NCT02647996

Functional Connectivity Measurement After Severe Traumatic Brain Injury

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 34 (actual)
• Sponsor: University Hospital, Grenoble · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

To compare functional connectivity after severe traumatic brain injury (TBI) between a group of post-comatose TBI with restored consciousness and a group of post-comatose TBI with persistant disorder of consciousness at admission in rehabilitation

Detailed description

Recovery of consciousness can be impaired in severe traumatic brain injury (TBI). Prognostic factors are sparse and mostly clinical (mainly the initial Glasgow coma scale GCS) (1). Functional magnetic resonance imaging (fMRI) could allow a better understanding of functional recovery. Graph method has been applied to fMRI signal analysis in disorder of consciousness (DOC) due to post-anoxic encephalopathy. Comatose state was characterized by dramatic change in local connectivity (hub location) without significant change in global connectivity (2). The present study aims at describing functional connectivity in DOC following severe TBI. We will record resting state fMRI in TBI patients in two clinical conditions: conscious state versus DOC state.

Conditions

• Disorder of Consciousness

Interventions

Type	Name	Description
PROCEDURE	MRI: functional (resting state) and structural (DTI)	One hour brain MRI recording without active task for the patient, no sedation

Timeline

• Start date: 2015-03-01
• Primary completion: 2018-07-01
• Completion: 2019-10-01
• First posted: 2016-01-06
• Last updated: 2020-03-20

Locations

1 site across 1 country: France