NCT05985213

Cohort Study of Inpatients and Outpatient Patients With Cerebral Small Vessel Disease

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 1,078 (estimated)
• Sponsor: Shanghai Yueyang Integrated Medicine Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

This cohort study involves the dynamic collection of clinical information, including serum parameters , blood pressure variability, imaging data, and neuropsychological scales, in patients with cerebral small vessel disease (CSVD). The study aims to summarise the clinical and imaging characteristics of the CSVD population and identify novel CSVD risk factors. Additionally, this study intend to uncover the mechanisms underlying the clinical and imaging outcomes of CSVD. Furthermore, a multivariable prediction model for cognitive and mood disorders in patients with CSVD will be established.

Detailed description

Research Objectives: 1. To conduct a longitudinal study on patients with cerebral small vessel disease (CSVD) and observe the dynamic evolution of their cognitive functioning, emotional disorders, and other related factors. 2. To explore and summarize the clinical and radiological characteristics of the CSVD population, and identify new risk factors for CSVD. 3. To investigate in depth the underlying mechanisms and the relationship between clinical and radiological outcomes in CSVD. 4. To establish a multifactor prediction model for cognitive and emotional disorders in CSVD.

Conditions

• Cerebral Small Vessel Diseases

Interventions

Type	Name	Description
OTHER	data collection and follow-up	Main measures and data collection methods: 1. Recording of baseline demographic and clinical information of the participants. 2. Multimodal magnetic resonance imaging 3. blood pressure variability. 4. neuropsychological testing 5. Blood samples collection

Timeline

• Start date: 2020-12-01
• Primary completion: 2027-12-31
• Completion: 2028-12-31
• First posted: 2023-08-14
• Last updated: 2023-08-14

Locations

1 site across 1 country: China