | — |
| Not Yet Recruiting | Assessment of Flow in Cerebrospinal Fluid Shunts With a Wireless Thermal Anisotropy Measurement Device in Asym NCT06410885 | Rhaeos, Inc. | N/A |
| Recruiting | Assessment of CSF Shunt Flow and Headaches With a Thermal Measurement Device NCT06996600 | Rhaeos, Inc. | N/A |
| Recruiting | Light Therapy Device for Neonatal Intraventricular Hemorrhage Grade 3 and 4 NCT06797219 | Rutgers, The State University of New Jersey | N/A |
| Recruiting | VentricuLostomy AssoCiaTed InfeCtions (LACTIC): Focus on CSF Lactate and Sampling Site NCT07380477 | Rigshospitalet, Denmark | — |
| Completed | Assessment of CSF Shunt Flow in an Outpatient Setting with a Thermal Measurement Device NCT06753929 | Rhaeos, Inc. | N/A |
| Not Yet Recruiting | Late Post Traumatic Ventriculomegally Does it Requires CSF Diversion ? NCT06703164 | Assiut University | — |
| Recruiting | CoMind Early Feasibility Study NCT06368648 | CoMind Technologies Limited | — |
| Recruiting | Bactiseal Catheter Safety Registry Study NCT06276543 | Integra LifeSciences Corporation | — |
| Recruiting | Mechanisms of Brain-Heart Injury of Post-Intracranial Hemorrhage NCT06906432 | Beijing Tiantan Hospital | — |
| Terminated | Functional and Non-Functional CSF Shunt Flow Measured With a Second-Generation Wireless Thermal Device NCT06506045 | Rhaeos, Inc. | — |
| Completed | Flow Measurements in Functional CSF Shunts and Off-Shunt Locations with a Second-Generation Thermal Device NCT06524492 | Rhaeos, Inc. | — |
| Terminated | Measurements of CSF Shunts and Off-Shunt Locations With Wireless Thermal Anisotropy Measurement Devices NCT06513572 | Rhaeos, Inc. | — |
| Active Not Recruiting | First-in-human Trial of Home Brain Pressure Measured Using Kitea ICP Sensor, Placed During Hydrocephalus Shunt NCT06402786 | University of Auckland, New Zealand | N/A |
| Recruiting | Clinical Outcome in Patients With INPH NCT06428734 | Xuanwu Hospital, Beijing | — |
| Recruiting | Impact of Hypnosis for Performing Lumbar Infusion Tests NCT06419842 | Centre Hospitalier Universitaire, Amiens | N/A |
| Unknown | Role of Endoscopic Third Ventriculostomy in Management of Malfunctioning Ventriculoperitoneal Shunt NCT06341946 | Sohag University | N/A |
| Recruiting | Shunt-dependency After aSAH - Role of Early Hyperglycaemia in CSF and Blood NCT06486909 | Isabel Hostettler | — |
| Completed | The Role of Neurofilament Light (NfL) in Patients With Hydrocephalus NCT05399602 | University Hospital Hradec Kralove | N/A |
| Recruiting | Longitudinal Measurements of Flow in Cerebrospinal Fluid Shunts With a Wireless Thermal Anisotropy Measurement NCT06086561 | Rhaeos, Inc. | N/A |
| Recruiting | European Study of Prodromal iNPH NCT05910944 | Johan Virhammar | — |
| Recruiting | Formative Usability Assessment of Wireless Thermal Anisotropy Devices NCT06040697 | Rhaeos, Inc. | — |
| Recruiting | EVD Drainage Data and Intracranial Pressure (ICP) Measurements NCT05546996 | Baylor College of Medicine | N/A |
| Unknown | Characterization of Dynamic Stability in Normal Pressure Hydrocephalus and Parkinson's Disease NCT05998473 | Henri Mondor University Hospital | — |
| Completed | AI Assisted Reader Evaluation in Acute Computed Tomography (CT) Head Interpretation NCT06018545 | Oxford University Hospitals NHS Trust | — |
| Active Not Recruiting | Post Market Clinical Follow-up of CODMAN CERTAS Programmable Valve NCT05397106 | Integra LifeSciences Corporation | — |
| Recruiting | Neurosurgical Outcome Network NCT06724029 | Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta | — |
| Terminated | Pilot Study to Evaluate the CereVasc® EShunt® System in the Treatment of Communicating Hydrocephalus NCT05501002 | CereVasc Inc | N/A |
| Completed | Assessment of CSF Shunt Flow With Thermal Measurements B NCT05432986 | Rhaeos, Inc. | — |
| Unknown | Quantitative Pupillometry NCT05386303 | Nantes University Hospital | — |
| Active Not Recruiting | US Pilot Study of the CereVasc® eShunt® System in Normal Pressure Hydrocephalus NCT05232838 | CereVasc Inc | N/A |
| Unknown | Prediction Model of Improvement of Disturbance of Consciousness in Patients With Hydrocephalus After Shunt Ope NCT05237102 | Zhuohang Wang | N/A |
| Active Not Recruiting | Pilot Study of the CereVasc® eShunt® System in Normal Pressure Hydrocephalus NCT05250505 | CereVasc Inc | N/A |
| Unknown | Improvement of Peritoneal Catheter Placement in VPS With a Splitable Trocar NCT05476874 | Southern Medical University, China | Phase 1 / Phase 2 |
| Active Not Recruiting | Combined Flow and Pressure Study of Craniospinal Dynamic NCT05068128 | Centre Hospitalier Universitaire, Amiens | — |
| Completed | Assessment of CSF Shunt Flow With Thermal Measurements A NCT05015751 | Rhaeos, Inc. | — |
| Unknown | Clinical Observation of V-P Shunt and Application of "Three-step Disinfection" to Reduce Post-operative Infect NCT04785248 | Baiyun Liu | N/A |
| Completed | The Role of the Glymphatic System Avaluated Thourgh mr Imaging in the Diagnosis and Management of NPH NCT06857136 | Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta | — |
| Recruiting | Prophylactic Antibiotics Useful With Antibiotic Impregnated External Ventricular Drains (EVDs)? NCT05001750 | Montefiore Medical Center | Phase 1 |
| Recruiting | Safety and Performance of the Polaris® 24 Adjustable Valve System in Hydrocephalus Patients' Treatment NCT04746625 | Sophysa | — |
| Active Not Recruiting | Improving Infant Hydrocephalus Outcomes in Uganda NCT03650101 | Boston Children's Hospital | — |
| Active Not Recruiting | The ETCHES I Study (Endovascular Treatment of Communicating Hydrocephalus With an Endovascular Shunt) NCT04758611 | CereVasc Inc | N/A |
| Completed | Bactiseal Catheter Safety Registry in China NCT04496414 | Integra LifeSciences Corporation | — |
| Recruiting | HCRN Endoscopic Versus Shunt Treatment of Hydrocephalus in Infants NCT04177914 | University of Utah | Phase 3 |
| Unknown | Caregiver Burden and Anxiety in Mothers of Children With Hydrocephalus NCT05544279 | Cukurova University | N/A |
| Unknown | Endoscopic Third Ventriculostomy for Adults: A Prognostic Model for Success NCT04773938 | Rigshospitalet, Denmark | — |
| Unknown | Efficacy Study of Hydrocephalus Surgery by Methods of Neuroelectrophysiology NCT04363658 | Xiangya Hospital of Central South University | — |
| Completed | A Study on the Safety of Hakim Programmable Shunt System NCT04285489 | Integra LifeSciences Corporation | — |
| Completed | Intraoperative Ultrasound Guided Compared to Stereotactic Navigated Ventriculoperitoneal Shunt Placement NCT04450797 | University Hospital, Basel, Switzerland | N/A |
| Active Not Recruiting | MiDura-Study (Neuro-Patch in Duraplasty) NCT04189172 | Aesculap AG | — |
| Unknown | Impact of Cerebral Ventricular Dilatations and Cerebrospinal Fluid Pulsations on Periventricular White Matter NCT05825521 | Centre Hospitalier Universitaire, Amiens | N/A |
| Completed | CERTAS Programmable Valve Registry NCT04207229 | Integra LifeSciences Corporation | — |
| Recruiting | MR Evaluation of Cerebrospinal Fluid (CSF) Dynamics NCT04099823 | Mayo Clinic | N/A |
| Unknown | Value of MRI CSF Flowmetry in Assessment of Grey Zone Hydrocephalic Patients NCT04060810 | Assiut University | N/A |
| Active Not Recruiting | Hyperfine Portable MRI in Hydrocephalus and Other Conditions Prompting Outpatient Brain Imaging NCT04436068 | University of Pennsylvania | N/A |
| Completed | Danish RAndomized Trial of External Ventricular Drainage Cessation IN Aneurysmal Subarachnoid Haemorrhage NCT03948256 | Rigshospitalet, Denmark | N/A |
| Terminated | Neurosurgical Transitional Care Programme NCT03593330 | Barts & The London NHS Trust | N/A |
| Completed | Subgaleal Drains in Decompressive Craniectomies NCT03777774 | Universiti Sains Malaysia | N/A |
| Unknown | Brain Ultrasound in the Weaning of External Ventricular Leads NCT03531723 | University Hospital, Toulouse | — |
| Completed | Pupillometry : Predictive Indicator in External Ventricular Drain Clamping ? NCT03823430 | Association Pro-arte | — |
| Unknown | Linking Digital Smartphone Behaviour With Brain Function NCT03516162 | University of Zurich | — |
| Completed | Thermal Camera Detection of Ventriculoperitoneal Shunt Flow NCT03451669 | University of Pennsylvania | — |
| Completed | Dexmedetomidine and Propofol for Pediatric MRI Sedation NCT03513757 | Medical College of Wisconsin | Phase 4 |
| Terminated | A Secondary Study Evaluating Aqueduct's Smart External Drain (SED) NCT03471702 | Aqueduct Critical Care | N/A |
| Completed | The Usage of Telemetric Prechamber Sensor Reservoir in Management of Normal Pressure Hydrocephalus. Comparisso NCT06629168 | University Hospital Hradec Kralove | — |
| Completed | Pacifier Activated Device and Mother's Voice in Infants at High-risk for Cerebral Palsy NCT03230032 | Nationwide Children's Hospital | N/A |
| Completed | A Study Evaluate Aqueduct's Smart External Drain NCT03113799 | Aqueduct Critical Care | N/A |
| Completed | Comparison of Programmable and Non-programmable CSF Shunts Among Adult Hydrocephalus Patients With Different E NCT05534659 | Chang Gung Memorial Hospital | — |
| Completed | Early Ventriculo-peritoneal Shunt in Subarachnoid Patients With External Ventricular Drainage NCT04567277 | Mashhad University of Medical Sciences | N/A |
| Terminated | Study of Choroid Plexus Cauterization in Patients With Hydrocephalus NCT02900222 | Ronald Benveniste | N/A |
| Unknown | Simulation Efficacy in Neurosurgical Education NCT02988154 | Johannes Gutenberg University Mainz | — |
| Terminated | Strata Programmable CSF Shunt Valve Study NCT02737163 | Johns Hopkins All Children's Hospital | — |
| Withdrawn | Comparison of Optic Nerve Sheath Diameter Measured by Ultrasonography Before and After Ventriculoperitoneal Sh NCT02663947 | Yonsei University | — |
| Suspended | An Evaluation of Non-Invasive ICP Monitoring in Patients Undergoing Invasive ICP Monitoring Via an Intraparenc NCT02773888 | HeadSense Medical | N/A |
| Completed | Hydrocephalus iPad-App Based Intervention Study NCT03595033 | Children's Hospital Medical Center, Cincinnati | N/A |
| Terminated | Sonographic Monitoring of Weaning of Cerebrospinal Fluid Drainages NCT02408757 | Insel Gruppe AG, University Hospital Bern | — |
| Terminated | Isoflurane-induced Neuroinflammation in Children With Hydrocephalus NCT02512809 | Nationwide Children's Hospital | Phase 3 |
| Recruiting | NIRS Monitoring in Premature Infants NCT02601339 | Boston Children's Hospital | — |
| Unknown | The CSF Shunt Entry Site Trial NCT02425761 | Baylor College of Medicine | Phase 3 |
| Unknown | PatientSpot Formerly Known as ArthritisPower NCT03840928 | Global Healthy Living Foundation | — |
| Withdrawn | Effect of Intraventricular tPA Following Aneurysmal Subarachnoid Hemorrhage NCT01878136 | Rush University Medical Center | Phase 1 / Phase 2 |
| Completed | Noninvasive Intracranial Pressure and Hydrocephalus Patients NCT02404740 | University of Colorado, Denver | — |
| Unknown | Non-invasive Epicutaneous Transfontanel Intracranial Pressure Monitoring in Children Under the Age of One: a N NCT02775669 | University Clinic Frankfurt | — |
| Unknown | Fetal Endoscopic Surgery for Spina Bifida NCT03315637 | Hospital Universitari Vall d'Hebron Research Institute | N/A |
| Unknown | An Evaluation of a Non-invasive Brain Monitor NCT02775136 | HeadSense Medical | N/A |
| Terminated | Comparison of Continuous Non-Invasive and Invasive Intracranial Pressure Measurement NCT01863381 | LifeBridge Health | N/A |
| Unknown | Tablet-guided Versus Freehand (Tab-Guide) Ventriculostomy : Study Protocol to the Test Accuracy of Ventriculos NCT02048553 | University Hospital, Geneva | N/A |
| Unknown | CRT ShuntCheck "Fit & Function" Study NCT02067364 | NeuroDx Development | N/A |
| Terminated | Intraventricular Drain Insertion: Comparison of Ultrasound-guided and Landmark-based Puncture of the Ventricul NCT01973764 | Insel Gruppe AG, University Hospital Bern | N/A |
| Completed | Comparison of Continuous Noninvasive and Invasive Intracranial Pressure Measurement--Celda Infusion Subprotoco NCT01976559 | LifeBridge Health | N/A |
| Unknown | Randomized Controlled Trial of Shunt vs ETV/CPC for PIH in Ugandan Infants NCT01936272 | Boston Children's Hospital | Phase 3 |
| Completed | Guided Application of Ventricular Catheters NCT01811589 | Aesculap AG | N/A |
| Unknown | Comparison of Optic Nerve Sheath Diameter on Retrobulbar Ultrasonography Before and After Drainage of Cerebros NCT01865149 | Yonsei University | — |
| Terminated | Comparison of Optic Nerve Sheath Diameter on Retrobulbar Ultrasound Before and After Drainage of Cerebrospinal NCT01863329 | Yonsei University | — |
| Completed | Prevalence of Acute Critical Neurological Disease in Children: a Global Epidemiological Assessment NCT02381977 | University of Pittsburgh | — |
| Completed | Ventricular Size Involvement in Neuropsychological Outcomes in Pediatric Hydrocephalus NCT01797627 | University of Utah | — |
| Completed | Blood and Cerebrospinal Fluid for Pediatric Brain Tumor Research NCT01556178 | Ann & Robert H Lurie Children's Hospital of Chicago | — |
| Completed | ShuntCheck Versus Radionuclide in Evaluating Shunt Function in Symptomatic NPH Patients NCT01323764 | NeuroDx Development | Phase 4 |
| Completed | Role of Proteomics and Metallomics in Cerebral Vasospasm Following Subarachnoid Hemorrhage NCT01799018 | State University of New York - Upstate Medical University | — |
| Completed | Study of Shunt Flow Sensor Accuracy in Extra-ventricular Drains. NCT01108965 | Transonic Systems Inc. | — |
| Unknown | The Prediction of Intracranial Pressure and Clinical Outcome by Transcranial Doppler in Neurocritical Patients NCT00886054 | National Taiwan University Hospital | — |
| Completed | Optimizing Treatment of Post-hemorrhagic Ventricular Dilation in Preterm Infants NCT00875758 | Washington University School of Medicine | N/A |
| Completed | Monitoring Patient Cerebro-Spinal Fluid Drainage With an Ultrasonic Flow Sensor NCT00652197 | Transonic Systems Inc. | — |
| Withdrawn | Bench Study of Transcutaneous Hydrocephalic Shunt Flow Sensor Alignment Accuracy and Repeatability NCT00651950 | Transonic Systems Inc. | — |
| Withdrawn | Diagnosing Malfunctioning Hydrocephalic Shunt Valves With a Flow Sensor NCT00652249 | Transonic Systems Inc. | — |
| Terminated | ETV Versus Shunt Surgery in Normal Pressure Hydrocephalus NCT00946127 | Johns Hopkins University | — |
| Terminated | Assess Specific Kinds of Children Challenges for Neurologic Devices Study NCT01191307 | Carlos Pena, PhD, MS | — |
| Completed | Quality of Life in Elderly After Aneurysmal Subarachnoid Hemorrhage (SAH) NCT00692744 | University Hospital, Rouen | — |
| Completed | Study of Ultrasound of the Eye for Children With Suspected Shunt Failure NCT00743457 | Oregon Health and Science University | — |
| Completed | BIS Monitoring of Patients With Hydrocephalus NCT02575105 | Suez Canal University | — |
| Active Not Recruiting | Magnetic Resonance Elastography in Hydrocephalus NCT02230124 | Dartmouth-Hitchcock Medical Center | N/A |
| Completed | Brain Aneurysms: Utility of Cisternal Urokinase Irrigation NCT04792944 | University of Valencia | — |
| Completed | A Registry for Comparing Catheter-Related Infection Rates Among Various Shunt Systems in the Treatment of Hydr NCT00280904 | Codman & Shurtleff | — |
| Completed | A Study Comparing Two Treatments for Infants With Hydrocephalus NCT00652470 | The Hospital for Sick Children | Phase 2 |
| Completed | A Precision and Accuracy Study of the Codman Valve Position Verification (VPV) System. NCT00196196 | Codman & Shurtleff | Phase 3 |
| Completed | Impact of Ventricular Catheter Used With Antimicrobial Agents on Patients With a Ventricular Catheter NCT00286104 | Chinese University of Hong Kong | Phase 3 |
| Completed | Establishing the Physiology of Syringomyelia NCT00001327 | National Institute of Neurological Disorders and Stroke (NINDS) | — |
| Available | Expanded Access Protocol: Umbilical Cord Blood Infusions for Children With Brain Injuries NCT03327467 | Joanne Kurtzberg, MD | — |