NCT05677607

Feedback Loop Between Intracranial Atherosclerosis and Cerebral Small Vessel Disease

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 300 (estimated)
• Sponsor: Chinese PLA General Hospital · Academic / Other
• Sex: All
• Age: 30 Years
• Healthy volunteers: Not accepted

Summary

The present study aims at verifying the mutual effects between intracranial large artery atherosclerosis and cerebral small vessel disease on disease progression and prognosis by magnetic resonance imaging, and providing biomarkers for the early prevention and treatment of cerebrovascular disease.

Detailed description

Cerebrovascular disease is the most common cause of death worldwide. There is a close link in structure and function between the intracranial large arteries and cerebral small vessels. Moreover, growing evidences have demonstrated that large artery atherosclerosis often coexists with small vessel disease, which may deteriorate the clinical outcomes of stroke and dementia. The mutual feedback mechanism between them is not fully understood. The present study focuses on the mechanism of mutual feedback between large artery atherosclerosis and cerebral small vessel disease by using magnetic resonance imaging. The study may provide biomarkers for the early prevention and treatment of cerebrovascular disease.

Conditions

• ICAS - Intracranial Atherosclerosis
• Cerebral Small Vessel Diseases

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Magnetic resonance imaging	Imaging diagnostics mainly based on Magnetic resonance imaging.

Timeline

• Start date: 2023-01-01
• Primary completion: 2027-12-31
• Completion: 2027-12-31
• First posted: 2023-01-10
• Last updated: 2024-07-03

Locations

1 site across 1 country: China