Trials / Recruiting
RecruitingNCT06164262
Dementia Risk Registry for Young and Middle-aged CSVD Patients in the Next 10 Years
Dementia Risk rEgistry for Young And Middle-aged CSVD Patients in the Next 10 Years（DREAM-10）
- Status
- Recruiting
- Phase
- —
- Study type
- Observational
- Enrollment
- 1,000 (estimated)
- Sponsor
- Zhejiang Provincial People's Hospital · Academic / Other
- Sex
- All
- Age
- 30 Years – 60 Years
- Healthy volunteers
- —
Summary
Age-related cerebral small-vessel disease (CSVD) is a major cause of dementia, predominantly affecting individuals over 60 years of age, with a prevalence exceeding 70% in the elderly population. However, the correlation between the burden of CSVD and the progression of cognitive impairment in young and middle-aged individuals remains uncertain. DREAM-10 is an observational, prospective study that enrolled individuals aged 30-60 years, who were free from known dementia but exhibited imaging markers related to CSVD. Through prospective registration and follow-up, this study will collect data on patients with CSVD, including clinical information, neuropsychological assessments, multimodal Magnetic Resonance Images (MRI) and retinopathy characterized by Optical Coherence Tomography Angiography (OCTA). CSVD related features seen on neuroimaging include recent small subcortical infarcts, lacunes, white matter hyperintensities, perivascular spaces, microbleeds, brain atrophy, cortical superficial siderosis. Utilizing this data, the researchers aim to investigate the potential dementia risk among young and middle-aged individuals with CSVD over the forthcoming decade, along with identifying its predictive factors.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | Individuals with CSVD | This does not entail the application of interventions. |
Timeline
- Start date
- 2024-01-01
- Primary completion
- 2034-08-01
- Completion
- 2034-12-01
- First posted
- 2023-12-11
- Last updated
- 2025-05-21
Locations
1 site across 1 country: China
Source: ClinicalTrials.gov record NCT06164262. Inclusion in this directory is not an endorsement.