Trials / Unknown
UnknownNCT05772741
Grafts of GSCs Into Brain Organoids for Testing Anti-invasion Drugs
Grafts of Patient-derived Glioblastoma Stem Cells Onto Autologous Brain Organoids. A Precision Medicine Model for Testing Drugs Against Tumor Invasion
- Status
- Unknown
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 160 (estimated)
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
In patients operated for glioblastoma, glioma stem-like cell lines will be obtained from tumor tissue, and IPSCs from skin fibroblasts or PBMCs. Brain organoids will be generated from IPSCs and co-cultured with IPSCs to study brain invasion and ciliogenesis. 3D genome architecture of glioma stem-like cells will be investigated. Gene modulation and pharmacologic strategies to inhibit invasion and restore ciliogenesis will be explored.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | Biological sample collection | Collection of biological samples |
Timeline
- Start date
- 2018-12-03
- Primary completion
- 2023-12-31
- Completion
- 2023-12-31
- First posted
- 2023-03-16
- Last updated
- 2023-03-16
Locations
1 site across 1 country: Italy
Source: ClinicalTrials.gov record NCT05772741. Inclusion in this directory is not an endorsement.