| Not Yet Recruiting | Nebulized Nasal Steroids NCT07270302 | Washington University School of Medicine | Phase 1 / Phase 2 |
| Not Yet Recruiting | Efficacy Of Erythromycin Phonophoresis on Chronic Rhinosinusitis NCT07063082 | Cairo University | N/A |
| Not Yet Recruiting | The Effect of Modified Olfactory Training on Postoperative Olfactory Dysfunction in Patients With CRS NCT06837051 | Peking University Third Hospital | N/A |
| Active Not Recruiting | Effects of Esketamine Versus Magnesium Sulfate on Emotional State and Postoperative Pain in Patients Undergoin NCT06920576 | The Second People's Hospital of Huai'an | Phase 1 / Phase 2 |
| Completed | Sleep Disturbance and Daytime Fatigue as Predictors of Cognitive Decline and Functional Decline in Chronic Rhi NCT07242040 | Sinai University | — |
| Recruiting | Long-term Safety and Efficacy of TQH2722 Injection in the Treatment of Chronic Sinusitis With or Without Nasal NCT06439381 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Phase 2 |
| Active Not Recruiting | Esmolol Versus Lidocaine on the Quality of Postoperative Recovery in Patients Undergoing Functional Endoscopic NCT06457100 | The Second People's Hospital of Huai'an | Phase 1 / Phase 2 |
| Unknown | Adjunctive Treatment for Chronic Rhinosinusitis With Nasal Polyposis NCT03607175 | Marina Boruk | Phase 2 / Phase 3 |
| Recruiting | Effect of Chinese Herbal Medicine Nasal Irrigation on the Postoperative Care of Chronic Rhinosinusitis NCT07340411 | Taichung Veterans General Hospital | Phase 2 |
| Active Not Recruiting | Paclitaxel-Coated Nasal Balloon for the Treatment of Recurrent Chronic Rhinosinusitis With or Without Nasal Po NCT05883462 | Airiver Medical, Inc. | EARLY_Phase 1 |
| Completed | Nigella Sativa for Selected Outcomes in Chronic Rhinosinusitis NCT05494164 | Cairo University | N/A |
| Completed | Microcurrent Device (TIVIC Health) NCT05198518 | Icahn School of Medicine at Mount Sinai | N/A |
| Terminated | Comparison of Chitodex Gel Vs NexFoam on Post-operative Outcomes in the Treatment of Chronic Rhinosinusitis NCT05083741 | St. Louis University | — |
| Recruiting | Rhinosinusitis Italian Network: the Italian Registry for Severe, Uncontrolled Chronic Rhinosinusitis NCT05935683 | Italian Academy of Rhinology | — |
| Completed | Povidone-Iodine Nasal Irrigation After Surgery for Chronic Rhinosinusitis NCT07470242 | Pusan National University Hospital | N/A |
| Completed | Self-assessment of Olfactory Disorders for French Speaking Patients NCT04705805 | University Hospital, Strasbourg, France | — |
| Completed | Validity of the French Version of the Child's Chronic Rhinosinusitis Questionnaire NCT04117646 | Assistance Publique - Hôpitaux de Paris | — |
| Completed | Efficacy and Safety of Xylitol Nasal Irrigation After Functional Endoscopic Sinus Surgery NCT06108921 | Taichung Veterans General Hospital | N/A |
| Completed | NAC Inhalation in the Treatment Of Symptomatic acuTe rhinosinUSitis NCT04131686 | Boryung Pharmaceutical Co., Ltd | — |
| Completed | Study Evaluating the Efficacy and Safety of Intranasal Administration of OPN-375 in Subjects With Chronic Rhin NCT03960580 | Optinose US Inc. | Phase 3 |
| Completed | Etokimab in Adults With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) NCT03614923 | AnaptysBio, Inc. | Phase 2 |
| Completed | Study Evaluating the Efficacy and Safety of Intranasal Administration of OPN-375 in Subjects With Chronic Rhin NCT03781804 | Optinose US Inc. | Phase 3 |
| Completed | An Extension Study of Omalizumab in Participants With Chronic Rhinosinusitis With Nasal Polyps NCT03478930 | Hoffmann-La Roche | Phase 3 |
| Completed | Xylitol for Chronic Sinusitis NCT03229551 | Ochsner Health System | Phase 2 / Phase 3 |
| Completed | A Clinical Trial of Omalizumab in Participants With Chronic Rhinosinusitus With Nasal Polyps NCT03280537 | Hoffmann-La Roche | Phase 3 |
| Completed | A Clinical Trial of Omalizumab in Participants With Chronic Rhinosinusitis With Nasal Polyps NCT03280550 | Hoffmann-La Roche | Phase 3 |
| Completed | Analysis of Inflammation and Microbiome in Patients With Sinusitis and Asthma NCT02548598 | University of California, San Francisco | — |
| Completed | Validation of the Chinese Version of the Sinus and Nasal Quality of Life Survey (SN-5) NCT04836403 | China Medical University Hospital | — |
| Unknown | Determinants of Olfactory Dysfunction in Chronic Rhinosinusitis NCT02720653 | Oregon Health and Science University | — |
| Completed | Sinupret Extract Coated Tablets in Chronic Rhinosinusitis NCT02746042 | Bionorica SE | Phase 3 |
| Completed | Large Scale Cerebral Oximetry During Sinus Endoscopy NCT02692794 | Icahn School of Medicine at Mount Sinai | — |
| Completed | Perioperative Oral Steroids for Chronic Rhinosinusitis Without Polyps (CRSsNP) NCT02748070 | Stanford University | N/A |
| Unknown | Prednisone in Chronic Rhinosinusitis Without Nasal Polyps NCT02367118 | University of Chile | Phase 3 |
| Completed | Early Saline Irrigation to Decrease Post-operative Endoscopic Debridement NCT01943370 | University of Alberta | N/A |
| Completed | Mitomicin C for Prevention Postoperative Endoscopic Sinus Surgery Synechia and QOL in Chronic Rhinosinusitis NCT02106793 | Mahidol University | Phase 3 |
| Unknown | Efficacy of Nasal Irrigation With Respimer® Netiflow® vs Saline Among Patients With Cystic Fibrosis and Chroni NCT03145051 | Laboratoire de la Mer | N/A |
| Terminated | Global Sinus Surgery Registry NCT02347943 | Integra LifeSciences Corporation | — |
| Completed | NuVent™ Revision Study NCT02284347 | Medtronic Surgical Technologies | N/A |
| Completed | Azithromycin for Patients With Chronic Rhinosinusitis Failing Medical and Surgical Therapy NCT02307825 | Centre hospitalier de l'Université de Montréal (CHUM) | Phase 4 |
| Terminated | Itraconazole for Fungal Sensitive Chronic Rhinosinusitis With Nasal Polyps NCT02285283 | The University of Texas Health Science Center, Houston | Phase 2 / Phase 3 |
| Completed | A Randomized Controlled Trial Evaluating Postoperative Debridement Following Endoscopic Sinus Surgery NCT02154555 | Unity Health Toronto | N/A |
| Completed | Efficacy of Macrolide and Glucocorticoid in the Treatment of Chronic Rhinosinusitis After Endoscopic Sinus Sur NCT02182492 | Zheng Liu | N/A |
| Completed | Oral Versus Topical Antibiotics for Chronic Rhinosinusitis Exacerbations NCT01988779 | University of Rochester | Phase 3 |
| Completed | Effect of Dietary Salicylate in Aspirin Exacerbated Respiratory Disease NCT01778465 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | N/A |
| Completed | Safety and Efficacy of Lactococcus Lactis Probiotic Bacteria for the Treatment of Chronic Rhinosinusitis NCT04048174 | Centre hospitalier de l'Université de Montréal (CHUM) | N/A |
| Completed | Saline Irrigation After Surgery in Patients With Chronic Sinusitis NCT01575223 | Samuel Lunenfeld Research Institute, Mount Sinai Hospital | Phase 4 |
| Terminated | Canadian Health Economics, Outcome, and Effectiveness Comparison of Treatment in Patients With Chronic Rhinosi NCT01455948 | Integra LifeSciences Corporation | N/A |
| Completed | Surgery Checklist and Process Improvement Surrounding Endoscopic Sinus Surgery NCT01499719 | Oregon Health and Science University | — |
| Completed | Influence of Oral Doxycycline on Wound Healing After Endonasal Endoscopic Sinus Surgery for Chronic Rhinosinus NCT01198912 | University Hospital, Ghent | Phase 2 |
| Completed | The Use of Antibiotic Sinonasal Rinse After Sinus Surgery NCT02218307 | University of Miami | Phase 4 |
| Completed | Budesonide Application Via Mucosal Atomization Device as a Treatment for Chronic Rhinosinusitis When Utilized NCT01405339 | St. Paul's Hospital, Canada | Phase 1 / Phase 2 |
| Completed | Response Shift in Sinus Surgery Outcomes NCT01391910 | Greg Davis | — |
| Completed | Determinants of Medical and Surgical Treatment Outcomes in Chronic Sinusitis NCT01332136 | Oregon Health and Science University | — |
| Withdrawn | Oral Steroid Treatment for Chronic Rhinosinusitis NCT01255683 | Oregon Health and Science University | — |
| Terminated | Impact of Topical Sinonasal Budesonide Irrigation on Hypothalamic-Pituitary-Adrenal Axis Function NCT01373528 | Ottawa Hospital Research Institute | N/A |
| Terminated | Total Intravenous Anesthesia (TIVA) vs. Inhaled Anesthesia for Endoscopic Sinus Surgery. NCT01214057 | The University of Texas Health Science Center, Houston | N/A |
| Completed | Chronic Rhinosinusitis in a Danish Population: Evaluation of Causes of Disease, Progress and Treatment NCT01402349 | Odense University Hospital | — |
| Unknown | Chronic Rhinosinusitis: Biochemical Markers and Biofilm NCT01084811 | University Hospital, Akershus | — |
| Completed | Subcutaneous Omalizumab for Treatment of Chronic Rhinosinusitis With Nasal Polyposis NCT01066104 | Massachusetts General Hospital | Phase 2 |
| Unknown | Effect of Sinufoam-Dexamethasone Mixture on Post Endoscopic Sinus Surgery Outcomes NCT01024075 | University of Calgary | Phase 4 |
| Completed | Effect of Prednisone onTregs and TH17 NCT01002313 | University of Chicago | — |
| Completed | Medical Therapy Versus Sinus Surgery for Chronic Rhinosinusitis: A Prospective, Multi-institutional Study NCT01255566 | Oregon Health and Science University | — |
| Completed | Mucociliary Clearance Time in Chronic Rhinosinusitis (CRS) Patients After Sinus Surgery NCT00947986 | The University of Texas Health Science Center, Houston | N/A |
| Completed | Point-of-Care Computed Tomography (CT) Chronic Rhinosinusitis Study NCT00871286 | Northwestern University | N/A |
| Unknown | Computed Tomography (CT) Score and Histopathology of the Middle Turbinate in Chronic Rhinosinusitis NCT00899561 | Meir Medical Center | — |
| Completed | The Sinonasal Outcome Test - 22, Validated for Danish Patients NCT01254916 | Odense University Hospital | — |
| Completed | Systemic Methylprednisolone in Chronic Rhinosinusitis NCT01205984 | Ondokuz Mayıs University | Phase 4 |
| Completed | Use of Probiotics as Adjunctive Treatment for Chronic Rhinosinusitis NCT00396162 | University of Michigan | Phase 4 |
| Completed | Study of Nasal Irrigation Versus Nasal Spray for Chronic Nasal and Sinus Symptoms NCT00318006 | University of Michigan | Phase 4 |
| Completed | Nasal Inhalation of Dornase Alfa (Pulmozyme) in Patients With Cystic Fibrosis and Chronic Rhinosinusitis NCT00265434 | University of Jena | Phase 3 |
| Completed | Determinants of Surgical Outcomes in Chronic Sinusitis NCT00799097 | Oregon Health and Science University | — |
| Completed | Pathogenesis of Chronic Sinusitis in Relationship to Tobacco Smoke Exposure NCT01179139 | Massachusetts General Hospital | N/A |
| Completed | Microarray Analysis of Sinus Samples From Patients With and Without Chronic Rhinosinusitis. NCT00847041 | University of California, San Francisco | — |