| Not Yet Recruiting | Blood-Brain Barrier Integrity and Immune Dynamics in Neuropsychiatric Sequelae of Post-SARS-CoV-2 Onset ME/CFS NCT07256795 | Johns Hopkins University | — |
| Recruiting | Hydrogen Water Intervention With Heart Rate Variability as an Outcome Biomarker in ME/CFS NCT07009691 | Stony Brook University | N/A |
| Recruiting | tVNS in Long COVID-19 NCT06585254 | Icahn School of Medicine at Mount Sinai | N/A |
| Not Yet Recruiting | Psychoneuromentalism Disorder: A Medical Condition That Affects People With Psychological Impairments From Hea NCT06235177 | The Essence of Integrative Health and Medicine Practice | EARLY_Phase 1 |
| Recruiting | Lumbrokinase for Adults With Long Covid, Post-treatment Lyme Disease Syndrome, and Myalgic Encephalomyelitis/C NCT06511050 | Icahn School of Medicine at Mount Sinai | Phase 1 / Phase 2 |
| Recruiting | Transcutaneous Vagus Nerve Stimulation as a Complementary Therapy to Exercise in Chronic Fatigue NCT06170645 | Centre Hospitalier Universitaire de Saint Etienne | N/A |
| Not Yet Recruiting | Discovering Trends in Chronic Fatigue Syndrome Patients' Clinical Study Experiences NCT05967494 | Power Life Sciences Inc. | — |
| Enrolling By Invitation | A Feasibility Study: Assessing Photobiomodulation in Myalgic Encephalomyelitis NCT06145867 | Quadram Institute Bioscience | N/A |
| Completed | Compound Ciwujia Granules Treat Chronic Fatigue Syndrome NCT06245642 | Heilongjiang Quanle Pharmaceutical Co., Ltd. | Phase 4 |
| Withdrawn | Chronic Fatigue Etiology in Intensive Care Unit Survivors: the Role of Neuromuscular Function NCT03849326 | Centre Hospitalier Universitaire de Saint Etienne | N/A |
| Recruiting | The Long COVID-19 Wearable Device Study NCT05741112 | Scripps Translational Science Institute | N/A |
| Recruiting | Investigation of Treating Chronic Fatigue Syndrome After COVID With Pharmacotherapy (Pregabalin) or Complex Re NCT05967052 | National Institute of Geriatrics, Rheumatology and Rehabilitation, Poland | Phase 2 |
| Completed | A Multicenter, Adaptive, Randomized, doublE-blinded, Placebo-controlled Study in Participants With Long COVID- NCT06128967 | Cardresearch | Phase 3 |
| Unknown | Exploring Worry in CFS/ME NCT06011135 | King's College London | — |
| Completed | Effect of Stellate Ganglion Block on ME/CFS NCT05664711 | Neuroversion, Inc. | Phase 1 |
| Unknown | Melatonin and Zinc Administration on Cardinal Symptoms in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome NCT05454683 | Laboratorios Viñas, S.A. | N/A |
| Recruiting | Internet-based Treatment for Patients Suffering From Severe Functional Somatic Disorders NCT05525598 | University of Aarhus | N/A |
| Recruiting | Monitoring of Chronic Conditions in Breast Cancer NCT05587777 | Helse Stavanger HF | — |
| Completed | Vagus Nerve Stimulation as Treatment for Long Covid NCT05608629 | Icahn School of Medicine at Mount Sinai | N/A |
| Unknown | Biofeedback and Hydrogen Water as Treatments for Chronic Fatigue Syndrome NCT05397626 | Stony Brook University | Phase 1 |
| Completed | Telerehabilitation for Post COVID-19 Condition NCT05973136 | Université de Sherbrooke | N/A |
| Recruiting | A 3-day Course for CFS/ME NCT05236465 | Norwegian University of Science and Technology | N/A |
| Completed | RESTORE ME -- RCT of Oxaloacetate on Improving Fatigue in ME/CFS NCT05273372 | Terra Biological LLC | N/A |
| Enrolling By Invitation | Quest to Analyze One Thousand Humans Meditating NCT06583395 | Tobias Moeller-Bertram | — |
| Active Not Recruiting | Does a Technology Enabled Multi-disciplinary Team-based Care Model for the Management of Long COVID and Other NCT05167227 | Family Health Centers of San Diego | N/A |
| Active Not Recruiting | A Complex Intervention for Chronically Fatigued Lymphoma Survivors NCT05130099 | Oslo University Hospital | N/A |
| Completed | Clinical Trial to Assess the Improvement of Fatigue, Sleep Problems, Anxiety / Depression, Neurovegetatives Al NCT04301609 | Vitae Health Innovation | N/A |
| Suspended | Tracking Peripheral Immune Cell Infiltration of the Brain in Central Inflammatory Disorders Using [Zr-89]Oxina NCT03807973 | University of Alabama at Birmingham | Phase 1 |
| Active Not Recruiting | Effectiveness and Health Benefits of a Nutritional, Chronobiological and Physical Exercise Intervention in Fib NCT05719493 | Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina | N/A |
| Withdrawn | Feasibility and Acceptability of the Internet-delivered Treatment "One Step at the Time" for Bodily Distress S NCT04870476 | University of Aarhus | N/A |
| Completed | Cardiovascular Analysis of PEM NCT04740736 | Icahn School of Medicine at Mount Sinai | N/A |
| Active Not Recruiting | A Longitudinal Study on Longstanding Complicated Fatigue NCT04955587 | Stockholm University | — |
| Unknown | Influence of Co-diagnosis of Chronic Fatigue Syndrome in Patients With Fibromyalgia. NCT05323838 | University of Extremadura | — |
| Completed | Endothelial Dysfunction in Post-infection Fatigue Syndromes NCT06463106 | FH Joanneum Gesellschaft mbH | — |
| Completed | Exploring the Biological Basis of Chronic Fatigue Syndrome NCT04859257 | DxTerity Diagnostics | — |
| Completed | A Trial of Solriamfetol in the Treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome NCT04622293 | Rochester Center for Behavioral Medicine | Phase 4 |
| Unknown | Structural Problems in Brainstem and Cervical Spine Cord in ME/CFS NCT04403854 | Bragee Clinics | — |
| Recruiting | Assessment of N-Acetylcysteine as Therapy for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome NCT04542161 | Weill Medical College of Cornell University | Phase 2 |
| Unknown | Web-based Rehabilitation for Persistent Physical Symptoms. NCT04532827 | Finnish Institute of Occupational Health | N/A |
| Terminated | Chronic Fatigue Etiology and Recovery in Covid-19 Patients: the Role of Fatigability NCT04363606 | Centre Hospitalier Universitaire de Saint Etienne | N/A |
| Completed | Treatment of Fibromyalgia With Recovery Factors NCT04381780 | Practitioners Alliance Network | N/A |
| Unknown | Effectiveness of VIRTUAL SFCAMINA STUDY NCT04593225 | Hospital Universitari Vall d'Hebron Research Institute | N/A |
| Completed | Effect of Probiotics in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) NCT04741841 | ImmuneBiotech Medical Sweden AB | N/A |
| Unknown | Patient-reported Outcome Measures (PROMs) in Patients With Bodily Stress Syndrome: Protocol for a Prospective NCT04667611 | Helsinki University Central Hospital | — |
| Withdrawn | A Non-Interventional Pilot Study to Explore the Role of Gut Flora in ME/CFS NCT04100915 | ProgenaBiome | — |
| Completed | The Exercise Response to Pharmacologic Cholinergic Stimulation in Myalgic Encephalomyelitis / Chronic Fatigue NCT03674541 | Brigham and Women's Hospital | Phase 2 |
| Completed | Vestibulodynia: Understanding Pathophysiology and Determining Appropriate Treatments NCT03844412 | Duke University | Phase 2 |
| Completed | ME/CFS, Hypermobility and Craniocervical Obstructions NCT04399330 | Bragee Clinics | — |
| Completed | Treatment of CFS & Fibromyalgia With Recovery Factors NCT04381793 | Practitioners Alliance Network | N/A |
| Completed | Hydrogen Water Treatment for Chronic Fatigue Syndrome NCT05013606 | Stony Brook University | N/A |
| Completed | The Comeback Study NCT03691987 | University Hospital of North Norway | Phase 2 |
| Recruiting | Assessment of Neuroinflammation in Central Inflammatory Disorders Using [F-18]DPA-714. NCT03759522 | University of Alabama at Birmingham | Phase 1 |
| Completed | Analysis of Post-exertional Malaise Using a Two-day CPET in People With ME/CFS NCT04026425 | Ithaca College | N/A |
| Completed | Clinical Trial to Investigate CT38 in the Treatment of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome NCT03613129 | LUCINDA BATEMAN, MD | Phase 1 / Phase 2 |
| Completed | Developing an Activity Pacing Framework: Feasibility and Acceptability NCT03497585 | Pennine Acute Hospitals NHS Trust | — |
| Unknown | New MRT Imaging Biomarkers and Treatment With Kinetic Oscillatory Stimulation (KOS) in Nasal Cavity for Myalgi NCT03502044 | Karolinska University Hospital | N/A |
| Unknown | Exercise-related Post-exertional Malaise NCT03331419 | Stony Brook University | — |
| Completed | Autoimmunity in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) NCT03254823 | University of East Anglia | — |
| Completed | Coenzyme Q10 Plus NADH Supplementation in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis NCT03186027 | Hospital Universitari Vall d'Hebron Research Institute | N/A |
| Unknown | Complex Chronic Diseases Program Data Registry NCT03409653 | BC Women's Hospital & Health Centre | — |
| Completed | Central Mechanisms of Chronic Pain and Fatigue Subtitle: Functional Imaging of Brain and Spinal Cord NCT03075254 | University of Florida | — |
| Completed | Noradrenergic and Stress-Related Etiologies of Chronic Fatigue Syndrome NCT03029377 | Vanderbilt University Medical Center | N/A |
| Unknown | Thunder-Fire Moxibustion Therapy for Chronic Fatigue Syndrome on Shenque Acupoint: a Randomized Controlled Tri NCT02964533 | Guangzhou University of Chinese Medicine | N/A |
| Unknown | High-tech Acupuncture for Treatment of Chronic Fatigue Syndrome NCT02924831 | Hubei Provincial Collaborative Innovation Center of Preventive Treatment by Acupuncture and Moxibust | Phase 2 |
| Completed | Myalgic Encephalomyelitis Chronic Fatigue at the National Institutes of Health NCT02669212 | National Institute of Neurological Disorders and Stroke (NINDS) | N/A |
| Unknown | A Clinical Study About Improvement of Chronic Fatigue After Taking Red Ginseng NCT02847845 | Eun Jung Kim | N/A |
| Unknown | ME/CFS: Activity Patterns and Autonomic Dysfunction NCT02948556 | Stony Brook University | — |
| Unknown | Reducing Orthostatic Intolerance With Oral Rehydration in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome P NCT02854683 | New York Medical College | Phase 1 |
| Active Not Recruiting | Creatine Supplementation in Chronic Fatigue Syndrome NCT02374112 | Center for Health Sciences, Serbia | N/A |
| Completed | Effect of Ginko and Cistanche Against Fatigue Symptoms NCT02807649 | Access Business Group | N/A |
| Completed | Guanidinoacetic Acid Loading for Chronic Fatigue Syndrome NCT02213679 | Center for Health Sciences, Serbia | N/A |
| Completed | Cytokine Inhibition in Chronic Fatigue Syndrome Patients NCT02108210 | Radboud University Medical Center | Phase 2 / Phase 3 |
| Completed | Cardiopulmonary Testing in ME/CFS to Improve Diagnostic Accuracy NCT02970240 | University of Oslo | — |
| Terminated | Whole Body Hyperthermia Registry Study NCT02174003 | University of Arizona | — |
| Completed | Psychological Wellbeing in Chronic Fatigue Syndrome NCT02094820 | Royal Holloway University | — |
| Completed | Traditional African Healing Ceremony in a U.S. Population NCT01873482 | Duke University | N/A |
| Completed | SWS And Daytime Functioning in Chronic FatiguE Syndrome (SAFFE) NCT02055898 | Imperial College London | Phase 4 |
| Completed | Exertional Exhaustion in Chronic Fatigue Syndrome NCT03567811 | Georgetown University | N/A |
| Unknown | Use of a Monitor in ME/CFS NCT01908036 | New York CFS Association | — |
| Withdrawn | Sodium Oxybate in Patients With Chronic Fatigue Syndrome. NCT01584934 | University Hospital, Ghent | Phase 4 |
| Unknown | Observational Research on Use of Immunoprop Supplement in Chronic Fatigue Syndrome NCT01893619 | New York CFS Association | — |
| Completed | Efficacy and Safety of Fermented Velvet Antler Extract on Fatigue Recovery After Exercise NCT01689467 | Chonbuk National University Hospital | N/A |
| Completed | A Rehabilitation Program for Adolescents With Chronic Fatigue Syndrome NCT01806246 | St. Olavs Hospital | N/A |
| Unknown | Clinical Trial to Evaluate the Effectiveness of Acupuncture as a Treatment in Patients Diagnosed With CFS. NCT01907711 | Hospital Vall d'Hebron | Phase 2 / Phase 3 |
| Unknown | Treatment of Chronic Fatigue Syndrome (CFS) With Iodinated Activated Charcoal (IodoCarb®) NCT01793415 | PharmaLundensis AB | Phase 1 / Phase 2 |
| Completed | Clinical Trial to Measure the Maximun HR After ReConnect ® Supplementation vs. Placebo in CFS. NCT02063126 | Hospital Universitari Vall d'Hebron Research Institute | Phase 2 / Phase 3 |
| Completed | Investigator Initiated Clinical Study to Explore the Efficacy and Safety of Human Placenta Hydrolysate in the NCT01742013 | Ho Cheol Shin, M.D., Ph.D. | Phase 3 |
| Completed | The Feasibility, Acceptability and Clinical Utility of a New Remote-mobile Technology Intervention (ASARM) for NCT02082730 | Manchester University NHS Foundation Trust | N/A |
| Completed | ACT for ME/CFS - an Open Case Trial NCT03562325 | Rikard Wicksell | N/A |
| Terminated | Tumor Necrosis Factor-alpha Inhibition Using Etanercept in Chronic Fatigue Syndrome NCT01730495 | Haukeland University Hospital | Phase 2 |
| Completed | Acupressure for Pain Management and Fatigue Relief in Gulf War Veterans NCT02075489 | The Cleveland Clinic | N/A |
| Completed | Motor Control in Chronic Fatigue Syndrome and Fibromyalgia NCT01686074 | Norwegian University of Science and Technology | — |
| Withdrawn | Chronic Fatigue Syndrome: A Presumptive Mitochondrial Disorder NCT01471652 | Columbia University | Phase 2 |
| Completed | Welfare Benefits in Functional Somatic Disorders NCT05611606 | University of Aarhus | — |
| Completed | Psychiatric Disorders and Functional Somatic Disorders NCT06006715 | Aarhus University Hospital | — |
| Completed | Health Care Use and Costs of Functional Somatic Disorders NCT05811663 | Aarhus University Hospital | — |
| Completed | Psychological Risk Factors for Functional Somatic Disorders NCT05631860 | University of Aarhus | — |
| Withdrawn | Therapy for Chronic Fatigue Syndrome: A Presumptive Mitochondrial Disorder NCT01872351 | Columbia University | — |
| Completed | Pacing Activity Self-management for Patients With Chronic Fatigue Syndrome NCT01512342 | Vrije Universiteit Brussel | Phase 2 |
| Completed | Coping With Chronic Fatigue Syndrome: Development of a Community-based Patient Education Program NCT01765725 | Oslo University Hospital | N/A |
| Completed | Acupuncture for the Sleep Disorder of Chronic Fatigue Syndrome NCT01534130 | Chengdu University of Traditional Chinese Medicine | N/A |
| Completed | B-cell Depletion Using the Monoclonal Anti-CD20 Antibody Rituximab in Chronic Fatigue Syndrome NCT01156909 | Haukeland University Hospital | Phase 2 |
| Completed | Patient-Partner Stress Management Effects on Chronic Fatigue Syndrome Symptoms and Neuroimmune Process NCT01650636 | University of Miami | N/A |
| Completed | Humoral and Cellular Immune Responses After Influenza Vaccination in Patients With Postcancer Fatigue and in P NCT01651754 | Radboud University Medical Center | N/A |
| Terminated | Study To Assess The Clinical Benefit Of Droxidopa In Subjects With Chronic Fatigue Syndrome NCT00977171 | Chelsea Therapeutics | Phase 2 |
| Terminated | B-cell Depletion Using the Monoclonal Anti-CD20 Antibody Rituximab in Very Severe Chronic Fatigue Syndrome NCT01156922 | Haukeland University Hospital | Phase 2 |
| Completed | The Norwegian Study of Chronic Fatigue Syndrome in Adolescents: Pathophysiology and Intervention Trial NCT01040429 | Oslo University Hospital | Phase 2 |
| Completed | Pilot Study for the NorCAPITAL Trial NCT01507701 | Oslo University Hospital | N/A |
| Completed | Efficacy and Safety of Lisdexamfetamine Dimesylate in Adults With Chronic Fatigue Syndrome NCT01071044 | Rochester Center for Behavioral Medicine | Phase 4 |
| Completed | A Pilot Study of Amygdala Retraining Program in Patients With Chronic Fatigue Syndrome, Chronic Fatigue and Fi NCT01046370 | Mayo Clinic | N/A |
| Completed | Survey and Cognitive Behavior Therapy for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis NCT00920777 | Norwegian University of Science and Technology | N/A |
| Completed | Treatment of Chronic Fatigue Syndrome and Fibromyalgia With D-ribose- a Multicenter Study NCT01108549 | Kona Research Center | N/A |
| Completed | Giardia Induced Fatigue and Functional Gastrointestinal Diseases NCT00860236 | University of Bergen | Phase 4 |
| Completed | Fatigue Self-Management in Primary Care NCT00997451 | Stony Brook University | N/A |
| Terminated | Pilot Study of Alternative Treatments of Unexplained Chronic Fatigue NCT00983502 | University of Utah | — |
| Completed | Drug Intervention in Chronic Fatigue Syndrome NCT00848692 | Haukeland University Hospital | Phase 2 / Phase 3 |
| Completed | Efficacy of Web-based Cognitive Behavioural Treatment for Adolescents With Chronic Fatigue Syndrome NCT00893438 | UMC Utrecht | N/A |
| Completed | Behavioral Insomnia Therapy With Chronic Fatigue Syndrome NCT00540254 | Duke University | Phase 1 / Phase 2 |
| Completed | Immune Patterns in Pain Patients DSM-IV NCT01106339 | University of Ulm | — |
| Completed | Proteomics of Cerebrospinal Fluid in Chronic Fatigue Syndrome NCT00810329 | Georgetown University | — |
| Terminated | Use of Xyrem to Improve Sleep in Chronic Fatigue Syndrome NCT00498485 | University of Medicine and Dentistry of New Jersey | Phase 4 |
| Completed | Valganciclovir (Valcyte) for Chronic Fatigue Syndrome Patients Who Have Elevated Antibody Titers Against Human NCT00478465 | Stanford University | Phase 1 / Phase 2 |
| Completed | Autonomic Nervous System and Chronic Fatigue Syndrome NCT00580619 | Vanderbilt University | Phase 1 |
| Completed | A Computer-Based Intervention for Medically Unexplained Physical Symptoms NCT00468013 | University of Medicine and Dentistry of New Jersey | N/A |
| Completed | Epstein-Barr Virus as a Possible Cause for Chronic Fatigue Syndrome NCT00433355 | University of Mississippi Medical Center | — |
| Completed | Sleep Disordered Breathing in Gulf War Illness and the Effect of Nasal CPAP Treatment NCT00252629 | US Department of Veterans Affairs | N/A |
| Completed | Use of Sildenafil (Viagra) to Alter Fatigue, Functional Status and Impaired Cerebral Blood Flow in Patients Wi NCT00598585 | Charles Drew University of Medicine and Science | Phase 4 |
| Completed | Hyporeactivity and Gulf War Illness NCT00100412 | US Department of Veterans Affairs | N/A |
| Unknown | Genetics of Fibromyalgia NCT00071162 | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) | — |
| Completed | The Study of the Safety and Efficacy of Ampligen in Chronic Fatigue Syndrome NCT00215800 | AIM ImmunoTech Inc. | Phase 3 |
| Completed | Compare the Medical Conditions of Gulf War Veterans to Non-Deployed Veterans NCT00032461 | US Department of Veterans Affairs | — |
| Unknown | Essential Hypotension and Allostasis Registry NCT02018497 | CES University | — |
| Temporarily Not Available | Ampligen in Chronic Fatigue Syndrome NCT00215813 | AIM ImmunoTech Inc. | — |