NCT01778465

Effect of Dietary Salicylate in Aspirin Exacerbated Respiratory Disease

Effect of Low Dietary Salicylate on Biochemical Markers of Aspirin Exacerbated Respiratory Disease

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 7 (actual)
• Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · Academic / Other
• Sex: All
• Age: 18 Years – 100 Years
• Healthy volunteers: Not accepted

Summary

Aspirin-Exacerbated Respiratory Disease, or AERD, consists of aspirin sensitivity, asthma and nasal polyps. It is currently managed by chronic steroid use, multiple endoscopic sinus surgeries and/or aspirin desensitization. However, these treatments have potential adverse effects. A theory has been postulated that decreasing the level of dietary salicylates may help in long-term control of disease. A current trial is in the works to evaluate the clinical outcomes of decreased salicylate, but measurements of biochemical markers of disease has not yet been done. The hypothesis is that decreased dietary salicylates will result in a decrease in urinary salicylates and inflammatory markers of disease, cys-leukotrienes, which are typically elevated in this disease.

Conditions

• Chronic Rhinosinusitis
• Aspirin Exacerbated Respiratory Disease
• Asthma
• Aspirin Sensitivity

Interventions

Type	Name	Description
BEHAVIORAL	Low salicylate diet	Participants followed a 7 days period under a Low salicylate diet
BEHAVIORAL	Normal Diet	Participants followed a 7 days period under a Normal Diet

Timeline

• Start date: 2013-05-01
• Primary completion: 2014-03-01
• Completion: 2014-05-01
• First posted: 2013-01-29
• Last updated: 2021-03-09
• Results posted: 2021-03-09

Locations

1 site across 1 country: Canada