Trials / Recruiting
RecruitingNCT05473637
Taiwan Associated Genetic and Nongenetic Small Vessel Disease
Deciphering, Construction and Validation of Magnetic Resonance Imaging Maps, Clinical Features and Outcomes in Genetic and Nongenetic Cerebral Small Vessel Diseases
- Status
- Recruiting
- Phase
- —
- Study type
- Observational
- Enrollment
- 500 (estimated)
- Sponsor
- National Taiwan University Hospital · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Accepted
Summary
The TAG-SVD enrolled patients with clinical and neuroimaging features of cerebral small vessel disease (CSVD). All enrolled patients will receive next-generation sequence (NGS) with probes designed to target five candidate CSVD genes, and patients will be divided into genetic or non-genetic groups accordingly. Their clinical features and outcome will be followed for at least 2 years.
Conditions
- Cerebral Small Vessel Diseases
- Cadasil
- HTRA1-Related Autosomal Dominant Cerebral Angiopathy
- COL4A1-Related Brain Small Vessel Disease With Haemorrhage
- Fabry Disease
- Magnetic Resonance Imaging
- Next-generation Sequencing
- Stroke
Interventions
| Type | Name | Description |
|---|---|---|
| DIAGNOSTIC_TEST | MRI | Patients will repeat study-protocol MRI at baseline (enrollment) and at least once in 1 year or 2 years follow-up (depends on availability). |
Timeline
- Start date
- 2019-01-01
- Primary completion
- 2026-12-31
- Completion
- 2028-12-31
- First posted
- 2022-07-26
- Last updated
- 2026-01-20
Locations
1 site across 1 country: Taiwan
Source: ClinicalTrials.gov record NCT05473637. Inclusion in this directory is not an endorsement.