| Not Yet Recruiting | Describing the Effect of Familiar Song on Arousal and Awareness for Children With Disorders of Consciousness ( NCT07209657 | Murdoch Childrens Research Institute | N/A |
| Not Yet Recruiting | Auditory Processing in DOC Patients NCT07455682 | BDH-Klinik Hessisch Oldendorf | — |
| Not Yet Recruiting | Neurorehabilitation in Patients With Disorders of Consciousness: Multidimensional Ambispective Study on the Im NCT07385508 | IRCCS Centro Neurolesi Bonino Pulejo | — |
| Not Yet Recruiting | Alpha tACS for Disorders of Consciousness : a Single Case Experimental Design NCT07213869 | Hospices Civils de Lyon | N/A |
| Not Yet Recruiting | Vagal Nerve Stimulation to Treat Disorders of Consciousness NCT07077135 | Fondazione IRCCS San Gerardo dei Tintori | N/A |
| Recruiting | Study on the Effectiveness and Safety of Temporal Interference Stimulation in Treating Patients With Severe Co NCT06896279 | Huashan Hospital | N/A |
| Recruiting | Efficacy and Safety of Spinal Cord Stimulation in Patients With Spinal Cord Stimulation NCT06515132 | Huashan Hospital | N/A |
| Not Yet Recruiting | Combined Whole-brain Structural and Functional MRI for the Prediction of Neurological Recovery After Cardiac A NCT06617377 | University Hospital, Toulouse | N/A |
| Recruiting | Robotic vs. Traditional Verticalization in Patients With Severe Acquired Brain Injury: a Randomized Controlled NCT06469983 | Anna Estraneo | N/A |
| Recruiting | Effects of rTMS With Different Stimulation Spots in Patients With Disorders of Consciousness NCT06527573 | Zhujiang Hospital | N/A |
| Unknown | rTMS and EEG in DOC Patients NCT04401319 | University of Liege | N/A |
| Recruiting | Improving the Diagnostic Accuracy of Children with DoC (IDeAl DesiRE) NCT06635291 | IRCCS Eugenio Medea | — |
| Recruiting | Emotional and Neutral Sounds for Neurophysiological Prognostic Assessment of Critically Ill Patients With a Di NCT05740735 | Assistance Publique - Hôpitaux de Paris | — |
| Withdrawn | Safety and Efficacy of tDCS in Pediatric DoC NCT05929274 | Giovanna Cristella | N/A |
| Recruiting | Electro-acupuncture to Treat Disorder of Consciousness NCT06268236 | The Second Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine | N/A |
| Unknown | Five-day 20-minute 10-Hz tACS in Patients With a Disorder of Consciousness NCT05833568 | Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal | N/A |
| Unknown | Efficacy and Safety of Cerebrolysin on Prolonged Disorders of Consciousness NCT04427241 | Konkuk University Medical Center | Phase 4 |
| Unknown | tDCS and rTMS in Patients With Early Disorders of Consciousness NCT05820178 | Xuanwu Hospital, Beijing | N/A |
| Enrolling By Invitation | Prognostication of Recovery in Early Disorders of Consciousness Study NCT07074678 | University of Pennsylvania | N/A |
| Unknown | Amantadine for Neuroenhancement in Acute Patients Study NCT05479032 | University Hospital Tuebingen | Phase 2 |
| Unknown | Hydrocephalus Treatment on Persistent Disorder of Consciousness NCT05219331 | University Hospital, Toulouse | N/A |
| Recruiting | Music Intervention and Transcranial Electrical Stimulation for Neurological Diseases NCT05706831 | Istituti Clinici Scientifici Maugeri SpA | N/A |
| Unknown | Personal Music for Disorders of Consciousness NCT05382260 | Qiuyou Xie | N/A |
| Recruiting | Ketamine to Treat Patients With Post-comatose Disorders of Consciousness NCT05343507 | University of Liege | Phase 2 / Phase 3 |
| Completed | Eye Tracking Technology in the Diagnosis of Neurological Patients NCT05536921 | AssisTech Sp. z o.o. | — |
| Unknown | Cerebellar iTBS in Patients With Disorders of Consciousness NCT05558930 | Xijing Hospital | N/A |
| Enrolling By Invitation | Study of Brain Function Evaluation and Intervention System for Acute and Prolonged Disorders of Consciousness NCT05682248 | Xuanwu Hospital, Beijing | N/A |
| Enrolling By Invitation | Study of Brain Function Evaluation System for Acute and Prolonged Disorders of Consciousness NCT06097013 | Xuanwu Hospital, Beijing | — |
| Unknown | Prediction Model of Improvement of Disturbance of Consciousness in Patients With Hydrocephalus After Shunt Ope NCT05237102 | Zhuohang Wang | N/A |
| Completed | Effectiveness of Sensory Stimulation on Attenuating Pain and Stress Among Patients With Disorders of Conscious NCT05308186 | Tel Aviv University | N/A |
| Recruiting | Evaluation of the MuSICCA for Measuring Awareness NCT04050995 | The Children's Trust, United Kingdom | — |
| Recruiting | Awareness Detection and Communication in Disorders of Consciousness NCT03827187 | University of Ulster | N/A |
| Recruiting | An Ethical Approach to Detecting Covert Consciousness NCT05010265 | Massachusetts General Hospital | — |
| Completed | Multisensorial IMmersive Experiences (MIME) in Disorders of Consciousness NCT05734183 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | N/A |
| Unknown | SECONDs' Italian Translation and Transcultural Validation NCT05714215 | Fondazione Don Carlo Gnocchi Onlus | — |
| Completed | Olfactory Stimulation in Severe Brain Injury NCT05747170 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | N/A |
| Recruiting | Effects of Individualized rTMS in DOC Patients NCT05187000 | Qiuyou Xie | N/A |
| Recruiting | HD-tDCS Combined With Circadian Rhythm Reconstruction and Micro Expression Changes on Consciousness Recovery i NCT05285124 | First Affiliated Hospital of Zhejiang University | N/A |
| Completed | The Use of LIFUP in Chronic Disorders of Consciousness NCT04921683 | Casa Colina Hospital and Centers for Healthcare | N/A |
| Recruiting | Apomorphine in Severe Brain-injured Patients NCT05213169 | University of Liege | Phase 2 / Phase 3 |
| Unknown | Verticalization Robotic Exoskeleton DoC NCT04833543 | Memorial Hermann Health System | N/A |
| Unknown | Gamma Entrainment Improve the Recovery of Awareness NCT05640544 | Xijing Hospital | N/A |
| Suspended | Changes in Glutamatergic Neurotransmission of Severe TBI Patients NCT04244058 | Weill Medical College of Cornell University | EARLY_Phase 1 |
| Recruiting | Effectiveness of Music Therapy on Level of Consciousness NCT04442971 | BDH-Klinik Hessisch Oldendorf | N/A |
| Recruiting | Prognostic Factors to Regain Consciousness NCT04445649 | BDH-Klinik Hessisch Oldendorf | — |
| Unknown | Predictors of Better Outcomes After Severe Acquired Brain Injuries NCT04495192 | Fondazione Don Carlo Gnocchi Onlus | — |
| Unknown | Development of a Point of Care System for Automated Coma Prognosis NCT03826407 | McMaster University | — |
| Unknown | Pain Protocol: Nociception Coma Scale-Revised With Personalized Stimulus NCT06012357 | I.R.C.C.S. Fondazione Santa Lucia | — |
| Unknown | Spinal Cord Stimulation in Patients With Disorders of Consciousness NCT04010838 | Huashan Hospital | N/A |
| Unknown | SeeMe: An Automated Tool to Detect Early Recovery After Brain Injury NCT06083441 | Stony Brook University | — |
| Completed | Transcranial Direct Current Stimulation in Patients With Disorders of Consciousness NCT03809936 | First Affiliated Hospital of Zhejiang University | N/A |
| Unknown | Light Therapy in Disorders of Consciousness: Behavioral, Neuroimaging and (Neuro)Physiological Assessments. NCT03174119 | University of Liege | N/A |
| Terminated | CONsciousness Transcranial Electric STimulation NCT03576248 | Institut National de la Santé Et de la Recherche Médicale, France | N/A |
| Unknown | Treating Severe Brain-injured Patients With Apomorphine NCT03623828 | University of Liege | Phase 2 |
| Completed | Validity and Feasibility of the CRSR-FAST NCT03549572 | Massachusetts General Hospital | — |
| Completed | Metabolic Abnormalities and Intestinal Microecology in Patients With Chronic Disorders of Consciousness NCT04530968 | First Affiliated Hospital of Zhejiang University | — |
| Completed | Simultaneously PET/MRI in Prolonged DOC Patients NCT04164680 | Hangzhou Normal University | — |
| Completed | Prefontal tDCS in Patients With Disorders of Consciousness: Neurophysiological and Behavioural Outcomes NCT03823508 | University of Liege | N/A |
| Completed | A Promising Tool for Predicting Consciousness Evolution in Prolonged Disorders of Consciousness NCT02948660 | Xijing Hospital | Phase 2 |
| Completed | Long-term Effect of tDCS in Patients With Disorders of Consciousness NCT03114397 | University of Liege | N/A |
| Completed | Target Behaviours to Identify Minimally Conscious State Patients NCT04471753 | Hangzhou Normal University | — |
| Completed | Behavioral Assessment of Nociception on NCS-R NCT04137497 | Hangzhou Normal University | — |
| Completed | Diagnostic Accuracy of the Vegetative and Minimally Conscious State NCT04139239 | Hangzhou Normal University | — |
| Completed | Long Term Effects of Soft Splints on Stroke Patients and Patients With Disorders of Consciousness NCT03008486 | Géraldine Martens | Phase 2 |
| Unknown | Two Intensities of Transcranial Direct Current Stimulation to Improve Consciousness in Severely Brain Injured NCT03007784 | Groupe Hospitalier Pitie-Salpetriere | Phase 3 |
| Completed | Effects of Animal Assisted Therapy on Patients With Severe Disorders of Consciousness NCT02629302 | Swiss Tropical & Public Health Institute | N/A |
| Unknown | Proteomics for Chronic Disorder of Consciousness NCT03611166 | First Affiliated Hospital of Zhejiang University | — |
| Completed | Sub-study of the NEURODOC Project : Neurophysiological Evaluation of a Routine Care Open Label tDCS Session NCT04035655 | Groupe Hospitalier Pitie-Salpetriere | N/A |
| Completed | Effects of Different Stimuli in Patients With Disorders of Consciousness NCT03385291 | First Affiliated Hospital of Zhejiang University | N/A |
| Unknown | Transcranial Magnetic Stimulation in Patients With Disorders of Consciousness NCT03385278 | First Affiliated Hospital of Zhejiang University | N/A |
| Completed | Functional Connectivity Measurement After Severe Traumatic Brain Injury NCT02647996 | University Hospital, Grenoble | — |
| Completed | Effects of Emotional Stimuli in Patients With Disorders of Consciousness NCT03502837 | First Affiliated Hospital of Zhejiang University | — |
| Completed | Peripheral Inflammation and Brain Structural Alterations in Patients With Disorders of Consciousness. NCT03908541 | First Affiliated Hospital of Zhejiang University | — |
| Completed | Excitatory Prefrontal Weak Current Stimulation in Vegetative Patients NCT04614792 | Oded Meiron | N/A |
| Completed | Multichannel tDCS to Reduce Hypertonia in Patients With Prolonged DOC NCT03797573 | University of Liege | Phase 1 |
| Completed | Clinical Validity of the Minimally Conscious State "Plus" and "Minus" NCT05954650 | Hospitales Nisa | — |
| Completed | Information of the Coma Recovery Scale-Revised for Neurobehavioral State and Recovery of Consciousness Predict NCT05819177 | Hospitales Nisa | — |