NCT06908538

Cryo NerVe Block Extremity AmputatioN RegIStry for Post Operative and pHantom Limb Pain

Cryo NerVe Block Extremity AmputatioN RegIStry for Post Operative and pHantom Limb Pain (VANISH)

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 2,000 (estimated)
• Sponsor: AtriCure, Inc. · Industry
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The goal of this Registry is to see how the device is used when freezing nerves during an amputation procedure.

Conditions

• Amputation
• Amputation of Lower Limb
• Amputation of Upper Limb
• Amputation, Limb Loss
• Amputation, Traumatic/Surgery
• Cryo Analgesia

Interventions

Type	Name	Description
DEVICE	cryoablation	Cryoanalgesia, also known as Cryoablation, Cryoneurolysis, or Cryonerve Block, has been used for decades to treat chronic pain and has recently been employed for the management of Phantom Limb Pain. Cryoanalgesia involves the use of a probe to apply extreme cold (approximately -70◦C) to induce reversible axonal injury and Wallerian degeneration to produce a temporary conduction block that is sustained until regeneration of the axon and sensation is restored, typically weeks to months later.

Timeline

• Start date: 2025-04-01
• Primary completion: 2035-04-01
• Completion: 2035-04-01
• First posted: 2025-04-03
• Last updated: 2026-01-07

Locations

4 sites across 1 country: United States

Regulatory

• FDA-regulated device study