NCT04363606

Chronic Fatigue Etiology and Recovery in Covid-19 Patients: the Role of Fatigability

Chronic Fatigue Etiology and Recovery in Covid-19 Patients : the Role of Fatigability and Stay in Intensive Care

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 69 (actual)
• Sponsor: Centre Hospitalier Universitaire de Saint Etienne · Academic / Other
• Sex: All
• Age: 35 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Chronic fatigue is the most common and debilitating symptom in intensive care unit (ICU) survivors. Indeed, it has been widely reported that patients who stayed in ICU for prolonged periods report a feeling of tiredness for months to years after ICU discharge. This symptom seems particularly pronounced in Covid-19 patients and may affect their quality of life by decreasing their capacity to perform simple tasks of daily life. The aim of the present project is to determine whether deteriorated neuromuscular function (i.e. increased fatigability) is involved in the feeling of fatigue of Covid-19 patients. Because the causes of this feeling are multi-dimensional, a large battery of tests will allow us to better understand the origin of chronic fatigue. A better knowledge of chronic fatigue etiology and its recovery will allow to optimize rehabilitation treatments to shorten the persistence of chronic fatigue and in fine improve life quality.

Conditions

• Chronic Fatigue Syndrome
• Intensive Care Unit
• Muscle

Interventions

Type	Name	Description
OTHER	Questionnaires	Quality of life Depression Physical pain Social provisions Quality of sleep
BIOLOGICAL	blood test	complete blood count and cytokine concentration, TNF-alpha, LDL oxidized, AOPP, SOD, GPX, catalase, albumin, transthyretin, RBP, transferin, α-1 glycoprotein acide, ferritine, selenium, zinc, magnesium
OTHER	Maximal effort test	The maximal effort test with VO2max recordings will be assessed during the first visit to the laboratory.
DEVICE	actigraphy	assessment of sleep quality
DEVICE	Neuromuscular evaluation	* The maximum isometric force produced by the knee extensors will be measured on the ergometer * the intensity of muscular electrical activity recorded by surface electromyography * Peripheral nerve stimulation * Transcranial magnetic stimulation * Magnetic resonance imaging
OTHER	stool analysis	analyze the composition of the intestinal microbiote. concerns only the patients of Saint Etienne
OTHER	food diary	3 days of information to determine nutrient intakes. concerns only the patients of Saint Etienne

Timeline

• Start date: 2020-05-27
• Primary completion: 2021-08-26
• Completion: 2022-03-01
• First posted: 2020-04-27
• Last updated: 2025-03-25

Locations

8 sites across 1 country: France