NCT00582972

Does Omeprazole Decrease Intestinal Calcium Absorption?

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 23 (actual)
• Sponsor: University of Wisconsin, Madison · Academic / Other
• Sex: Female
• Age: —
• Healthy volunteers: Accepted

Summary

The purpose of this study is to measure the effect of omeprazole on intestinal calcium absorption in postmenopausal women.

Detailed description

Existing literature makes it unclear whether proton pump inhibitor therapy truly decreases intestinal calcium absorption. Up to 25 postmenopausal women will participate in this study. The primary study outcome is the change in intestinal calcium absorption following omeprazole therapy 40 mg daily for 30 days. The secondary outcomes include the change in urine n-telopeptide. We will interview women and review their medical records to determine eligibility. Eligible subjects will undergo three calcium absorption studies. The first 2 studies will determine the monthly variation in calcium absorption, while the 3rd study will occur after taking 40 mg of omeprazole daily for 30 days. Women will present to the research unit in the early morning and receive an oral and intravenous calcium tracer with breakfast. Over the next 24 hours, we will collect all urine for measurement of its calcium content. During the first stay, we will measure each subject's gastric pH by collecting gastric fluid from a temporary nasogastric tube. In consenting subjects we will collect one tube of blood, isolate its DNA.

Conditions

• Osteoporosis
• Achlorhydria
• GERD
• Hip Fracture

Interventions

Type	Name	Description
DRUG	Omeprazole	40 mg po qAM one-half hour before breakfast for 30 days

Timeline

• Start date: 2008-01-01
• Primary completion: 2008-12-01
• Completion: 2010-12-01
• First posted: 2007-12-28
• Last updated: 2013-02-15
• Results posted: 2013-01-21

Locations

1 site across 1 country: United States