NCT04137497

Behavioral Assessment of Nociception on NCS-R

Behavioral Assessment of Nociception on the Nociception Coma Scale-Revised in Patients With Disorders of Consciousness: A Sign of Consciousness

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 140 (actual)
• Sponsor: Hangzhou Normal University · Academic / Other
• Sex: All
• Age: 20 Years – 84 Years
• Healthy volunteers: Not accepted

Summary

The aim of this study was to investigate the relationship between behaviorally assessed consciousness levels and responsiveness to nociception in patients with disorders of consciousness (DOC)

Detailed description

Patients with a clinical consensus of DOC were enrolled. The Coma Recovery Scale-Revised (CRS-R) was used to assess the DOC patients' consciousness levels and the Nociception Coma Scale-Revised (NCS-R) was used to evaluate their pain response over one week. Furthermore, the relationship between behaviorally assessed consciousness levels and pain response was analyzed.

Conditions

• Disorder of Consciousness
• Unresponsive Wakefulness Syndrome
• Minimally Conscious State

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	The Coma Recovery Scale-Revised and the Nociception Coma Scale-Revised (NCS-R)	All enrolled DOC patients were evaluated at least five times over one week by two trained professionals using the Chinese version of the CRS-R. During the evaluation of the patient's consciousness level, the NCS-R was used to evaluate the pain response of all patients in random order at least once, and the best behavioral response (i.e., the highest score) of each subscale was recorded during resting, noxious, and physiotherapy conditions, respectively, according to the NCS-R guidelines.

Timeline

• Start date: 2017-08-01
• Primary completion: 2019-05-25
• Completion: 2019-05-26
• First posted: 2019-10-24
• Last updated: 2019-11-14

Locations

1 site across 1 country: China