| Not Yet Recruiting | MRI-Based Lesion Differentiation in Older Patients With Multiple Sclerosis NCT07444047 | Oslo University Hospital | — |
| Not Yet Recruiting | Songling Xuemaikang Capsules for Cerebral Small Vessel Disease NCT07271732 | Dongzhimen Hospital, Beijing | N/A |
| Not Yet Recruiting | Isosorbide Mononitrate and Butylphthalide to Reduce the Risk of Disability in Patients With Acute Lacunar Stro NCT07252544 | Beijing Tiantan Hospital | Phase 3 |
| Recruiting | Registry Study of Cerebral Small Vessel Disease NCT07342075 | Dongzhimen Hospital, Beijing | — |
| Not Yet Recruiting | A Multicenter, Randomized, Double-blind, Placebo-controlled Trial on the Treatment of Hypertensive Intracerebr NCT07200921 | Beijing Tiantan Hospital | Phase 2 |
| Not Yet Recruiting | Prospective Randomized Controlled Trial of VR Cognitive Training in Reducing Postoperative Delirium in Elderly NCT06999668 | Peking University Third Hospital | N/A |
| Recruiting | Intermittent Theta Burst Stimulation on Cognitive Impairment of Cerebral Small Vessel Disease NCT06579664 | Beijing Tiantan Hospital | N/A |
| Recruiting | Retinal Vessel Leakage in Cerebral Small Vessel Disease NCT06416371 | University of Edinburgh | — |
| Enrolling By Invitation | Testing of a System for Remote Ischemic Conditioning in Cerebral Small Vessel Disease and Pre-hospital Stroke NCT05967728 | University of Calgary | Phase 2 |
| Recruiting | PRospective Observation on CErebral microvaScular Structure and Function NCT06579677 | Beijing Tiantan Hospital | — |
| Recruiting | Efficacy and Safety of Calculus Bovis Sativus (CBS) for Ischemic Cerebral Vascular Disease (CBSinICVD) NCT06474507 | Tongji Hospital | N/A |
| Not Yet Recruiting | The Effect of Anthocyanin Intake From Purple Sweet Potato in Cerebral Small Vessel Disease NCT06380465 | Indonesia University | N/A |
| Recruiting | Fundus Optical coheRence Tomography Angiography Evaluation for Small-vessel Health in Cerebral Small Vessel Di NCT06431711 | Zhejiang Provincial People's Hospital | — |
| Unknown | Stellate Ganglion Block in Patients With Cerebral Small Vessel Disease NCT06319495 | Copka Sonpashan | N/A |
| Unknown | Effect of Multifunctional Nutrition Tube on Cerebral Small Vessel Disease Patients NCT06328842 | Copka Sonpashan | N/A |
| Unknown | Investigation of Potential Mechanisms in Stellate Ganglion Block in Individuals With Cerebral Small Vessel Dis NCT06301711 | Ahmadu Bello University Teaching Hospital | N/A |
| Unknown | Effect of Multifunctional Nutrition Tube on Cerebral Small Vessel Disease Patients NCT06265857 | Zeng Changhao | N/A |
| Unknown | The Effect of Oral and Nasal Feeding on Cerebral Small Vessel Disease NCT06248892 | Zeng Changhao | N/A |
| Completed | Exploration of Stellate Ganglion Block in Patients With Cerebral Small Vessel Disease NCT06226415 | Zeng Changhao | N/A |
| Recruiting | Dementia Risk Registry for Young and Middle-aged CSVD Patients in the Next 10 Years NCT06164262 | Zhejiang Provincial People's Hospital | — |
| Not Yet Recruiting | A Registry Study of Microcirculation Disorder After Cerebral Small Vessel Disease and Ischemic Stroke NCT06077305 | Beijing Tiantan Hospital | — |
| Not Yet Recruiting | Tongxinluo Capsule in the Treatment of Cerebral Small Vessel Disease-A Randomized, Double-blind, Placebo-contr NCT06061692 | Fudan University | Phase 4 |
| Unknown | Effect of Menopause Hormone Therapy In Postmenopausal Women With CSVD And MCI NCT05982470 | Beijing Tiantan Hospital | Phase 2 |
| Recruiting | Revascularization Effect on CSVD Burden in Carotid Artery Stenosis NCT06031610 | Zhejiang Provincial People's Hospital | — |
| Unknown | Establishment of a CSF Bank for the Development of Biomarkers of Smooth Muscle Cell (SMC) Damage in Monogenic NCT05793424 | Assistance Publique - Hôpitaux de Paris | — |
| Recruiting | WHIte MAtter Hyperintensity Shape and Glymphatics NCT06010511 | Leiden University Medical Center | — |
| Recruiting | Feedback Loop Between Intracranial Atherosclerosis and Cerebral Small Vessel Disease NCT05677607 | Chinese PLA General Hospital | — |
| Terminated | Intermittent Oro-esophageal Tube Feeding on Cerebral Small Vessel Disease Patients With Dysphagia NCT06179550 | Zeng Changhao | N/A |
| Completed | Effect of Oral Enteral Nutrition on Cerebral Small Vessel Disease NCT06303999 | Muhammad | N/A |
| Recruiting | Stopping Cognitive Decline and Dementia by Fighting Covert Cerebral Small Vessel Disease NCT05306834 | University Hospital, Bordeaux | N/A |
| Unknown | Neuroimaging Combining Biomarkers for Identifying Long-term Cognitive Dysfunction and Delirium NCT05594966 | RenJi Hospital | — |
| Unknown | Efficacy of Pentoxifylline on Cerebrovascular Function in Patients With Cerebral Small Vessel Disease(PERFORM) NCT05583266 | Beijing Tiantan Hospital | Phase 4 |
| Recruiting | INflammation and Small Vessel Disease Study NCT05746221 | University of Cambridge | — |
| Active Not Recruiting | Hereditary Cerebral Small Vessel Diseases Registry-Trial Ready Cohort NCT06512376 | Beijing Tiantan Hospital | — |
| Unknown | MRI-markers to Monitor Small Vessel Disease Dynamics in the Prognosis of Small Vessel Disease-associated, Cere NCT05773235 | Insel Gruppe AG, University Hospital Bern | — |
| Unknown | CerebrAlcare Pills on CereBral Small VesseL DiseasE（CABLE） NCT05578521 | Beijing Tiantan Hospital | Phase 4 |
| Active Not Recruiting | Improving Cerebral Blood Flow and Cognition in Patients with Cerebral Small Vessel Disease. the ETLAS-2 Trial NCT05173896 | Christina Kruuse | Phase 2 |
| Unknown | Functional Prognosis of Post-operative Patients With Cerebral Small Vascular Disease(CSVD) NCT05359588 | RenJi Hospital | — |
| Unknown | Magnetic Resonance Imaging in Cerebral Small Vessel Disease NCT05200377 | Chinese PLA General Hospital | — |
| Not Yet Recruiting | Folic Acid and Intensive Antihypertensive Therapy for Hypertension With CSVD NCT05169021 | Beijing Tiantan Hospital | Phase 4 |
| Unknown | Effects of Remote Ischemic Conditioning on Dynamic Cerebral Autoregulation, Blood Pressure and Heart Rate Vari NCT05225948 | Yi Yang | N/A |
| Completed | Circuit Training and Retina NCT05714813 | University of Miami | N/A |
| Unknown | Retinal, Cerebral and Vascular Precursor Markers of Cerebral Small Vessel Disease. NCT05305144 | University Hospital, Bordeaux | N/A |
| Unknown | White Matter Hyperintensities Subtypes in Cerebral Small Vessel Disease : 7 Tesla Ultra-high Resolution Imagin NCT04298866 | Assistance Publique - Hôpitaux de Paris | N/A |
| Recruiting | Retina is a Marker for Cerebrovascular Heath NCT04753970 | Mayo Clinic | Phase 1 / Phase 2 |
| Completed | Stellate Ganglion Block in Patients With Cerebral Small Vessel Disease NCT06176404 | Zeng Changhao | N/A |
| Unknown | Periodic Limb Movement Syndrome in Patients With Cerebral Small Vessel Disease. NCT04569643 | I.M. Sechenov First Moscow State Medical University | — |
| Recruiting | Cohort Study of Inpatients and Outpatient Patients With Cerebral Small Vessel Disease NCT05985213 | Shanghai Yueyang Integrated Medicine Hospital | — |
| Recruiting | China Imaging-based Biobank of Cerebral Small Vessal Diseases NCT04962295 | Peking University Third Hospital | — |
| Unknown | Cerebral Small Vessel Disease and Perioperative Covert Stroke NCT04443933 | RenJi Hospital | — |
| Unknown | Cambridge 7 Tesla Cerebral Small Vessel Disease Study NCT04330222 | University of Cambridge | — |
| Terminated | Triple Therapy Prevention of Recurrent Intracerebral Disease EveNts Trial (TRIDENT) Cognitive Sub-Study NCT03785067 | The George Institute | Phase 3 |
| Recruiting | Cerebral Small Vessel Disease Registry Study NCT04318119 | Bin Cai | — |
| Unknown | Trial of Remote Ischemic Pre-conditioning in Vascular Cognitive Impairment NCT04109963 | University of Calgary | Phase 2 |
| Unknown | Clinical Observation for the Therapeutic Effect of mNGF on Cognitive Decline in Cerebral Small Vessel Disease NCT04041349 | Zhujiang Hospital | Phase 4 |
| Unknown | Cerebrovascular Correlates of Dementia in Rural Communities - The Three Villages Study NCT04123171 | Universidad de Especialidades Espiritu Santo | — |
| Unknown | Remote Ischemic Conditioning on Cerebral Small Vessel Disease NCT04816500 | Capital Medical University | N/A |
| Recruiting | Taiwan Associated Genetic and Nongenetic Small Vessel Disease NCT05473637 | National Taiwan University Hospital | — |
| Terminated | Triple Therapy Prevention of Recurrent Intracerebral Disease EveNts Trial Magnetic Resonance Imaging Sub-study NCT03783754 | The George Institute | N/A |
| Unknown | A Clinical Study on the Treatment of Cerebral Small Vascular Disease NCT04078204 | Peking Union Medical College Hospital | N/A |
| Terminated | Effects of Amlodipine and Other Blood Pressure Lowering Agents on Microvascular Function NCT03082014 | Ludwig-Maximilians - University of Munich | Phase 3 |
| Completed | LACunar Intervention (LACI-2) Trial-2 NCT03451591 | University of Edinburgh | Phase 2 / Phase 3 |
| Unknown | The Efficacy of DL-NBP in Patients With Mild Subcortical Ischemic Vascular Dementia NCT03906123 | Tianjin Medical University General Hospital | N/A |
| Completed | Effect of Tadalafil on Cerebral Large Arteries in Stroke NCT02801032 | Christina Kruuse | Phase 2 |
| Completed | Lacunar Intervention Trial 1 (LACI-1) NCT02481323 | University of Edinburgh | Phase 2 |
| Completed | Stroke Imaging Package Study NCT02485275 | Wei-Hai Xu | — |
| Completed | Recovery Improved in Covert Stroke With Exercise NCT02068391 | Sunnybrook Health Sciences Centre | N/A |
| Terminated | Effect of Hyperbaric Oxygen on Functional Connectivity in Patients With Cerebral Small Vessel Disease NCT02890888 | St. Luke's Hospital, Chesterfield, Missouri | N/A |
| Unknown | Visit-to-Visit Variability in Blood Pressure as a Predictor of Poor Cognitive Function NCT01688505 | Hallym University Medical Center | — |
| Unknown | Stratification of Blood Pressure Control Against Progress of Cerebral Small Vessel Diseases in Poststroke Pati NCT01819441 | Yining Huang | Phase 4 |
| Recruiting | Cognitive Impairment, Retinopathy, and Cerebrovascular Lesions in the Elderly NCT03542734 | Second Affiliated Hospital, School of Medicine, Zhejiang University | — |