Trials / Active Not Recruiting
Active Not RecruitingNCT03650101
Improving Infant Hydrocephalus Outcomes in Uganda
Improving Infant Hydrocephalus Outcomes in Uganda: Predicting Developmental Outcomes and Identifying Patients at Risk for Early Treatment Failure After ETV/CPC
- Status
- Active Not Recruiting
- Phase
- —
- Study type
- Observational
- Enrollment
- 400 (estimated)
- Sponsor
- Boston Children's Hospital · Academic / Other
- Sex
- All
- Age
- 1 Day – 180 Days
- Healthy volunteers
- Not accepted
Summary
Neonatal postinfectious hydrocephalus (PIH) is a major public health problem in East Africa.The standard treatment has long been placement of a ventriculoperitoneal shunt (VPS) but these devices require life-long maintenance and nearly all fail multiple times. Endoscopic Third Ventriculostomy (ETV) with Choroid Plexus Cauterization (ETV/CPC) is an alternate treatment to give patients a shunt-free life. In this study, the investigators aim to optimize the metrics of evaluation as quantitative prognostic indicators of treatment response and long term outcomes.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | ETV/CPC | The Endoscopic Third Ventriculostomy/Choroid Plexus Cauterization (ETV/CPC) will comprise a standard frontal approach with flexible endoscopy. |
Timeline
- Start date
- 2021-05-05
- Primary completion
- 2025-05-15
- Completion
- 2027-12-01
- First posted
- 2018-08-28
- Last updated
- 2026-03-18
Locations
3 sites across 3 countries: United States, Canada, Uganda
Source: ClinicalTrials.gov record NCT03650101. Inclusion in this directory is not an endorsement.