| Recruiting | Comparing the Attentional Demands and Functional Outcomes in People With Transradial Amputation NCT07075042 | Virginia Commonwealth University | N/A |
| Not Yet Recruiting | Influence Of A Slope Adaptive Foot On Participation Of Veterans With Lower-Limb Amputations NCT07266077 | VA Office of Research and Development | N/A |
| Not Yet Recruiting | TOE Study: Treatment and Gait Analysis fOllowing an Excised Lesser Toe NCT07441772 | University of Huddersfield | N/A |
| Not Yet Recruiting | Prosthetic Socket Fit Testing System NCT07491614 | University of Washington | N/A |
| Not Yet Recruiting | Evacuation Time and Tourniquet Use as Risk Factors for PTSD in Combat-Related Amputation NCT07502313 | Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans) | — |
| Recruiting | Assessing Ambulatory and Non-ambulatory Community Mobility in People With Lower Limb Amputation NCT07387744 | Virginia Commonwealth University | N/A |
| Not Yet Recruiting | Advancing Antimicrobial Photodynamic Therapy to Prevent Infection in Osseointegrated Prosthesis Patients NCT06777511 | Dartmouth-Hitchcock Medical Center | — |
| Recruiting | Amputations in Childhood and Neuropathic Pain NCT07401966 | Hopitaux de Saint-Maurice | — |
| Recruiting | Evaluation of Myoelectric Implantable Recording Array (MIRA) in Participants With Transradial Amputation NCT05768802 | Boninger, Michael, MD | N/A |
| Not Yet Recruiting | Pilot Feasibility Trial of a Peer Support Program for Trauma Survivors NCT07275892 | Sunnybrook Health Sciences Centre | N/A |
| Not Yet Recruiting | Neuromusculoskeletal Interface for Bionic Arms NCT07032753 | Shirley Ryan AbilityLab | N/A |
| Not Yet Recruiting | Combined Local Anesthetic Blockade and Neuromodulation vs Local Anesthetic Blockade Only for Analgesia After B NCT06964347 | Stanford University | N/A |
| Recruiting | Gait Training and Artificial Intelligence NCT07265154 | South Valley University | N/A |
| Recruiting | Impact Evaluation of Breizh Fabribus Intervention for Personalized Assistive Technology Creation or Adaptation NCT07314099 | Fondation Ildys | — |
| Recruiting | Influence of Prosthetic Foot Stiffness on Transtibial Osseointegrated Bone-Anchored Limb Outcomes NCT07263945 | University of Colorado, Denver | Phase 1 |
| Recruiting | A Unique Body-Powered Terminal Device With Enhanced Grasping Capabilities for Individuals With Upper Limb Loss NCT07254247 | Little Room Innovations, LLC | N/A |
| Recruiting | A Comparison of Myoelectric and Bionic Hands NCT07347561 | Gulhane School of Medicine | — |
| Recruiting | Operative Treatment vs Treatment With Semi-occlusive Dressing for Single Finger Amputations NCT07175675 | Tampere University Hospital | N/A |
| Recruiting | Effects of Myoelectric Channel Count and Targeting for Upper Limb Prosthetic Control NCT07011420 | Liberating Technologies, Inc. | N/A |
| Completed | The Investigations of Core Muscles, Gait, Balance and Proprioception in Transtibial Amputees NCT07203235 | sevilay seda bas | — |
| Active Not Recruiting | Analgesic Amputation for Algodystrophy: Feedback From a Case Series NCT07364266 | University Hospital, Brest | — |
| Completed | Satisfaction and Quality of Life Among Prosthetic Users in Gaza Governorate , NCT07519746 | Yeditepe University | — |
| Completed | Turkish Validation and Reliability of the John Hopkins In-Room Independence Scale NCT07250243 | Sisli Hamidiye Etfal Training and Research Hospital | — |
| Recruiting | Effects of Microprocessor-controlled Prosthetic Knees on Fall-related Health Outcomes in Limited Community Amb NCT06937242 | Hanger Institute for Clinical Research and Education, LLC | N/A |
| Recruiting | Prosthetic Performance Enhancement Trial NCT06419920 | University of Nevada, Las Vegas | N/A |
| Recruiting | Efficacy and Mechanisms of Virtual Reality Treatment of Phantom Leg Pain.Home-Based Treatment NCT07044323 | Albert Einstein Healthcare Network | N/A |
| Not Yet Recruiting | Investigation of Embodiment for Upper Limb Amputees NCT04578327 | VA Office of Research and Development | N/A |
| Not Yet Recruiting | 3-Dimensional Evaluation of Body Perception NCT06985329 | Trakya University | — |
| Recruiting | Quantification of Motor Compensation Following Biomechanical, Proprioceptive and Physiological Alterations Pos NCT06780943 | Centre Hospitalier Universitaire de Nīmes | — |
| Not Yet Recruiting | New Rear Anti-tip Device for Manual Wheelchairs: Subjective Input (RAD-SI) NCT06831240 | Nova Scotia Health Authority | — |
| Recruiting | Cryo NerVe Block Extremity AmputatioN RegIStry for Post Operative and pHantom Limb Pain NCT06908538 | AtriCure, Inc. | — |
| Unknown | The Relationship Between Trunk Position Sense and Muscle Activation, Balance and Quality of Life in Amputees NCT06046300 | Hacettepe University | — |
| Recruiting | Regenerative Peripheral Nerve Interface for Control of Lower Limb Prostheses NCT06275282 | University of Michigan | N/A |
| Not Yet Recruiting | Effect of Music During Toe Amputation NCT06776809 | Afyonkarahisar Health Sciences University | N/A |
| Active Not Recruiting | Chronic Pain and Amputation: A Quality of Life Comparison NCT06704386 | Kastamonu University | — |
| Recruiting | Promoting Physical Activity Following Dysvascular Amputation NCT06667739 | West Park Healthcare Centre | N/A |
| Completed | Our Emergency Fasciotomy and Amputation Experiences NCT06764446 | Ankara City Hospital Bilkent | — |
| Recruiting | Detecting Change in Muscle Parameters, Pain, and Function With NMES for TTA NCT06830876 | Sara Peterson-Snyder | N/A |
| Terminated | Investigation on a New Power Knee Firmware Update on Gait and Daily Life Activities for Transfemoral Amputees NCT06620861 | Össur Iceland ehf | N/A |
| Recruiting | Regulatory Clearance of the Glide Control Strategy for Upper Limb Prostheses NCT06539936 | Infinite Biomedical Technologies | N/A |
| Completed | Sagittal Knee Kinematics of Transtibial Amputee with Running Blade NCT06586762 | Baskent University | — |
| Completed | Extremity Thermographic Values in Individuals With Transtibial Amputation NCT06258343 | Baskent University | — |
| Active Not Recruiting | Effect of PNF-Based Upper Extremity Strengthening With Core Stabilization on Fitness in Amputee Football Playe NCT06556082 | Uskudar University | N/A |
| Enrolling By Invitation | Thermoregulation in Individuals With a Leg Amputation NCT06458426 | University of Utah | N/A |
| Active Not Recruiting | Magnetic Bead Tracking System and eOPRA Implant System With Bionic Prosthesis for Transtibial Amputees NCT06391697 | Brigham and Women's Hospital | N/A |
| Recruiting | Passive Microprocessor-controlled Knees vs. Active Microprocessor-controlled Knees After Transfemoral Amputati NCT06406491 | Median | — |
| Recruiting | Studies Into Touch in Healthy Humans to Provide Sensory Feedback in Prostheses NCT05548322 | Institut National de la Santé Et de la Recherche Médicale, France | N/A |
| Recruiting | Usability of the Smart Hallway System in Clinical Setting NCT06645054 | University Rehabilitation Institute, Republic of Slovenia | — |
| Completed | Biomechanical Evaluation of a Novel, Compliant Low Profile Prosthetic Foot NCT06468059 | Little Room Innovations, LLC | N/A |
| Completed | Somatosensation Device Trial NCT06168396 | Shirley Ryan AbilityLab | N/A |
| Unknown | Comparing Wound Complication Following TMA With Aid of Electrospun Fiber Matrix NCT06063694 | Scripps Health | N/A |
| Recruiting | A Prosthetic Foot Test-Drive Strategy for Improving Stability in Veterans With Leg Amputations NCT05473065 | Seattle Institute for Biomedical and Clinical Research | N/A |
| Active Not Recruiting | Development And Durability Of Prosthetic Liner For Transtibial Amputee NCT06762847 | Superior University | — |
| Completed | Clinical Investigation (Beta) of a New Developed Prosthetic Knee NCT06748729 | Össur Iceland ehf | N/A |
| Unknown | Evaluation of Functionality of Amputees According to the Medicare Functional K Classification System NCT06293443 | Medipol University | N/A |
| Recruiting | Study of Efficacy of the MyoTrain System in a Population of Individuals With Trans-radial Limb Loss NCT05888428 | Infinite Biomedical Technologies | N/A |
| Completed | The Knowledge Gaps of Amputee Rehabilitation Course Content in Physiotherapy Curriculum NCT06569979 | Akdeniz University | — |
| Completed | Gait Parameters in a Cohort of Patients Fitted With a Canadian Prosthesis: Contribution of Quantified Gait Ana NCT06994741 | Institut Robert Merle d'aubigné | — |
| Recruiting | Pro APP Prosthetic Outcome Registry NCT06210620 | Össur Iceland ehf | — |
| Recruiting | Powered Prosthesis for Use With TF Osseointegration Recipients NCT06160882 | Shirley Ryan AbilityLab | N/A |
| Recruiting | Deploying Digital Prosthetic Interface Technology and Exercise in Dysvascular Amputees NCT05656924 | Spaulding Rehabilitation Hospital | Phase 2 |
| Recruiting | TITAN Trial: Reducing Phantom Limb Pain in People with Amputations NCT06167330 | Neuroscience Research Australia | N/A |
| Recruiting | Controlling Locomotion Over Continuously Varying Activities for Agile Powered Prosthetic Legs NCT06138977 | University of Michigan | N/A |
| Unknown | Comparative Study Evaluating the Mobility of Transtibial Amputee Patients Using the PRO-FLEX PIVOT® Foot Versu NCT06627361 | Össur Iceland ehf | N/A |
| Completed | RESCU System for Robust Upper Limb Prosthesis Control NCT04043234 | Infinite Biomedical Technologies | — |
| Enrolling By Invitation | Sonomyographic Upper Limb Prosthetics: A New Paradigm NCT05376332 | George Mason University | N/A |
| Not Yet Recruiting | Downstream Effects of Personalized 'Top-down' Participation-based Interventions Among Youth With Physical Disa NCT05784285 | McGill University | N/A |
| Completed | Assessing the Usability and Reliability of the Prototype Prosthesis Devices NCT06616402 | Fondazione Don Carlo Gnocchi Onlus | N/A |
| Unknown | A Patient-Driven Augmented Reality-Based Rehabilitation System to Improve Upper Limb Amputee Outcomes NCT05975970 | Infinite Biomedical Technologies | N/A |
| Recruiting | Clinical Outcomes With Non-Powered vs. Powered Prosthetic Knees by K2-level Amputees NCT06194838 | Liberating Technologies, Inc. | N/A |
| Recruiting | Impact of Improving Footwear Options NCT05601869 | VA Office of Research and Development | N/A |
| Completed | The Relationship of Quadriceps and Hamstring Strength on Timed up and go Scores in Transtibial Amputees NCT07067203 | Cairo University | N/A |
| Recruiting | Effectiveness of Frontal Plane Adaptability in a Novel Foot Prosthesis NCT06214026 | University of Washington | N/A |
| Completed | Intent Recognition for Prosthesis Control NCT05537792 | Georgia Institute of Technology | N/A |
| Unknown | Examining Capacity Building of Youth With Physical Disabilities to Pursue Participation Following the PREP Int NCT06007885 | McGill University | N/A |
| Completed | Comparison of Characteristics Between Faller and Non-faller Transtibial Amputees NCT05999539 | Eastern Mediterranean University | — |
| Active Not Recruiting | Development and Usability of an Adjustable Prosthesis for Aquatic Therapy NCT06259695 | Shirley Ryan AbilityLab | N/A |
| Completed | Assessing the DSR Ankle NCT05955378 | Synchro Motion LLC | N/A |
| Unknown | Vibrotactile Stimulation With Saphenus Device NCT05961072 | Massachusetts General Hospital | N/A |
| Completed | A Sensorimotor Prosthesis for the Upper Limb NCT05220553 | University Hospitals Coventry and Warwickshire NHS Trust | N/A |
| Recruiting | Enhancing Motor Function in Individuals with Lower Limb Amputation NCT06638723 | University of Nevada, Las Vegas | N/A |
| Completed | Biomechanical Study of Different Prostheses for Unilateral Transtibial Amputees During Indoor and Outdoor Acti NCT06390033 | The Hong Kong Polytechnic University | — |
| Completed | Psychosocial Transitional Group Pragmatic Trial NCT05798091 | Sunnybrook Health Sciences Centre | N/A |
| Completed | Aerofit Post Market Investigation NCT05925712 | Össur Iceland ehf | N/A |
| Recruiting | PO vs IV Antibiotics for the Treatment of Infected Nonunion of Fractures After Fixation NCT05699174 | Major Extremity Trauma Research Consortium | Phase 3 |
| Unknown | Toe Amputations in Patients With Diabetes NCT05855980 | Tampere University Hospital | N/A |
| Unknown | Psychometric Qualities IPAQ-SF NCT05989113 | FondationbHopale | — |
| Recruiting | Understanding How Powered Componentry Impacts K2-Level Transfemoral Amputee Gait NCT06433648 | Shirley Ryan AbilityLab | N/A |
| Unknown | Targeted Muscle Reinnervation Study (TMR) NCT05408520 | Joshua Hustedt | N/A |
| Completed | Digital Weight Bearing Shape Capture Socket Technology NCT05749952 | Indiana University | N/A |
| Withdrawn | Effect of Prophylactic TMR and RPNI on Neuroma and Phantom Limb Pain NCT05344261 | University of Texas Southwestern Medical Center | N/A |
| Completed | The Dynamic Postural Changes in Transtibial and Transfemoral Amputees NCT05301270 | Hacettepe University | — |
| Completed | Nutrition in People With a Lower Limb Amputation NCT05747066 | University Medical Center Groningen | — |
| Completed | Crossing the Divide: Piloting Integrated Care to Reduce Amputations Among Rural Patients With Diabetic Foot Ul NCT05203471 | University of Wisconsin, Madison | N/A |
| Completed | Phantom Limb Pain in Amputees After the 2023 Türkiye Earthquake NCT06617728 | Mesut Bakır | — |
| Unknown | Walking Characteristics of Patients With Amputation NCT05595291 | Gaziler Physical Medicine and Rehabilitation Education and Research Hospital | — |
| Unknown | Vascular Amputee Physical Performance Qualitative (VAmPP-Q) Study NCT05860764 | University of Leicester | — |
| Active Not Recruiting | Transfemoral Osseointegrated Prosthesis Limb-Load Symmetry Training NCT05695911 | University of Colorado, Denver | N/A |
| Unknown | MetaMet: Bone Cutter Versus Bone Saw for Ray Amputation NCT05804565 | University College Hospital Galway | N/A |
| Recruiting | Clinical Feasibility of the IMES Transradial Prosthesis NCT04936789 | Össur Iceland ehf | N/A |
| Withdrawn | Evaluation of Dexterous Terminal Device NCT05840601 | Liberating Technologies, Inc. | N/A |
| Completed | Economic Evaluation of Lower Limb Prostheses for Persons With a Knee-disarticulation or Transfemoral Amputatio NCT06105944 | University Medical Center Groningen | — |
| Completed | Intervention on Bone Health in Wheelchair Users NCT05615402 | Norwegian School of Sport Sciences | N/A |
| Unknown | Virtual Reality in the Rehabilitation in Patients With Lower Limb Amputation. NCT05773560 | University Hospital Erlangen | N/A |
| Completed | 1C70 Feasibility Study NCT05628064 | Otto Bock Healthcare Products GmbH | N/A |
| Unknown | Study of Lower-limb Phantom Pain Syndrome Using Peripheral Nerve and Spinal Cord Stimulation NCT05807607 | Artur Biktimirov | N/A |
| Completed | COMPARISON OF THE EFFECTS OF TELEREHABILITATION AND FACE-TO-FACE SPINAL STABILIZATION TRAININGS ON GAIT BIOMEC NCT05569967 | Ankara Yildirim Beyazıt University | N/A |
| Recruiting | Self-Management for Amputee Rehabilitation Using Technology. NCT04953364 | University of British Columbia | N/A |
| Active Not Recruiting | Pneumatic Tourniquet Versus no Tourniquet in Transfemoral Amputation NCT05550623 | University of Southern Denmark | N/A |
| Active Not Recruiting | Optimizing Prosthetic Prescription to Mitigate the Effects of Perspiration NCT07024342 | VA Puget Sound Health Care System | N/A |
| Unknown | Evaluation of Satisfaction and Effect on Daily Living Activities With the Use of Myoelectric Controlled Prosth NCT05261178 | Gaziler Physical Medicine and Rehabilitation Education and Research Hospital | — |
| Recruiting | Multicenter Trial Evaluating the Safety and Efficacy of Autologous Volar Fibroblast Injection Into the Termina NCT04839497 | Major Extremity Trauma Research Consortium | Phase 2 |
| Completed | Comparison of Joint Position Sense in Diabetic and Traumatic Transtibial Amputees NCT05542901 | Recep Tayyip Erdogan University Training and Research Hospital | N/A |
| Terminated | Liposomal Bupivacaine vs Continuous Nerve Catheters for Below the Knee Amputations NCT05140499 | Aurora Quaye | Phase 4 |
| Completed | An Investigation on Function and Performance of a New Microprocessor Controlled Prosthetic Knee NCT05523349 | Össur Iceland ehf | N/A |
| Unknown | Diabetic Foot Care and Limb Preservation Pathway: Developmental Evaluation Study NCT05446337 | University Health Network, Toronto | — |
| Withdrawn | An Uneven Terrain Surface to Improve Locomotor Robustness in People With Amputation NCT05560061 | University of Nevada, Las Vegas | N/A |
| Completed | The Effect of Ischemic Conditioning on Strength and Ambulation in Subjects with PAD NCT04937179 | University of Illinois at Chicago | N/A |
| Completed | The Pain in Amputees Reduced by Administration of Diet Examination NCT05460845 | University of Alabama at Birmingham | N/A |
| Recruiting | MultiSENSory Stimulation to TArgeT Sensory Loss and ChronIc Pain in NeurOpathic PatieNts NCT05483816 | ETH Zurich | N/A |
| Unknown | Comparing Intact and Residual Amputated Muscle NCT06182202 | North Carolina State University | N/A |
| Completed | Comorbidity Screening and Referral by Prosthetists NCT05410548 | University of Delaware | N/A |
| Completed | The Effects of Targeted Phantom Motor Execution on Phantom Limb Control NCT05247827 | University of Saskatchewan | N/A |
| Completed | Targeted Sensory Reinnervation (TSR) in Hand Amputation NCT06249594 | Brixsana Private Clinic - Centro di Chirurgia Plastica, Estetica ed Ricostruttiva con Chirurgia dell | — |
| Completed | Clinical Outcomes With Passive MPKs vs. Powered Prosthetic Knees NCT05267639 | Liberating Technologies, Inc. | N/A |
| Completed | Sitting Balance in Lower Limb Amputees NCT05597696 | Hacettepe University | — |
| Withdrawn | Patterned Electric Dressing Effects on Open Wounds NCT04018469 | Gayle Gordillo | — |
| Terminated | Neuromodulation in Lower Limb Amputees NCT04543786 | University of Pittsburgh | N/A |
| Active Not Recruiting | Tolerability and Feasibility Pilot Clinical Study of a Large-Diameter Nerve Cap for Protecting and Preserving NCT04865679 | Axogen Corporation | N/A |
| Completed | Evaluating User Satisfaction and Feasibility of a Remote Model for 3d Scanned and Printed Transtibial Prosthet NCT06361966 | Tan Tock Seng Hospital | N/A |
| Unknown | Effectiveness of the Autologous Adipose Tissue Harvested With SEFFICARE Method for Treatment of DFU Minor Ampu NCT05072353 | Azienda Ospedaliero-Universitaria di Modena | N/A |
| Completed | Dual-tasking for Individuals With Lower Limb Amputation: Exploring the Relationship to Falls and Instrumental NCT05119192 | VA Office of Research and Development | — |
| Completed | Post Market Clinical Protocol - Xtremity Polymer Prosthetic Socket System NCT05190354 | Medical Creations, Inc. | N/A |
| Completed | Limb Health and Socket Pressure in Response to Powered Ankle Protheses NCT05112679 | Indiana University | N/A |
| Completed | Socket Geometry and Clinical Outcomes of Manual vs Digital Sockets for Lower-limb Amputees NCT06504303 | West Park Healthcare Centre | N/A |
| Unknown | Osseointegrated Transtibial Prosthesis With Neural Interface NCT05249049 | Massachusetts Institute of Technology | N/A |
| Active Not Recruiting | The Effect of Negative Pressure Wound Therapy on Wound Healing in Major Amputations of the Lower Limb NCT04618406 | University of Southern Denmark | N/A |
| Completed | Effect of Femoral and Sciatic Nerve Blocks, Combined with General Anesthesia, in Postoperative Pain Levels and NCT06693427 | DIMITRIOS KATSAROS | — |
| Unknown | Study of Phantom Limb Pain Using Peripheral Nerve and Spinal Cord Stimulation NCT05650931 | Artur Biktimirov | N/A |
| Completed | Using a Psychosocial Transitional Group to Improve Adaptation, Coping and Mental Health Outcomes Following Lim NCT05082870 | Sunnybrook Health Sciences Centre | N/A |
| Completed | Evaluation of Individuals with Partial or Finger Amputation After Silicone Prosthesis Use NCT06874582 | Medipol University | N/A |
| Completed | Weight-bearing Exercise for Trans-tibial Amputees NCT05095805 | University Rehabilitation Institute, Republic of Slovenia | N/A |
| Active Not Recruiting | Acceptability of an Interim Socket System NCT05196100 | University of Hull | N/A |
| Active Not Recruiting | Does Increasing Oxygen Nurture Your Symptomatic Ischemic Ulcer Sufficiently? NCT05804097 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Phase 4 |
| Unknown | Biomechanical Assessment of Load Applied on Residuum of Individuals With Limb Loss Fitted With a Prosthetic Li NCT05870267 | YourResearchProject Pty Ltd | — |
| Completed | Qbrexza Cloths for Hyperhidrosis of Amputation Sites NCT04924036 | University of Utah | Phase 2 |
| Completed | Kinetic Analysis Due to Foot Dysfunction NCT05161364 | Delta University for Science and Technology | — |
| Completed | Physical Activity and Sports for People With Special Needs NCT05778799 | Józef Piłsudski University of Physical Education | — |
| Terminated | Sciatic Block in Contralateral Limb Phantom and Residual Limb Pain NCT05046639 | Northwestern University | Phase 4 |
| Unknown | Telerehabilitation in Individuals With Unilateral Transtibial Amputation NCT04968691 | Mehmet Kurtaran | N/A |
| Completed | Dexterous Partial Hand Prosthesis Outcomes NCT05038566 | Liberating Technologies, Inc. | N/A |
| Unknown | The Effect of Different Microprocessor Knee Prostheses on Mobility and Gait Parameters in Transfemoral Amputee NCT04966936 | Gaziler Physical Medicine and Rehabilitation Education and Research Hospital | — |
| Completed | Predictors of Foot Amputation in Diabetic Foot Ulcers NCT05551988 | Bolan Medical Complex Hospital Quetta Pakistan | — |
| Recruiting | Effectiveness and Cost-effectiveness of Lower Limb Prostheses NCT06031922 | University Medical Center Groningen | — |
| Completed | Metabolic Cost of Walking With Passive vs. Powered Microprocessor Controlled Knees NCT05048355 | Össur Iceland ehf | N/A |
| Terminated | Moisture Management Liner At-Home Evaluation NCT05124873 | Liberating Technologies, Inc. | N/A |
| Unknown | Early Evaluation of the Introduction of Pre- and Post-operative Psychological and Physiotherapeutic Follow-up NCT04750876 | Centre Hospitalier Departemental Vendee | N/A |
| Completed | Effectiveness of Supervised Training Program on Mobility and Balance Confidence in Individual With Lower Limb NCT05180682 | NCS University System | N/A |
| Completed | Kinesiophobia and Associated Factors in Patients With Traumatic Lower Extremity Amputation NCT04775667 | Gaziler Physical Medicine and Rehabilitation Education and Research Hospital | — |
| Terminated | Revofit™ System Evaluation on Residual Limb Pain in Amputee Patients NCT04276714 | University Hospital, Angers | N/A |
| Completed | The Effect of Using Two Different Prosthetic Feet in Patients With Unilateral Transtibial Amputation NCT04759014 | Gaziler Physical Medicine and Rehabilitation Education and Research Hospital | — |
| Completed | Basic Mobility and Balance Performance of Low Active Transfemoral Prosthesis Users With a Powered Prosthetic K NCT04799145 | Össur Iceland ehf | — |
| Unknown | A Comprehensive Evaluation of a the Talaris Demonstrator NCT04599530 | Vrije Universiteit Brussel | N/A |
| Terminated | Mechanisms and Treatment of Post-amputation Neuropathic Pain NCT04819503 | Oslo University Hospital | N/A |
| Terminated | Patient Reported Outcomes Following Targeted Muscle Reinnervation NCT04658368 | University of Wisconsin, Madison | — |
| Recruiting | Can an Array of Micro-electrodes Implanted in a Human Nerve Record Neural Signals and Provide Feedback? NCT05505513 | University of Utah | N/A |
| Withdrawn | Sensory Responses to Dorsal Root Stimulation NCT04725006 | Lee Fisher, PhD | — |
| Recruiting | Evaluating the Experience of Upper Limb Prosthesis Use NCT04855214 | Louis Stokes VA Medical Center | — |
| Completed | Upper Limb Loss Perturbation Response NCT04274218 | VA Office of Research and Development | N/A |
| Completed | Lower Limb Prostheses for Individuals Who Carry Infants, Toddlers, and Other Loads NCT07159490 | VA Puget Sound Health Care System | N/A |
| Unknown | Effectiveness of a Peer Visitation Program to Improve Patient Activation and Quality of Life During Amputation NCT03326115 | Prosthetic Design & Research | N/A |
| Completed | Forensic-medical Aspects of Lower Limb Prosthetics: An Observational Study NCT05392907 | Istituto Nazionale Assicurazione contro gli Infortuni sul Lavoro | — |
| Unknown | Safety and Effectiveness of Electronically Controlled Prosthetic Ankle NCT04630457 | Veterans Health Service Medical Center, Seoul, Korea | N/A |
| Completed | The PERCEIVE Study NCT04903756 | Aneurin Bevan University Health Board | — |
| Active Not Recruiting | VR to Evaluate Phantom Limb Pain NCT05915065 | Shirley Ryan AbilityLab | N/A |
| Completed | Daily Socket Comfort in Transtibial Amputee With an Active Vacuum Suspension System NCT04804150 | Össur Iceland ehf | N/A |
| Completed | No Power Bionic Lower Extremity Prosthesis NCT04070105 | University of Michigan | N/A |
| Completed | Pattern and Type of Amputation and Mortality Rate Associated With Diabetic Foot in Jeddah, Saudi Arabia: A Ret NCT05123157 | King Abdulaziz University | — |
| Recruiting | Target Muscle Re-innervation and Regenerative Peripheral Nerve Interfaces Alone and in Combination for the Tre NCT06840262 | M.D. Anderson Cancer Center | N/A |
| Completed | Connect TF - An Investigation of Function and Usability of a New Adaptable Socket System NCT04388488 | Össur Iceland ehf | N/A |
| Unknown | The CLI-AMP Registry NCT04427124 | Hendrick Medical Center | — |
| Completed | Study on the Functionality, Safety and Reliability of a Robotic Prosthesis for the Lower Limb At the Transfemo NCT06284005 | Fondazione Don Carlo Gnocchi Onlus | N/A |
| Completed | Interventional Study on the Evaluation of Functionality, Safety of a Robotic Prosthesis for Transtibial Amputa NCT06161961 | Fondazione Don Carlo Gnocchi Onlus | N/A |
| Completed | Kerecis Omega3 Wound Plus SOC vs. SOC Alone in Treating Severe Diabetic Foot Ulcers and Forefoot Amputations NCT04257370 | Kerecis Ltd. | N/A |
| Unknown | Vibro-tactile Pressure Feedback of the Prosthetic Foot for Trans-tibial Amputees NCT03965663 | Agnes Sturma | N/A |
| Completed | Moisture Management Liner Effectiveness Study NCT04427007 | Liberating Technologies, Inc. | N/A |
| Completed | Statistical Parametric Mapping (SPM 1D) for Stroke and Trans-tibial Amputation NCT04169594 | Tan Tock Seng Hospital | — |
| Completed | Shared Decision Making Aid for Prosthetic Design NCT04536025 | University of Colorado, Denver | — |
| Unknown | Clinical Trial Comparing Negative Pressure Wound Therapy and Standard Dry Dressings NCT04520841 | University of Lausanne Hospitals | N/A |
| Completed | Mechanical Determinants of Upper Limbs Oscillation During Gait NCT05778474 | Istituto Auxologico Italiano | — |
| Active Not Recruiting | Personalized Mobility Interventions Using Smart Sensor Resources for Lower-Limb Prosthesis Users NCT03930199 | Shirley Ryan AbilityLab | N/A |
| Terminated | Use of Long-acting Bupivacaine In Lower Extremity Amputation NCT04360421 | Loma Linda University | Phase 4 |
| Active Not Recruiting | GaMA Metric to Quantify Functional Importance of Various Upper Limb Prosthetic Devices NCT06420687 | Shirley Ryan AbilityLab | N/A |
| Completed | Assessment of a Hybrid Pump for Vacuum Suspension of Prosthetic Sockets for Persons With Lower Limb Loss to Ch NCT04230512 | VA Office of Research and Development | N/A |
| Unknown | Development of the ICF Based Amputee Mobility Scale NCT04276467 | Hacettepe University | — |
| Unknown | Enhanced Auto-Diagnostic Adaptive Precision Trainer for Myoelectric Prosthetic Users NCT04238533 | University of South Florida | N/A |
| Completed | Telehealth Pain Self-Management for Employed Adults NCT04248725 | University of Washington | N/A |
| Terminated | Pain After Proximal Digital Amputation Prevention NCT04378062 | Indiana University | N/A |
| Recruiting | AMI Construction in Lower Extremity Residual Limbs NCT04063592 | Brigham and Women's Hospital | N/A |
| Unknown | Comparison of Dual Task Gait Characteristics in Individuals With Amputation and Healty Individuals NCT04392466 | Hacettepe University | — |
| Recruiting | Efficacy of Split Gait in the Treatment of Dynamic Asymmetries in Subjects With Pathologic Claudication NCT04635436 | Istituto Auxologico Italiano | N/A |
| Withdrawn | An Osseoanchored Percutaneous Prosthesis Study Evaluating Stable Neural Signal Transmission in Subjects With T NCT03957226 | University of Michigan | N/A |
| Withdrawn | Transtibial Pin Lock Suspension at Varying Distraction Values Using a Modified Air Bladder Casting System NCT04248907 | Loma Linda University | N/A |
| Completed | Active Isolated Stretch and Post Facilitation Stretch on Hamstring Flexibility in Trans-tibial Amputees. NCT04588753 | Riphah International University | N/A |
| Completed | Validity and Reliability of the Community Integration Questionnaire-Revised in Lower Limb Amputees NCT05706818 | Hacettepe University | — |
| Completed | Clinical Investigation (Beta) of Power Knee Mainstream - Dynamic NCT04787627 | Össur Iceland ehf | N/A |
| Completed | Functional Outcomes of Voice Recognition Prosthesis NCT04595071 | Liberating Technologies, Inc. | N/A |
| Completed | Dysvascular Amputation Self-Management of Health NCT04083456 | University of Colorado, Denver | Phase 2 |
| Unknown | Motor Learning in Individuals With Lower Limb Loss and Chronic Diabetes NCT03989063 | University of Nevada, Las Vegas | N/A |
| Completed | Transfemoral Socket Design and Muscle Function NCT04212299 | University of Illinois at Chicago | N/A |
| Completed | Understanding Prosthetic Needs and Outcomes in Women Veterans With Amputation NCT03733054 | VA Office of Research and Development | — |
| Recruiting | Autologous Volar Fibroblast Injection Into the Stump Site of Amputees NCT03947450 | Johns Hopkins University | Phase 2 |
| Completed | A Comparative Assessment of Transfemoral Prosthetic Sockets NCT04038580 | University of Michigan | N/A |
| Completed | Effect of Sports-oriented Rehabilitation on Mobility and Daily Activity in People With a Lower-limb Amputation NCT04756752 | Sint Maartenskliniek | — |
| Completed | Socket Cooling Effectiveness Take Home Study NCT04484805 | Liberating Technologies, Inc. | N/A |
| Completed | Does Walking Performance Improve When Veterans With Leg Amputations Are Given Visual Feedback? NCT03974945 | VA Office of Research and Development | — |
| Completed | Robot-assisted Exercise in Patients With Amputation Using Myoelectric Prosthesis NCT04030585 | Istanbul Physical Medicine Rehabilitation Training and Research Hospital | N/A |
| Completed | Comparison of Prosthetic Feet for People With Syme's Amputation (XF Symes Study) NCT04086641 | University of Washington | N/A |
| Completed | Agonist-Antagonist Myoneural Interface for Functional Limb Restoration After Transtibial Amputation NCT03913273 | Massachusetts Institute of Technology | N/A |
| Withdrawn | Evaluating and Improving Assistive Robotic Devices Continuously and in Real-time NCT03632252 | University of Michigan | N/A |
| Recruiting | A Novel Approach to Upper Extremity Amputation to Augment Volitional Control and Restore Proprioception NCT03882073 | Brigham and Women's Hospital | N/A |
| Completed | Myoelectric Game Training and Outcomes NCT04354493 | Liberating Technologies, Inc. | N/A |
| Completed | Optimizing Prosthetic and Bicycle Fit for Veterans With Transtibial Amputations NCT03828331 | VA Office of Research and Development | — |
| Completed | Femoral Cartilage Thickness In Patients With Lower Limb Amputation NCT04422717 | Istanbul Physical Medicine Rehabilitation Training and Research Hospital | — |
| Completed | Evaluation of Closed Incision Negative Pressure Dressing (PREVENA) to Prevent Lower Extremity Amputation Wound NCT03773575 | Thomas Jefferson University | N/A |
| Completed | Evaluation of the Stability of Osseointegrated Implant in Amputees NCT03836755 | Istituto Ortopedico Rizzoli | N/A |
| Terminated | The SNAP Trial: SPRINT® Peripheral Nerve Stimulation for the Treatment of Neuropathic Post-Amputation Pain NCT03783689 | SPR Therapeutics, Inc. | N/A |
| Recruiting | Intuitive Control of a Hybrid Prosthetic Leg During Ambulation NCT04038151 | Shirley Ryan AbilityLab | N/A |
| Completed | A Test-Drive Strategy for the Prescription of Prosthetic Feet for People With Leg Amputations NCT03651830 | Seattle Institute for Biomedical and Clinical Research | N/A |
| Completed | Evaluation of a Microprocessor-controlled Prosthetic Knee-ankle System (SPCM) NCT06522646 | Institution Nationale des Invalides | N/A |
| Completed | Low Cost Socket for Lower Limb Amputees NCT04725461 | Shirley Ryan AbilityLab | N/A |
| Recruiting | Additional Hyperbaric Oxygen After Lower Extremity Amputation NCT03594344 | Oslo University Hospital | N/A |
| Completed | Study of the Value of Using a Honey Dressing Compared to the Use of a Standard Dressing on the Toe Amputation NCT03934281 | Centre Hospitalier Metropole Savoie | N/A |
| Completed | Improving Prosthetic Care for Patients With a Lower Limb Amputation NCT03517774 | Sunnybrook Health Sciences Centre | N/A |
| Completed | Immediate Fit Using Innovative Technology Transtibial & Transfemoral Prosthesis NCT02886936 | University of Pennsylvania | N/A |
| Completed | An Investigation Into a New Manufacture Technique of Trans-femoral Sockets NCT04312724 | Össur Iceland ehf | N/A |
| Completed | Microprocessor Knees in Early Rehabilitation NCT03433300 | University of Washington | N/A |
| Completed | Targeting Balance Confidence to Increase Community Integration in Users of Prostheses NCT03411148 | Rosalind Franklin University of Medicine and Science | N/A |
| Completed | Reduction of Shear Forces Using Semi-flexible Sockets on Transtibial Amputees NCT03390153 | Loma Linda University | N/A |
| Completed | Massage on Pain Levels, Range of Motion, and Muscle Strength in Unilateral Lower Limb Amputees NCT03389334 | Loma Linda University | N/A |
| Completed | A Wheelchair Propulsion Training Program NCT04009187 | Washington University School of Medicine | N/A |
| Completed | Investigation of Rifampin to Reduce Pedal Amputations for Osteomyelitis in Diabetics NCT03012529 | VA Office of Research and Development | Phase 4 |
| Completed | Functional Importance of a Powered Multifunction Wrist Protocol NCT04069793 | Shirley Ryan AbilityLab | N/A |
| Completed | e-OPRA Implant System for Lower Limb Amputees NCT03720171 | Integrum | N/A |
| Unknown | Early Active Finger Exercises in Replanted Fingers NCT03383640 | Oslo University Hospital | N/A |
| Recruiting | Short-term Implanted Electrodes Following Regenerative Peripheral Nerve Surgery for Improving Prosthetic Limb NCT03260400 | University of Michigan | N/A |
| Completed | Postoperative Peripheral Nerve Stimulation for Management of Post-amputation Pain NCT03484429 | Hunter Holmes Mcguire Veteran Affairs Medical Center | N/A |
| Completed | Prosthesis With Sensations NCT03350061 | Clinical Centre of Serbia | N/A |
| Unknown | Evaluating the Outcomes for Incisional Application of Negative Pressure for Nontraumatic Amputations NCT03250442 | Georgetown University | N/A |
| Completed | Comparison of Prosthetic Assessment Tools and Factors Influencing the Outcome NCT03329326 | Medical University of Vienna | — |
| Completed | Virtual Neuroprosthesis: Restoring a Sense of Touch to Amputees NCT03581448 | Florida Atlantic University | N/A |
| Completed | Somatotopic Configuration of Distal Residual Limb Tissues in Lower Extremity Amputations NCT03374319 | Brigham and Women's Hospital | N/A |
| Terminated | Movement and Sensation for Advanced Prosthetic Hands NCT03259386 | Mayo Clinic | — |
| Unknown | Comparison of Prosthetic Feet for the Geriatric Patients(CPF) NCT03249883 | Loewenstein Hospital | N/A |
| Completed | Digital Ankle Brachial Index (ABI) as a Screening Tool in Detecting Peripheral Arterial Disease NCT03161327 | St. Louis University | N/A |
| Completed | EMG-Based Hand-Wrist Control: Study B Mirrored NCT04692571 | Liberating Technologies, Inc. | EARLY_Phase 1 |
| Unknown | The Effects of Dual Task Balance Training In Individuals With Above Knee Amputation NCT03094208 | Hacettepe University | N/A |
| Unknown | Focused Ultrasound Treatment of Stump Neuromas for the Relief of Chronic Post-Amputation Neuropathic Pain NCT03255395 | Rambam Health Care Campus | N/A |
| Completed | Effectiveness of Mirror Therapy in Patients With Amputations of Lower Limbs of Vascular Origin NCT03149432 | Centre d'Investigation Clinique et Technologique 805 | N/A |
| Completed | EmPOWERing Active Seniors With Energy NCT02958553 | Otto Bock Healthcare Products GmbH | N/A |
| Completed | Falls in Older Persons With Limb Loss NCT03670004 | VA Office of Research and Development | — |
| Completed | The Effect of Visual Feedback on Function, Stability and Quality of Life in Transtibial Amputation NCT03316248 | Hacettepe University | N/A |
| Completed | A Clinical and Histological Analysis of Mesenchymal Stem Cells in Amputation NCT02685098 | Indiana University | Phase 1 |
| Withdrawn | Human Penile Tissue Allotransplantation for Devastating Penile and Concomitant Genital Trauma NCT03240822 | Wake Forest University Health Sciences | Phase 1 |
| Unknown | Comparison of Gait Characteristics in Individuals With Above and Below Knee Limb Loss NCT02988310 | Hacettepe University | — |
| Completed | Physical Activity Behavior Change for Older Adults After Dysvascular Amputation NCT02738086 | VA Office of Research and Development | N/A |
| Completed | The Association of Cardiac Valve Calcification and 1-year Mortality After Lower-extremity Amputation in Diabet NCT06079008 | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | — |
| Completed | Prosthetic Socket Interface Design on Socket Comfort, Residual Limb Health, and Function for the Transfemoral NCT02773056 | University of South Florida | N/A |
| Enrolling By Invitation | Prosthetic Limb Movement Feedback for Upper and Lower Extremity Amputees NCT03135847 | The Cleveland Clinic | N/A |
| Completed | Comparative Effectiveness of Microprocessor Controlled and Carbon Fiber Prosthetic Feet in Transtibial Amputee NCT02864693 | Ability Prosthetics and Orthotics, Inc. | N/A |
| Unknown | Evaluation of Correlations Between Different Walk Tests in Patients With Transfemoral Amputees NCT02766387 | University Hospital, Angers | N/A |
| Completed | Functional Performance Evaluation of NU-FlexSIV Socket NCT02678247 | Northwestern University | N/A |
| Completed | Post-amputation Survival Following Rehabilitation Medium and Long-term Follow up Study, a Retrospective Analys NCT03539120 | Changi General Hospital | — |
| Recruiting | Feasibility of Neural Feedback for Lower Limb Amputees NCT03409133 | Louis Stokes VA Medical Center | N/A |
| Completed | An Investigation of Functional Improvements in the RHEO KNEE Compared to Hydraulic Microprocessor Controlled K NCT04023578 | Össur Iceland ehf | N/A |
| Recruiting | Hand Transplantation NCT02476838 | NYU Langone Health | N/A |
| Unknown | Kinematic, Kinetic, and Metabolic Comparison of Bilateral Transfemoral Ambulation With Passive Versus Powered NCT02366702 | Southern California Institute for Research and Education | — |
| Completed | Adaptive Recalibration of Prosthetic Leg Neural Control System NCT02355912 | Shirley Ryan AbilityLab | N/A |
| Completed | HRQoL Among Patients Amputated Due to Peripheral Arterial Disease NCT03570788 | Jonas Malmstedt | — |
| Completed | Implantable MyoElectric Sensors (IMES) for Prosthetic Control in Transhumeral Amputees NCT03644394 | Medical University of Vienna | N/A |
| Withdrawn | Investigation of the Use of Hyperspectral Imaging in Foot Surgery Patients NCT03787862 | University of Texas Southwestern Medical Center | — |
| Recruiting | Human Penile Allotransplantation NCT02395497 | Johns Hopkins University | Phase 2 / Phase 3 |
| Completed | AMP30: Autologous Fat Grafting, Amputation Sites Pain: Randomized NCT02076022 | J. Peter Rubin, MD | N/A |
| Completed | Validation of the SIGAM/VF Mobility Grade NCT02859740 | Centre Hospitalier Universitaire Dijon | — |
| Completed | Comparison of Pattern Recognition Control and Direct Control in TMR NCT03097978 | Shirley Ryan AbilityLab | N/A |
| Completed | Measures of Gait Efficiency of Three Multi-Axial, Vertical Shock and Energy Storing-Return Prosthetic Feet Dur NCT01404559 | University of South Florida | N/A |
| Completed | Effect of Socket Wall Height With Vacuum Suspension for Above Knee Amputees NCT01559909 | Stony Brook University | Phase 1 |
| Withdrawn | Genetics and Phantom Limb Pain NCT01517061 | National Institute of Nursing Research (NINR) | — |
| Unknown | Evaluation of a Pro-Active Dynamic Accommodating Socket NCT01546311 | Infoscitex Corporation | — |
| Unknown | Dynamic Management of Excess Residual Limb Pressure With New Smart Socket Technology/Intelligent Prosthetic So NCT01108536 | University of Wisconsin, Milwaukee | N/A |
| Completed | Clinical Evaluation of Direct Manufactured Prosthetic Sockets NCT01155024 | Ohio Willow Wood | Phase 2 |
| Completed | Amputee Residual Limb Volume Fluctuation NCT01161238 | University of Washington | — |
| Unknown | Stability and 3D Motion Study of an Experimental Prosthetic Foot NCT00968292 | Tensegrity Prosthetics | Phase 3 |
| Completed | A Client-Based Outcome System for Individuals With Lower Limb Amputation NCT01750372 | University of Washington | — |
| Unknown | Clinical Trial of Tensegrity Prosthetics K3 Promoter Foot Prosthesis NCT00888199 | Tensegrity Prosthetics | Phase 2 / Phase 3 |
| Completed | Study to Determine if Different Prosthetic Sockets Effect How Much Oxygen is in the Tissue of Lower Limb Amput NCT00985842 | VA Office of Research and Development | N/A |
| Completed | Telephone Intervention for Pain Study (TIPS) NCT00663663 | University of Washington | N/A |
| Unknown | Pathology of Skin, Nerve and Vasculature in the Amputated Limb of Diabetes NCT00840164 | National Taiwan University Hospital | — |
| Terminated | Naval Medical Center San Diego (NMCSD) - Ambulatory Continuous Peripheral Nerve Blocks for Treatment of Post-A NCT00768248 | University of California, San Diego | N/A |
| Completed | Ambulatory Continuous Peripheral Nerve Blocks for Treatment of Post-Amputation Phantom Limb and Stump Pain NCT00667264 | University of California, San Diego | N/A |