NCT04330222

Cambridge 7 Tesla Cerebral Small Vessel Disease Study

Imaging the Arterial Pathology in Cerebral Small Vessel Disease Using 7 Tesla Magnetic Resonance Imaging

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 210 (estimated)
• Sponsor: University of Cambridge · Academic / Other
• Sex: All
• Age: 18 Years – 99 Years
• Healthy volunteers: Accepted

Summary

CamSVD is jointly sponsored by the University of Cambridge and Cambridge University Hospitals NHS Foundation Trust. We aim to explore and understand the underlying arterial pathology in Cerebral Small Vessel Disease (SVD) using ultra-high-field 7 Tesla MRI. We will optimise 7T Time-of-Flight MR angiography, blood suppressed MR sequence and phase-contrast (PC) MR angiography for visualization of perforating lenticulostriate arteries. This optimised sequences will be used to determine the range of arterial pathologies seen in individuals presenting with lacunar strokes. The pathologies of the perforating lenticulostriate arteries will be correlated with conventional clinical risk factors, cognition and radiological markers of SVD.

Conditions

• Cerebral Small Vessel Diseases
• Cerebral Small Vessel Ischemic Disease
• Lacunar Stroke

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	7 Tesla Magnetic Resonance Imaging	Diagnostic Imaging
OTHER	Brief Memory and Executive Test	Cognitive Assessment

Timeline

• Start date: 2020-03-09
• Primary completion: 2024-01-12
• Completion: 2024-01-12
• First posted: 2020-04-01
• Last updated: 2022-09-21

Locations

1 site across 1 country: United Kingdom