NCT01988779

Oral Versus Topical Antibiotics for Chronic Rhinosinusitis Exacerbations

Oral Versus Topical Antibiotic Therapy for Treatment of Chronic Rhinosinusitis Exacerbations

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 33 (actual)
• Sponsor: University of Rochester · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to treat patients with a diagnosis of chronic rhinosinusitis (CRS) and a history of bilateral endoscopic sinus surgery during times of worsening symptoms and signs of acute infection on nasal endoscopy with one of two treatments: (1) oral antibiotics and twice daily intranasal saline irrigations or (2) oral placebo and twice daily intranasal antibiotic irrigations. The two treatments will be compared to see if there is any difference in patient outcomes. This will help guide treatment strategies for patients with CRS in the future.

Detailed description

See brief summary.

Conditions

• Chronic Rhinosinusitis

Interventions

Type	Name	Description
DRUG	oral levofloxacin
DRUG	nebulized levofloxacin

Timeline

• Start date: 2013-10-01
• Primary completion: 2017-09-11
• Completion: 2020-12-31
• First posted: 2013-11-20
• Last updated: 2021-03-24
• Results posted: 2019-12-11

Locations

1 site across 1 country: United States