Trials / Completed
CompletedNCT00681005
A Comparative Study of Proton-pump Inhibitor Tests for Chinese Reflux Patients in Relation to the CYP2C19 Genotypes
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 178 (actual)
- Sponsor
- National Taiwan University Hospital · Academic / Other
- Sex
- All
- Age
- —
- Healthy volunteers
- Not accepted
Summary
Backgrounds \& Aims: Proton-pump inhibitor (PPI) test has been proposed as a valuable tool in the diagnosis of gastroesophageal reflux disease (GERD) in Western populations. We assumed that a higher prevalence of poor metabolizers in Chinese population might affect the diagnostic accuracy of a PPI test. Methods: In this open-label, randomized trial, patients with symptoms suggestive of GERD were randomly assigned to receive a 2-week test with daily rabeprazole 40-mg or daily pantoprazole 80-mg after diagnostic endoscopy. Therapeutic response was assessed with a five-grade daily record. Genotypes of cytochrome P450 (CYP) 2C19 polymorphism were determined.
Detailed description
As described above
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | rabeprazole | 20 mg bid for 14 days |
| DRUG | pantoprazole | pantoprazole 40 mg bid |
Timeline
- Start date
- 2006-04-01
- Primary completion
- 2008-01-01
- Completion
- 2008-01-01
- First posted
- 2008-05-20
- Last updated
- 2013-12-11
Source: ClinicalTrials.gov record NCT00681005. Inclusion in this directory is not an endorsement.