NCT05393258

Temporally-modulated Pulsed Radiation Therapy (TMPRT) After Prior EBRT for Recurrent IDH-mutant Gliomas

A Pilot Study of Temporally-modulated Pulsed Radiation Therapy to Reirradiate Recurrent IDH-mutant Gliomas After Prior External Beam Radiation Therapy

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 13 (actual)
• Sponsor: Washington University School of Medicine · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This clinical trial studies the side effects of temporally-modulated pulsed radiation therapy (TMPRT) in patients with IDH-mutant gliomas who have previously received radiation therapy to the brain. TMPRT is a radiation technique in which radiation is delivered in multiple small doses on a specific timed interval, instead of delivering one large dose at one time. This technique may improve efficacy while reducing toxicity and improving patient quality of life.

Conditions

• Astrocytoma
• Oligodendroglioma, Adult
• Glioma, Malignant

Interventions

Type	Name	Description
RADIATION	temporally-modulated pulsed radiotherapy (TMPRT)	Intensity modulated RT (IMRT) using single or two arc therapy will be used for RT delivery.

Timeline

• Start date: 2022-06-28
• Primary completion: 2026-03-13
• Completion: 2026-03-13
• First posted: 2022-05-26
• Last updated: 2026-03-17

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated device study