| Recruiting | PRospective Registry of Esophageal Motility NCT07506746 | IRCCS San Raffaele | — |
| Recruiting | A Randomized, Three-Arm Study Comparing Vonaprazan 10 mg, Vonaprazan 20 mg, and Esomeprazole 40 mg for the Hea NCT06953986 | Asian Institute of Gastroenterology, India | N/A |
| Not Yet Recruiting | Endoscopic Band Ligation for Treating Reflux Disease NCT06126055 | El Katib Hospital | N/A |
| Recruiting | Utility of Mucosal Impedance Device in Chronic Esophageal Disorders: NCT07227506 | Medical College of Wisconsin | — |
| Recruiting | Pharmacokinetics, Bioequivalence, and Safety Study of Trimedat® 76,95 mg Orally Disintegrating Tablets and Tri NCT07421011 | Valenta Pharm JSC | Phase 1 |
| Recruiting | Heartburn, Gastroesophageal Reflux Disease NCT07268820 | Incheon St.Mary's Hospital | Phase 4 |
| Recruiting | Vonaprazan Versus Esomeprazole for Healing of LA Grade B or Higher Esophagitis After POEM NCT06955520 | Asian Institute of Gastroenterology, India | N/A |
| Recruiting | Alginate vs Sucralfate for GERD Symptomatic Relief NCT07310927 | CMH Lahore Medical College and Institute of Dentistry | Phase 2 / Phase 3 |
| Recruiting | Anti-Reflux Endoscopic Therapy Using Argon Plasma Coagulation (AREA) in Gastroesophageal Reflux Disease (GERD) NCT06641375 | Asian Institute of Gastroenterology, India | N/A |
| Recruiting | Effect of Helicobacter Pylori Eradication on Gastroesophageal RefIux Disease (GERD) NCT06457334 | Assiut University | — |
| Completed | Efficacy and Safety of Combined Thread Embedding Acupuncture With Auricular Acupuncture for GERD NCT06157424 | University of Medicine and Pharmacy at Ho Chi Minh City | N/A |
| Recruiting | Famotidine and Antacids for Treatment of Dyspepsia NCT06241183 | Stony Brook University | Phase 4 |
| Completed | A Study to Compare Pharmacokinetics, Pharmacodynamics and Safety of UI059 and UIC202201 in Healthy Subjects NCT06141577 | Korea United Pharm. Inc. | Phase 1 |
| Recruiting | Prospective Evaluation of PH-impedance Tracings According to the Wingate Consensus, and Influence on GERD Clas NCT06084572 | Universitair Ziekenhuis Brussel | — |
| Recruiting | Mesh Vs Pledgets for Repair of Paraesophageal Hernia NCT05974722 | David Krpata | N/A |
| Active Not Recruiting | Biological Sample Repository for Gastrointestinal Disorders NCT05874726 | Pichamol Jirapinyo, MD, MPH | — |
| Completed | Role of ARMA in Selective Subset of Refractory GERD Patients. NCT05899491 | Asian Institute of Gastroenterology, India | N/A |
| Completed | Effectiveness of Modified Diaphragmatic Training for Gastroesophageal Reflux Disease Post Covid-19 NCT05833243 | Indonesia University | N/A |
| Completed | Investigate Linaprazan Glurate/Linaprazan in Healthy Subjects NCT05742984 | Cinclus Pharma Holding AB | Phase 1 |
| Unknown | Development of Machine Learning Models for the Prediction of BMI and Complications After Bariatric Surgery (CA NCT05710913 | Dr. Med Anas Taha | — |
| Unknown | Can EndoFLIP Improve Quality of Life Before and After Fundoplication? NCT06159972 | Dr. Wiley Chung | N/A |
| Terminated | Systems Biology of Gastrointestinal and Related Diseases NCT05579444 | Viome | — |
| Completed | Sleeve Gastrectomy With Cruroplasty and Omental Rape for Treatment of Morbid Obesity With Reflux Disease NCT05590208 | Minia University | N/A |
| Unknown | Gastric Neuromuscular Function in GERD NCT05719168 | The Functional Gut Clinic | N/A |
| Terminated | Comparison of the Sleeve Gastrectomy Technique With a Nissen Fundoplication Added to the Conventional Sleeve G NCT04626232 | University Hospital, Montpellier | N/A |
| Recruiting | Stretta Versus Conservative Treatment NCT05781347 | Military University Hospital, Prague | N/A |
| Unknown | A Study to Investigate the Pharmacokinetics and ECG Effects of Linaprazan Glurate NCT05469854 | Cinclus Pharma AG | Phase 1 |
| Unknown | Non-endoscopic Esophageal Sampling to Detect Barrett's Esophagus and Esophageal Cancer in Veterans NCT05210049 | Louis Stokes VA Medical Center | N/A |
| Unknown | A Novel Endoloop Pre-test to Treat Gastroesophageal Reflux NCT05192538 | Affiliated Hospital to Academy of Military Medical Sciences | N/A |
| Unknown | Ablation of Esophageal Inlet Patches in Patients Referred for Bravo pH-Testing NCT05131932 | Assaf-Harofeh Medical Center | N/A |
| Unknown | A Study to Evaluate the PK, PD and Safety of CKD-382 in Healthy Subjects NCT05108038 | Chong Kun Dang Pharmaceutical | Phase 1 |
| Completed | Acoustic Cough Monitoring for the Management of Patients With Known Respiratory Disease NCT05042063 | Clinica Universidad de Navarra, Universidad de Navarra | — |
| Completed | Long-term Follow-up After Hiatal Hernia Repair by Tension-free Mesh Closure or Simple Suturing NCT05069493 | Karolinska University Hospital | — |
| Withdrawn | Endoscopic Cardiac Band Ligation for the Management of Refractory GERD After Laparoscopic Sleeve Gastrectomy NCT04771247 | Johns Hopkins University | N/A |
| Recruiting | Truncal Vagotomy in Patients Undergoing Revisional Sleeve Gastrectomy to Gastric Bypass NCT04901429 | Baylor Research Institute | N/A |
| Unknown | Nissen Sleeve by Single Port With Magnetic Assistance NCT04931706 | Unidad Internacional de Cirugia Bariatrica y Metabolica | — |
| Recruiting | Analysis of Prevalence and Risk Factors Associated With Gastroesophageal Reflux Disease and Esophagitis After NCT05080634 | Maria Sklodowska-Curie National Research Institute of Oncology | — |
| Recruiting | 9-Step Magnetic Bariatric Revisional Surgery NCT04945304 | Unidad Internacional de Cirugia Bariatrica y Metabolica | — |
| Completed | A Study to Investigate the Effect of Food on the PK, PD of CKD-381 in Healthy Volunteers NCT04830930 | Chong Kun Dang Pharmaceutical | Phase 1 |
| Unknown | Recovering Damaged Cells for Sequelae Caused by COVID-19, SARS-CoV-2 NCT04846010 | All Natural Medicine Clinic, LLC | Phase 1 / Phase 2 |
| Unknown | Comorbid Esophageal Disorders in IBS Patients NCT04759378 | Assiut University | N/A |
| Unknown | Endoscopic Surgery for Gastrointestinal Disorders: A Multicenter Registry Study NCT05041608 | Advanced Endoscopy Research, Robert Wood Johnson Medical School Rutgers University | — |
| Completed | A Study to Compare PK, PD and Safety of UI058 and UIC202004 in Healthy Subjects NCT05282914 | Korea United Pharm. Inc. | Phase 1 |
| Active Not Recruiting | Multicenter Single-Blind RCT of CTIF Versus LNF For Treatment of GERD in Patients Requiring Hiatal Hernia Repa NCT04795934 | Mayo Clinic | N/A |
| Completed | GERD After Sleeve Gastrectomy NCT05178446 | University of Foggia | — |
| Completed | MCT and Capsaicin Provocation Challenge in Diagnosis of Chronic Cough NCT03363698 | Medical University of Warsaw | — |
| Unknown | Study Comparing the Effect of Ligamentum Teres Cardiopexy on de Novo GERD Post LSG NCT04652336 | GEM Hospital & Research Center | N/A |
| Active Not Recruiting | Gracie Diet for Gastroesophageal Reflux Disease NCT04360252 | Johns Hopkins University | N/A |
| Completed | Physiology of GERD and Treatment Response NCT04292470 | University of California, Davis | N/A |
| Withdrawn | Sensitivity and Specificity of the Modified Helicobacter Test INFAI NCT04294823 | International Pharmaceutical Consultancy | — |
| Unknown | A Study to Compare PK, PD and Safety of CKD-382 in Healthy Subjects NCT04703374 | Chong Kun Dang Pharmaceutical | Phase 1 |
| Completed | Patient Acceptance and Preference Among Screening Modalities for Detection of Barrett's Esophagus NCT04301986 | University of North Carolina, Chapel Hill | N/A |
| Withdrawn | Whether Proton Pump Inhibitors, Administered Prior to or After Surgery, Can Reduce the Incidence and/or Severi NCT03488147 | Icahn School of Medicine at Mount Sinai | Phase 2 |
| Completed | Laparoscopic Total Left-sided Surgical Approach Versus Traditional Bilateral Surgical Approach for Hiatal Hern NCT06828627 | Beijing Friendship Hospital | N/A |
| Recruiting | Functional Changes in the Stomach and Esophagus After One Anastomosis Gastric Bypass- OAGB NCT04422405 | Spital Limmattal Schlieren | N/A |
| Completed | Endoscopic Esophageal Topography (Endoflip 2.0) Versus High-resolution Manometry (HRM) NCT05089929 | Ohio State University | — |
| Recruiting | Real-life Study of Changes of Gastroesophageal Reflux Disease Manifestations Due to Behavioural and Diet Adher NCT04255693 | Federal State Budgetary Scientific Institution "Federal Research Centre of Nutrition, Biotechnology | N/A |
| Unknown | Study of Dietary Patterns and Food Diversity in Russian GERD Patients NCT04252144 | Russian Academy of Medical Sciences | N/A |
| Completed | Post-POEM GERD in Patients Undergoing Conventional Versus Oblique Fibers Sparing Posterior Myotomy for Achalas NCT04229342 | Asian Institute of Gastroenterology, India | N/A |
| Completed | Clinical Trial to Evaluate the Safety and Efficacy of JP-1366 in Patients With Erosive Gastroesophageal Reflux NCT04282954 | Onconic Therapeutics Inc. | Phase 2 |
| Completed | Effectiveness of Diaphragmatic Breathing on Reflux Symptoms in Outpatients NCT04120025 | Mayo Clinic | N/A |
| Completed | ANTI REFLUX MUCOSAL ABLATION THERAPHY (ARMA) NCT04243668 | Asian Institute of Gastroenterology, India | N/A |
| Completed | Clinical Trial to Assess the PK/PD of YYD601 20mg After Oral Administration if Healthy Adult Subjects (Phase1) NCT03985319 | Yooyoung Pharmaceutical Co., Ltd. | Phase 1 |
| Unknown | Citalopram for Reflux Hypersensitivity and Functional Heartburn NCT03499171 | Universitaire Ziekenhuizen KU Leuven | Phase 4 |
| Terminated | Effectiveness of Vonoprazan vs Omeprazole as Empiric Therapy for Gastroesophageal Reflux Disease (GERD) Patien NCT04028466 | St. Luke's Medical Center, Philippines | Phase 4 |
| Recruiting | The Effect of the Reflux Band™ Upper Esophageal Sphincter (UES) Assist Device on Reflux for Lung Transplant Re NCT03886961 | University of Florida | N/A |
| Active Not Recruiting | Long Term Outcomes of Bariatric Patients Treated With Surgery or Endoscopy NCT03705416 | Johns Hopkins University | — |
| Completed | One Anastomosis Gastric Bypass With Excluded Stomach Fundoplication: FundoRing vs Nissen vs OAGB Without Fundo NCT04828733 | The Society of Bariatric and Metabolic Surgeons of Kazakhstan | N/A |
| Unknown | Prucalopride Treatment for Refractory Gastro-esophageal Reflux Disease NCT03676374 | Universitaire Ziekenhuizen KU Leuven | Phase 4 |
| Unknown | A New System for GERD Diagnosis and Treatment NCT03600974 | Capital Medical University | — |
| Completed | How Reflux Medications Affect the Microbiome of Infants NCT03747991 | Nemours Children's Clinic | — |
| Completed | Effect of Obesity on Proton Pump Inhibitors NCT04248335 | Children's Mercy Hospital Kansas City | Phase 4 |
| Completed | A Study to Compare PK, PD and Safety of CKD-381 and D026 in Healthy Subjects NCT03558425 | Chong Kun Dang Pharmaceutical | Phase 1 |
| Completed | Utilization of Anti-reflux Treatment and Course of Illness Leading to Reoperation NCT03536169 | University of Southern Denmark | — |
| Unknown | Endomina Suturing Device as a Treatment of GERD. NCT03999502 | Erasme University Hospital | N/A |
| Unknown | Gluten Related Disorders in Barrett's Esophagus NCT03329534 | McMaster University | N/A |
| Completed | A Study to Compare PK and Safety of CKD-381 and D026 in Healthy Male Subjects NCT03444402 | Chong Kun Dang Pharmaceutical | Phase 1 |
| Withdrawn | Cardiac Safety of Lansoprazole and Domperidon Combination NCT03355170 | Neutec Ar-Ge San ve Tic A.Ş | Phase 4 |
| Completed | Applying Long-term Follow-up to Improve Patient Selection in Laparoscopic Anti-reflux Surgery NCT03959020 | University of Southern Denmark | — |
| Completed | Long-term Follow-up After OAGB NCT07125638 | Azienda Sanitaria Locale Napoli 2 Nord | — |
| Unknown | Novel Endoluminal Clinical TreAtment of Reflux NCT03090607 | Impleo Medical Inc. | N/A |
| Completed | The Evaluation of Patients With Esophageal and Foregut Disorders With WATS (Wide Area Transepithelial Sample W NCT03859557 | CDx Diagnostics | — |
| Completed | PK/PD Clinical Trial of YYD601 in Healthy Adult Male NCT03558477 | Yooyoung Pharmaceutical Co., Ltd. | Phase 1 |
| Completed | Efficacy and Safety Evaluation of Neobianacid® in GERD and EPS NCT03238534 | Aboca Spa Societa' Agricola | Phase 4 |
| Completed | A Study to Compare PK, PD and Safety of CKD-381 in Healthy Subjects NCT03211143 | Chong Kun Dang Pharmaceutical | Phase 1 |
| Completed | Complications, Outcomes and Revisions Following Hiatal Hernia Repair With MIROMESH NCT03735862 | Miromatrix Medical Inc. | — |
| Completed | Correlates of GERD Symptom Severity NCT03020550 | Massachusetts General Hospital | — |
| Suspended | Endoscopic Resection in Gastro-Esophageal Reflux Disease NCT03357809 | Hospital St. Joseph, Marseille, France | N/A |
| Completed | Understanding the Pathophysiology and Effects of Diaphragmatic Breathing in Upright Gastroesophageal Reflux NCT02972047 | Mayo Clinic | N/A |
| Completed | LINX Reflux Management System in Subjects With GERD Who Have Previously Undergone a Laparoscopic Sleeve Gastre NCT02429830 | Torax Medical Incorporated | N/A |
| Completed | An Open-Label Trial of Dexlansoprazole 60mg for the Relief of Heartburn During the Fasting Month of Ramadan NCT03079050 | American University of Beirut Medical Center | Phase 4 |
| Completed | Effects of Vented Base Feeding Bottle in Preterm Infants With GERD Symptoms. NCT03031288 | University of Turin, Italy | N/A |
| Completed | The Study of Nutrition of Children and Adolescents With GERD NCT04202276 | Federal State Budgetary Scientific Institution "Federal Research Centre of Nutrition, Biotechnology | N/A |
| Withdrawn | [Impedance Measurement for Non-Erosive Reflux Disease NCT02997527 | Mayo Clinic | N/A |
| Unknown | Evaluation of Safety and Effectiveness of the RefluxStop Device in the Management of GERD NCT02759094 | Implantica CE Reflux Ltd. | N/A |
| Completed | Influence of Central Obesity on the Esophageal Epithelial Barrier NCT02776982 | Mayo Clinic | N/A |
| Completed | Response Surface Pathway Design With Two Interventional- and One Response Variable in Estimating Minimum Effic NCT03568825 | Meddoc | N/A |
| Terminated | Management of Reflux After Sleeve Using Stretta NCT02637713 | Montefiore Medical Center | N/A |
| Unknown | the Efficency and Safety of Stretta in GERD NCT03574831 | Capital Medical University | — |
| Terminated | RELIEF Europe Study NCT02762487 | Torax Medical Incorporated | N/A |
| Unknown | Melanole, a Dietary Supplement, for the Treatment of Gastroesophageal Reflux Disease NCT02587910 | Lebanese American University | Phase 2 / Phase 3 |
| Completed | Minimal Injuries From Esophagus Detected by Optical Enhancement System™ Associated to Optical Magnification HD NCT02575287 | Instituto Ecuatoriano de Enfermedades Digestivas | — |
| Completed | Cytosponge Adequacy Study Evaluation II NCT02395471 | Medtronic - MITG | N/A |
| Unknown | Does Use of Topical Lidocaine in EGD Reduce Amount of IV Midazolam and Fentanyl Required and Shorten Recovery NCT02620501 | Brooke Army Medical Center | N/A |
| Completed | Image-Enhanced Endoscopy (IEE) for Diagnosis of Non-Erosive Reflux Disease NCT02629081 | Loren Laine | — |
| Terminated | Electrical Stimulation Therapy (EST) of the Lower Esophageal Sphincter (GERD) NCT02514616 | Erasme University Hospital | N/A |
| Unknown | STRETTA ,Radio Frequency Ablation (RFA) v/s Sham Therapy for the Treatment of Refractory GERD NCT02935881 | Asian Institute of Gastroenterology, India | Phase 3 |
| Unknown | The Relationship Between Gastroesophageal Reflux and Pediatric Rhinitis: Significance of Pale/Blue Colored Tur NCT02278081 | McGill University Health Centre/Research Institute of the McGill University Health Centre | Phase 4 |
| Unknown | Study of a Dietary Supplement for Reflux During Sleep NCT02274636 | Oral Care Research Associates, Seattle | N/A |
| Suspended | A Prospective Blinded Randomized Study Comparing Laparoscopic Sleeve Gastrectomy and Laparoscopic Roux-en-y Ga NCT02142998 | McMaster University | N/A |
| Completed | Can Quercetin Increase Claudin-4 and Improve Esophageal Barrier Function in GERD? NCT02226484 | University of North Carolina, Chapel Hill | Phase 1 |
| Unknown | An Investigation of Electrical Stimulation on Gastroesophageal Reflux Disease (GERD) in Patients After Sleeve NCT02210975 | Maastricht University Medical Center | N/A |
| Completed | High Definition Endoscopy With NBI. Contribution in Patients With Non-erosive Esophagitis NCT03824431 | University of Sao Paulo General Hospital | — |
| Terminated | Gastroesophageal Reflux Disease Prospective Registry NCT02479438 | Baylor Research Institute | — |
| Unknown | Research of Efficient Use of Omeprazole in Combination With Domperidone in Gastroesophageal Reflux Disease of NCT02140073 | Belarusian Medical Academy of Post-Graduate Education | Phase 4 |
| Recruiting | Mechanisms Preventing Pharyngeal Reflux NCT05696184 | Medical College of Wisconsin | N/A |
| Completed | Pharmacokinetics of Pantoprazole and CYP2C19 Activity in Children and Adolescents With GERD: A Pilot Study NCT01887743 | Children's Mercy Hospital Kansas City | Phase 1 |
| Completed | Study to Evaluate the Safety and Efficacy of CJ-12420 in Patients With Erosive Esophagitis NCT02028663 | HK inno.N Corporation | Phase 2 |
| Terminated | EndoStim Patient Registry NCT02441400 | EndoStim Inc. | — |
| Terminated | In Vivo Anatomy, Physiology, Mechanics and Function of the Lower Esophageal Sphincter NCT00737802 | Northwell Health | — |
| Recruiting | Compassionate Use of Domperidone for Refractory Gastroparesis NCT04699591 | Jose Cocjin | N/A |
| Completed | Efficacy and Saafety of Omez Iin Patients With H.Pylori Associated Diseases NCT02922699 | Dr. Reddy's Laboratories Limited | Phase 4 |
| Completed | A Study of the Effect of ONO-8539 on Oesophageal Pain Hypersensitivity in Patients With Non-erosive Reflux Dis NCT01707901 | Ono Pharmaceutical Co., Ltd. | Phase 1 |
| Completed | A Randomized Trial of Medical and Surgical Treatments for Patients With GERD Symptoms That Are Refractory to P NCT01265550 | VA Office of Research and Development | Phase 3 |
| Completed | Intraoperative Endomanometric Laparoscopic Nissen Fundoplication Improves Postoperative Outcomes NCT05851794 | Zagazig University | N/A |
| Completed | Esophageal Monitoring Device for Assessing Mucosal Impedance NCT01556919 | Vanderbilt University | — |
| Terminated | Self-Propelled Percutaneous Endoscopic GastroJejunostomy (PEG-J) NCT01551095 | Johns Hopkins University | Phase 2 |
| Completed | Pantoprazole Magnesium 40 mg Versus Esomeprazole 40 mg in Patients With Erosive Gastroesophageal Reflux Diseas NCT01132638 | Takeda | Phase 3 |
| Completed | To Assess the Efficacy of Esomeprazole 20mg Once Daily in Subjects Who Still Had Heartburn After Receiving Rab NCT01397084 | AstraZeneca | Phase 4 |
| Completed | Biology in Patients With Reflux Esophagitis NCT01194323 | Vanderbilt University Medical Center | — |
| Completed | Efficacy Study of Ilaprazole to Treat Erosive Esophgitis NCT01509261 | Il-Yang Pharm. Co., Ltd. | Phase 3 |
| Completed | Observational Study (This Means That no Drug is Tested) in Patients Suffering of Gastroesophageal Reflux Disea NCT01601379 | Janssen-Cilag International NV | — |
| Completed | An Epidemiological Study to Describe Symptom Control and Impact of Gastroesophageal Reflux Disease NCT01134367 | AstraZeneca | — |
| Withdrawn | Correlation of High Resolution Esophageal Manometry With Symptoms NCT01202929 | University of Louisville | — |
| Completed | Observational Study of Anti-Reflux Surgery NCT01624506 | Torax Medical Incorporated | — |
| Terminated | A Feasibility Study of Confocal Microendoscopy in the Evaluation of Gastrointestinal Neoplasia -Project 1 NCT01384695 | Anandasabapathy, Sharmila, M.D. | EARLY_Phase 1 |
| Terminated | Impact of Weight Loss on Gastroesophageal Reflux Disease in Overweight and Obese Subjects: a Prospective Study NCT01574573 | Midwest Biomedical Research Foundation | N/A |
| Completed | Structured Treatment of Gastroesophageal Reflux in a Company Health Care Setting, -Effect on Quality of Life, NCT00884247 | AstraZeneca | — |
| Withdrawn | Placebo Controlled Study of Baclofen for GERD in Children With Cerebral Palsy NCT01386255 | Boston Children's Hospital | Phase 4 |
| Terminated | Effect of Antireflux Therapy on the Expression of Genes in Patients With GERD NCT00624546 | University of Rochester | — |
| Completed | Twenty-Four Hour Combined Multi-Channel Impedance and pH Ambulatory Monitoring: Impedance Reflux Episodes of P NCT01710800 | Walter Reed National Military Medical Center | N/A |
| Terminated | Domperidone for Relief of Gastrointestinal Disorders NCT00761254 | Carle Physician Group | N/A |
| Completed | Gastroesophageal Reflux Disease (GERD)/Nighttime Heartburn and Driving Performance NCT01079884 | David A. Johnson, MD | N/A |
| Completed | The Role Of Gastroesophageal Reflux Disease (GERD) in Eosinophilic Esophagitis NCT00728481 | Mayo Clinic | Phase 2 / Phase 3 |
| Completed | Validation of Patient-reported Outcomes Measures for the Assessment of Gastroesophageal Reflux Disease (GERD) NCT00703534 | AstraZeneca | Phase 2 |
| Completed | A Pharmacokinetic and Safety Study of Single and Multiple Doses of Rabreprazole in Pediatric Patients With Gas NCT00747695 | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | Phase 1 |
| Completed | Gastroesophageal Reflux Disease (GERD) Segmentation: Document How Swiss General Practitioners (GPs) Allocate T NCT00688675 | AstraZeneca | — |
| Completed | Proton Pump Inhibitor (PPI) Therapy for Newly Diagnosed Esophagitis NCT00586963 | Mayo Clinic | — |
| Completed | Does Omeprazole Decrease Intestinal Calcium Absorption? NCT00582972 | University of Wisconsin, Madison | Phase 4 |
| Completed | Canadian, Multi-Centre Study of Symptom Burden and Clinical Management in Subjects With GERD NCT00634023 | AstraZeneca | — |
| Completed | National Survey on Gastroesophageal Reflux Disease (GERD) Patients NCT00695838 | AstraZeneca | — |
| Completed | Asociación Española de Gastroenterologia (Spanish Gastroenterology Association) Gastroesophageal Reflux Diseas NCT00697008 | AstraZeneca | — |
| Terminated | Study of Endoscopic Barrett's Esophagus Diagnosis NCT00591461 | Oregon Health and Science University | — |
| Active Not Recruiting | Minimally Invasive Surgery of the Gastro-esophageal Junction NCT01799967 | Ottawa Hospital Research Institute | — |
| Terminated | What is the Predictive Value of the Reflux Impact Scale NCT00536328 | AstraZeneca | — |
| Completed | Acid Reflux and Stromal Fibroblasts in Barrett's Esophagus NCT00573911 | Mayo Clinic | Phase 1 |
| Completed | LIFE NIS, GERD-Patients - Evaluation of Burden of Disease Determined by GERD Impact Scale (GIS) NCT00567619 | AstraZeneca | — |
| Completed | Barrett's Esophagus & Gastroesophageal Reflux Disease NCT00513331 | Valley Health System | — |
| Completed | Epidemiological Study to Assess the Symptoms and Patterns of Diagnosis and Treatment of GERD NCT00524355 | AstraZeneca | — |
| Completed | Nexium (Esomeprazole) in Symptom Adapted Therapy in GERD Patients NCT00444275 | AstraZeneca | Phase 4 |
| Completed | Electronic Health Record (EHR)-Based Intervention for Gastroesophageal Reflux Disease (GERD) and Chronic Non-s NCT00691171 | AstraZeneca | — |
| Completed | Efficacy and Safety of Esomeprazole Once Daily for the Treatment of GERD in Neonatal Patients NCT00427635 | AstraZeneca | Phase 3 |
| Completed | Efficacy of Dx-pH Probe in Diagnosing Extra-esophageal Reflux Disease NCT00388453 | Vanderbilt University Medical Center | N/A |
| Completed | Safety and Efficacy Study of Axid Use in Infants Suffering From Gastroesophageal Reflux Disease (GERD) NCT00373334 | Braintree Laboratories | Phase 3 |
| Completed | Symptom Assessment in Adult Patients With Erosive GERD (Gastroesophageal Reflux Disease) or enGERD (Endoscopic NCT00336219 | Takeda | Phase 3 |
| Completed | Impact of GERD on Daily Life (NIS) NCT00545883 | AstraZeneca | — |
| Completed | Effect of Coffee on Gastro-Esophageal Disease in Patients With Symptoms of Reflux NCT00584259 | University of California, Davis | N/A |
| Completed | to Assess the Efficacy and Safety of the Probiotic E. Coli Strain M17 on Patients With GERD NCT00324532 | BioBalance Corporation | Phase 3 |
| Terminated | Multi-Center Study of the NDO Surgical Plicator Utilizing Multiple Implants for the Treatment of GERD NCT00586859 | NDO Surgical, Inc. | N/A |
| Completed | Nexium RESPONSE Trial NCT00318968 | AstraZeneca | Phase 4 |
| Terminated | Study of Cryotherapy Treatment of Barrett's Esophagus and Early Esophageal Cancer NCT00321958 | University of Maryland, Baltimore | — |
| Completed | Safety and Efficacy Study to Determine Anti-Asthmatic Effect of Esomeprazole Magnesium; Nexium Reflux Asthma NCT00317044 | AstraZeneca | Phase 2 |
| Completed | A Comparative Study of Proton-pump Inhibitor Tests for Chinese Reflux Patients in Relation to the CYP2C19 Geno NCT00681005 | National Taiwan University Hospital | N/A |
| Completed | An Open-Label Study of Once-Daily Oral Administration of Esomeprazole 40 mg in Patients With Symptoms of Gastr NCT00242736 | AstraZeneca | Phase 4 |
| Completed | A Study to Monitor Intragastric pH in Patients Taking Rabeprazole vs. Patients Taking Pantoprazole NCT00378287 | Janssen-Ortho Inc., Canada | Phase 1 |
| Completed | A Study to Evaluate the Efficacy and Safety of Controlled Release Arbaclofen Placarbil (XP19986) in Patients W NCT00838396 | Indivior Inc. | Phase 2 |
| Completed | Nexium 40mg Once Daily vs Prevacid 30mg Twice a Day for Control of Severe GERD NCT00295685 | Digestive & Liver Disease Specialists | Phase 4 |
| Completed | The Utility of Nexium in Chronic Cough and Reflux Disease NCT00287339 | University of North Carolina, Chapel Hill | Phase 4 |
| Completed | Determination of a Questionnaire After Treatment With Pantoprazole at Full Dose and Half Dose in Adult Patient NCT00261339 | Takeda | Phase 4 |
| Completed | CYP2C19 Genetic Polymorphism on the Accuracy of Proton-Pump Inhibitor Testing NCT00354757 | National Taiwan University Hospital | Phase 4 |
| Completed | Conventional Nissen Fundoplication Versus Laparoscopic Nissen Fundoplication NCT01230944 | Turku University Hospital | N/A |
| Completed | Sleep Disorders and Gastroesophageal Reflux Disease (GERD) NCT00287391 | University of North Carolina | Phase 4 |
| Terminated | Registry Study of the NDO Surgical Plicator for the Treatment of GERD NCT00597792 | NDO Surgical, Inc. | N/A |
| Completed | The Effect of Lifestyle-Adjustments Prior to Medical Treatment on the Effect of Medical Treatment in Reflux Pa NCT00524251 | AstraZeneca | — |
| Unknown | On-Demand Use of Pantoprazole: Determinants for Chronic Use of Acid Suppressive Medication NCT00161096 | UMC Utrecht | Phase 3 |
| Withdrawn | PPI Versus Placebo in Severe Functional Heartburn NCT00222989 | University of Southern California | N/A |
| Completed | PPI Test in GP Patients NCT00318084 | AstraZeneca | Phase 4 |
| Completed | Comparison of Laparoscopic Hill and Laparoscopic Nissen Anti-Reflux Procedures NCT01260935 | Swedish Medical Center | N/A |
| Completed | An Open, Randomized, Two Way Crossover Study Comparing the Effect of 20mg Esomeprazole Administered Orally and NCT00629564 | AstraZeneca | Phase 4 |
| Completed | Open, Randomized, Two Way Crossover 40mg, Orally and Intravenously NCT00635414 | AstraZeneca | Phase 4 |
| Completed | Study of the NDO Endoscopic Plication System For the Treatment of Symptomatic Gastroesophageal Reflux Disease NCT00587522 | NDO Surgical, Inc. | N/A |
| Completed | Esomeprazole for Prevention of Upper Gastrointestinal Symptoms Associated With Continuous Use of NSAIDs NCT00241514 | AstraZeneca | Phase 3 |
| Completed | Esomeprazole for Relief of Upper Gastrointestinal Symptoms Associated With Continuous Use of NSAIDs NCT00241540 | AstraZeneca | Phase 3 |
| Completed | Sopran - Omeprazole Treatment Versus Surgery NCT00256737 | AstraZeneca | Phase 3 |
| Completed | Surgery in Chronic Cough GERD Related NCT01899183 | University of Bologna | — |
| Terminated | Gatekeeper European 005 NCT00229086 | MedtronicNeuro | — |
| No Longer Available | Treatment Use of Domperidone for Gastroparesis NCT02227927 | Scott Gabbard, MD | — |