| Not Yet Recruiting | Novel Indenoisoquinolone CMYC/TOPOISOMERASE 1 Inhibitor (LMP744) in Recurrent Glioblastoma NCT07416188 | National Institute of Neurological Disorders and Stroke (NINDS) | Phase 1 / Phase 2 |
| Recruiting | Evaluation of 18F-Fluciclovine Positron Emission Tomography - Magnetic Resonance Imaging (PET-MRI) in LGG NCT05555550 | Children's Hospital of Philadelphia | EARLY_Phase 1 |
| Not Yet Recruiting | A Phase I/IIa Study of C5252 in Patients With Intracranial Tumor NCT07243340 | ImmVira Pharma Co. Ltd | Phase 1 / Phase 2 |
| Recruiting | CUE-102 in Recurrent Glioblastoma NCT06917885 | David Reardon, MD | Phase 1 |
| Recruiting | Imaging of Solid Tumors Using 18F-TRX NCT06942104 | Rahul Aggarwal | Phase 1 |
| Recruiting | Repeated Neural Stem Cell Based Virotherapy for Newly Diagnosed High Grade Glioma NCT06169280 | Northwestern University | Phase 1 |
| Not Yet Recruiting | Integrated Analysis of Therapy Response and Resistence in Embryonal Tumors and Gliomas NCT06323408 | University Hospital Regensburg | — |
| Recruiting | PrOton Pulsed reduCed dOse Rate Radiotherapy for Recurrent CNS maligNancies Trial NCT06397560 | Baptist Health South Florida | N/A |
| Recruiting | Window of Opportunity Study of DSP-0390 in Gliomas NCT06636162 | Washington University School of Medicine | EARLY_Phase 1 |
| Recruiting | Safety and Tolerability of TNG456 Alone and in Combination With Abemaciclib in Patients With Solid Tumors With NCT06810544 | Tango Therapeutics, Inc. | Phase 1 / Phase 2 |
| Not Yet Recruiting | Niraparib and Temozolomide in Patients Glioblastoma NCT06258018 | Armando Santoro, MD | Phase 1 / Phase 2 |
| Not Yet Recruiting | In Vitro Models From Pediatric Brain Tumors NCT06499636 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | — |
| Recruiting | Clinical Study on the Safety and Efficacy of TS-2021 in the Treatment of Recurrent Malignant Glioma NCT06585527 | Beijing Neurosurgical Institute | Phase 1 |
| Recruiting | 18F-Fluciclovine PET-MRI in High-grade Glioma NCT05553041 | Children's Hospital of Philadelphia | EARLY_Phase 1 |
| Recruiting | Efficacy of a Mixed Distancial Neuropsychological Rehabilitation Program in Patients With Grade 2 or 3 Diffuse NCT06468176 | Institut du Cancer de Montpellier - Val d'Aurelle | N/A |
| Recruiting | Personalized Rendering of Motor System Functional Plasticity Potential to Improve Glioma Resection and Quality NCT06381726 | University of Milan | N/A |
| Recruiting | Monitoring of Patients With Diffuse Gliomas Using Circulating miRNAs NCT06203496 | University Hospital, Caen | — |
| Recruiting | FET PET in Differentiating Tumour Progression From Pseudoprogression in High Grade Glioma NCT06172595 | Singapore General Hospital | Phase 2 |
| Unknown | Efficacy and Safety of Rivaroxaban in the Prevention of Venous Thromboembolism in Glioma Patients NCT06196918 | Nanfang Hospital, Southern Medical University | N/A |
| Terminated | Prospective Evaluation of AI R&D Tool in Adult Glioma and Other Primary Brain Tumours (PEAR-GLIO) NCT06038760 | Ourotech, Inc. | — |
| Active Not Recruiting | ETAPA I: Peptide-based Tumor Associated Antigen Vaccine in GBM NCT05283109 | Mustafa Khasraw, MBChB, MD, FRCP, FRACP | Phase 1 |
| Withdrawn | Monocyte Antigen Carrier Cells for Newly Diagnosed GBM NCT04741984 | Michael Gunn | Phase 1 |
| Unknown | Social Cognition and Language in Patients With Gliomas NCT05764460 | University Medical Center Groningen | — |
| Recruiting | Surgical Tissue Flap to Bypass the Blood Brain Barrier in Glioblastoma NCT05954858 | Northwell Health | N/A |
| Not Yet Recruiting | 5-Aminolevulinic Acid (5-ALA) Gliolan®: Usage Increase Proposal for Neurosurgical Procedures in High-Grade Gli NCT05850377 | Sociedad de Lucha Contra el Cáncer del Ecuador | — |
| Active Not Recruiting | Niraparib In Recurrent IDH 1/2 Gliomas NCT05406700 | Massachusetts General Hospital | EARLY_Phase 1 |
| Recruiting | Superselective Intra-arterial Cerebral Infusion of Temsirolimus in HGG NCT05773326 | Nader Sanai | EARLY_Phase 1 |
| Suspended | GRETeL: Tumor Response to Standard Radiotherapy and TMZ Patients With GBM NCT05695976 | Duke University | — |
| Recruiting | Omental Tissue Autograft in Human Recurrent Glioblastoma Multiforme (rGBM) NCT05979064 | Northwell Health | N/A |
| Terminated | Oral AMXT 1501 Dicaprate in Combination With IV DFMO NCT05500508 | Aminex Therapeutics, Inc. | Phase 1 / Phase 2 |
| Unknown | Neoantigens Phase I Trial in Newly Diagnosed Glioblastoma Patients NCT05557240 | Shanghai 10th People's Hospital | N/A |
| Suspended | General Anesthesia Versus Awake Surgery in Resection of Gliomas and Metastases of Motor Areas NCT05485038 | Sklifosovsky Institute of Emergency Care | N/A |
| Recruiting | Concurrent Fluorescence and Sonographically Guided Eradication of Contrast-enhancing Gliomas and Metastases NCT05474573 | Sklifosovsky Institute of Emergency Care | N/A |
| Not Yet Recruiting | Establishing Radiolabelled PSMA as a Target for Glioma Treatment NCT05263466 | King's College Hospital NHS Trust | N/A |
| Not Yet Recruiting | ERC1671 to Treat Malignant Gliomas When Given in Combination With GM-CSF, Cyclophosphamide, Bevacizumab and Pe NCT05366062 | Epitopoietic Research Corporation | Phase 2 |
| Completed | Temporally-modulated Pulsed Radiation Therapy (TMPRT) After Prior EBRT for Recurrent IDH-mutant Gliomas NCT05393258 | Washington University School of Medicine | N/A |
| Recruiting | Safety and Tolerability of Fb-PMT in Recurrent Glioblastoma NCT05226494 | NanoPharmaceuticals LLC | Phase 1 |
| Active Not Recruiting | AZD1390 in Recurrent and Newly Diagnosed WHO Grade 4 Glioma Patients NCT05182905 | Nader Sanai | EARLY_Phase 1 |
| Unknown | Mapping of Tumor Stem Cells in the Resection Marigin During Extirpation of Highly Malignant Gliomas Using Glio NCT05556486 | Karolinska University Hospital | — |
| Recruiting | Repeated Superselective Intraarterial Cerebral Infusion (SIACI) of Bevacizumab With Temozolomide and Radiation NCT05271240 | Northwell Health | Phase 3 |
| Active Not Recruiting | An Integrated Radio-immunological Approach NCT05267509 | Istituto Oncologico Veneto IRCCS | — |
| Active Not Recruiting | 18F-FET-PET/MRI vs Standard MRI Alone for Stereotactic RadioTherapy Planning for High Grade Brain Gliomas NCT06499831 | Sunnybrook Health Sciences Centre | N/A |
| Active Not Recruiting | Intraoperative Rapid Diagnosis of Glioma Based on Fusion of Magnetic Resonance and Ultrasound Imaging NCT05656053 | Mingge LLC | — |
| Active Not Recruiting | Trial of Niraparib in Participants With Newly-diagnosed Glioblastoma and Recurrent Glioma NCT05076513 | Nader Sanai | EARLY_Phase 1 |
| Completed | Assessment of Safety and Feasibility of ExAblate Blood-Brain Barrier (BBB) Disruption in GBM Patients NCT04998864 | InSightec | — |
| Completed | Multi-center Research Project for Glioma Molecular Pathology Intraoperative Rapid Detection NCT04904419 | Jinsong Wu | — |
| Terminated | Incidence of Intracranial Hemorrhage in Glioma Patients With Venous Thromboembolism Converted From LMWH to Api NCT04895553 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | — |
| Recruiting | Phase 1 Trial of D2C7-IT in Combination With 2141-V11 for Recurrent Malignant Glioma NCT04547777 | Darell Bigner | Phase 1 |
| Terminated | Convection-enhanced Delivery of OS2966 for Patients With High-grade Glioma Undergoing a Surgical Resection NCT04608812 | OncoSynergy, Inc. | Phase 1 |
| Completed | Modulation of Ciliogenesis in Glioma Stem Cells NCT05772767 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | N/A |
| Terminated | Study of NUV-422 in Adults With Recurrent or Refractory High-grade Gliomas and Solid Tumors NCT04541225 | Nuvation Bio Inc. | Phase 1 |
| Completed | Effect of Perampanel on Peritumoral Hyperexcitability in HGG NCT04497142 | Dana-Farber Cancer Institute | Phase 1 / Phase 2 |
| Unknown | Role of Surgery in Treatment of Recurrent Brian Glioma:Prognostic Factors and Outcome NCT04562077 | Assiut University | — |
| Unknown | HSRT and IMRT Chemoradiotherapy for Newly Diagnosed GBM NCT04547621 | Huashan Hospital | Phase 1 / Phase 2 |
| Completed | Predictive Values of Preoperative [68Ga]Ga-PSMA-11 PET/CT in Patients With Suspected Brain Tumours of Glial Or NCT05896449 | Medical University of Warsaw | N/A |
| Unknown | The Efficacy and Safety of Brain-targeting Immune Cells (EGFRvIII-CAR T Cells) in Treating Patients With Lepto NCT05063682 | Chembrain LTD | Phase 1 |
| Suspended | Laparoscopically Harvested Omental Free Tissue Autograft to Bypass the Blood Brain Barrier (BBB) in Human Recu NCT04222309 | Northwell Health | Phase 1 |
| Completed | Evaluate the Safety and Effectiveness of Intranasal Administration of Temozolomide in Patients With Glioblasto NCT04091503 | Center Trials & Treatment Europe | Phase 1 |
| Completed | Molecular Pathology Research Project of Glioma NCT04924127 | Jinsong Wu | — |
| Completed | Glioma: Biomolecular Aspects NCT05806619 | Regina Elena Cancer Institute | — |
| Active Not Recruiting | Radiomics-Based Visualization and Quantitative Validation of IDH1 Heterogeneity in Gliomas NCT05969691 | Mingge LLC | N/A |
| Unknown | Grafts of GSCs Into Brain Organoids for Testing Anti-invasion Drugs NCT05772741 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | N/A |
| Completed | Assessing the Effectiveness of 2D Non-Navigated Intraoperative Ultrasound in Glioma Surgery NCT05873946 | Hospital del Rio Hortega | — |
| Unknown | Combination of Immunization and Radiotherapy for Malignant Gliomas (InSituVac1) NCT03392545 | Beijing Tiantan Hospital | Phase 1 |
| Completed | SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies fo NCT03434262 | St. Jude Children's Research Hospital | Phase 1 |
| Completed | GMCI, Nivolumab, and Radiation Therapy in Treating Patients With Newly Diagnosed High-Grade Gliomas NCT03576612 | Candel Therapeutics, Inc. | Phase 1 |
| Terminated | ONC201 in Pediatric H3 K27M Gliomas NCT03416530 | Jazz Pharmaceuticals | Phase 1 |
| Completed | Clinical Evaluation of Genetron TERT PCR Kit in Glioma Patients NCT05100602 | Genetron Health | — |
| Completed | Clinical Evaluation of Genetron IDH1 PCR Kit in Glioma Patients NCT05100173 | Genetron Health | — |
| Available | Glioblastoma and Individualized Therapies NCT05356312 | Zentrum fur Humangenetik Tuebingen | — |