| Recruiting | Intervention to Increase Intention to Change Alcohol/Tobacco Use in Veterans With Chronic Disease NCT07039175 | VA Office of Research and Development | Phase 3 |
| Withdrawn | Endourage Complete Spectrum Oral Mucosal Drops (OMD) in Adults Desiring a Reduction in Ethanol Use NCT04659278 | Endourage, LLC | N/A |
| Recruiting | The Potential Therapeutic Effects of Psychedelic, N, N-dimethyltryptamine (DMT), on Alcohol Use Disorder (AUD) NCT06070649 | Yale University | Phase 1 |
| Recruiting | Improving Alcohol and Substance Use Care Access, Outcome, Equity During the Reproductive Years NCT05910580 | Emory University | N/A |
| Recruiting | External Facilitation to Increase Prescribing of AUD Medications in the Psychiatric Setting NCT07053098 | University of Maryland, Baltimore | N/A |
| Recruiting | Comparing Combined Behavioral Intervention and Ericksonian Hypnotherapy for Alcohol Addiction NCT06916754 | Beykoz University | N/A |
| Active Not Recruiting | Addressing Barriers to Care for Substance Use Disorder Trial NCT06729957 | Kaiser Permanente | N/A |
| Recruiting | Diclofenac Dose Response Study NCT06636227 | University of Maryland, Baltimore | Phase 1 |
| Not Yet Recruiting | Phase I, Dose-Escalation Study of Dihydromyricetin (DHM) to Treat Alcohol-Associated Liver Disease NCT05623501 | University of Southern California | Phase 1 |
| Recruiting | Feasibility of the 5-Step Method in the U.S. NCT06565429 | Villanova University | N/A |
| Active Not Recruiting | Addressing Barriers to Care for Substance Use Disorder Pilot Study NCT06317987 | Kaiser Permanente | N/A |
| Recruiting | Centralized Virtual SBIRT for Pediatric Primary Care NCT06486688 | Kaiser Permanente | N/A |
| Completed | Psilocybin in Alcohol Use Disorder With Comorbid Depression NCT06235411 | Centre Hospitalier Universitaire de Nīmes | N/A |
| Completed | Alcohol & Exercise Study NCT05955911 | Western University, Canada | N/A |
| Active Not Recruiting | TeleHealth Resources for IndiVidualizEd Goals (THRIVE) in Alcohol Recovery Study NCT06074341 | University of New Mexico | N/A |
| Recruiting | Project Khanya: Peer-Delivered Intervention to Improve HIV Medication Adherence and Substance Use in South Afr NCT05933226 | University of Maryland, College Park | N/A |
| Recruiting | The Liver Care Trial NCT05855031 | Zealand University Hospital | N/A |
| Withdrawn | Early Detection of Alcoholic Liver Disease NCT04070508 | University of Pittsburgh | — |
| Completed | Common Elements Treatment Approach HIV Alcohol Reduction Trial in Zambia NCT05121064 | University of Alabama at Birmingham | N/A |
| Unknown | Housing for Recovery Initiative NCT05341830 | Adrienne Sabety | N/A |
| Completed | Feasibility and Effects of Activity Trackers Among Alcohol Users Receiving In-patient Treatment for Alcohol Us NCT06629493 | University of Oviedo | N/A |
| Completed | Digital Treatments for Opioids and Other Substance Use Disorders in Primary Care NCT05160233 | Kaiser Permanente | N/A |
| Not Yet Recruiting | Neurobiological Effects of Transcranial Direct Current Stimulation Treatment in Alcohol Use Disorder NCT04897295 | ITAB - Institute for Advanced Biomedical Technologies | N/A |
| Terminated | Feasibility and Potential Effectiveness of a Case Management Intervention for Alcohol Use-Related Problems in NCT04938258 | Hospital Clinic of Barcelona | N/A |
| Suspended | Amplification of Positivity for Alcohol Use Disorder Co-Occurring With Anxiety or Depression NCT04934553 | Charles Taylor | N/A |
| Completed | An Initial Study of the Implementation of Digital Therapeutics for Substance Use Disorders in Primary Care NCT04907045 | Kaiser Permanente | N/A |
| Unknown | VR Assessment for Alcohol Related Brain Damage NCT03826238 | Universitat Pompeu Fabra | — |
| Completed | Substance Use Treatment and Recovery Team (START) NCT04314648 | RAND | N/A |
| Completed | Identifying and Managing Alcohol-related Health Problems in General Practice NCT04725552 | Helse Stavanger HF | N/A |
| Completed | Michigan Alcohol Improvement Network- Alcohol Reduction and Treatment Trial NCT04473482 | University of Michigan | N/A |
| Recruiting | COVID-19 Pandemic Impact on Alcohol (PIA) - A Natural History Study NCT04391816 | National Institute on Alcohol Abuse and Alcoholism (NIAAA) | — |
| Enrolling By Invitation | Cohort/Ethics Study of Patients With Severe Alcoholic Hepatitis Undergoing Early Liver Transplantation NCT04234139 | Johns Hopkins University | — |
| Completed | Neuroimmune Dysfunction in Alcohol Use Disorder NCT04210713 | University of Maryland, Baltimore | Phase 1 |
| Terminated | Effectiveness of a Case Management Intervention for Alcohol Use-Related Problems in Frequent Users of an Emerg NCT04219748 | Hospital Clinic of Barcelona | N/A |
| Terminated | Imaging Biomarker for Addiction Treatment Outcome NCT03427424 | National Institute on Drug Abuse (NIDA) | — |
| Unknown | Messaging Interventions to Reduce Alcohol Problems Project NCT03695653 | Partnership to End Addiction | N/A |
| Completed | Primary Care Treatment Integrating Motivation and Exposure NCT03812146 | Syracuse VA Medical Center | N/A |
| Completed | A Response Modulation Hypothesis of Socioemotional Processing Associated With Alcohol Use Disorder NCT03535129 | National Institute on Alcohol Abuse and Alcoholism (NIAAA) | N/A |
| Completed | Effectiveness & Implementation of a Behavioral Intervention for Adherence and Substance Use in HIV Care in Sou NCT03529409 | University of Maryland, College Park | N/A |
| Completed | Treatment of Asian Flushing Syndrome With Topical Alpha Agonists NCT03497442 | University of California, San Francisco | EARLY_Phase 1 |
| Unknown | Biomarkers of Alcohol After an Experimental Administration of Alcohol Simulating a "Binge Drinking" Episode NCT03931018 | Fundació Institut Germans Trias i Pujol | N/A |
| Completed | Remote Alcohol Monitoring and Episodic Thinking NCT03340051 | Virginia Polytechnic Institute and State University | N/A |
| Recruiting | Recognition and Early Intervention for Alcohol and Substance Abuse in Adolescence in Adolescent NCT06262958 | Kuopio University Hospital | N/A |
| Completed | Addressing the Health Concerns of VA Women With Sexual Trauma NCT02957747 | VISN 17 Center of Excellence | N/A |
| Completed | Melatonin Use for Sleep Problems in Alcohol Dependent Patients NCT03043443 | Centre for Addiction and Mental Health | Phase 2 |
| Completed | Collaborative Care for Alcohol Use Disorders in the Patient-centered Medical Home NCT02885311 | Northwell Health | Phase 1 / Phase 2 |
| Completed | Implementing Screening and Brief Interventions for Excessive Drinkers in Primary Health Care NCT02968186 | Agrupamento de Centros de Saúde de Dão Lafões | N/A |
| Completed | Longitudinal Changes in the Oral and Gut Microbiome of Individuals With Alcohol Dependence NCT02911077 | National Institutes of Health Clinical Center (CC) | — |
| Completed | Interaction of Alcohol With Energy Drinks NCT02771587 | Parc de Salut Mar | Phase 1 |
| Completed | Does Mixing Alcoholic Drinks Make Hangover Worse? NCT03506516 | Zealand University Hospital | N/A |
| Completed | Conflict Between Maternal Autonomy and Child Health in Substance-use NCT02797990 | London School of Hygiene and Tropical Medicine | — |
| Unknown | AlcoChange: An Open Label Pilot Study of Smartphone Monitoring for Alcoholic Liver Disease NCT03474328 | Royal Free Hospital NHS Foundation Trust | N/A |
| Completed | Study of Structural Imaging NCT02564991 | National Institute on Alcohol Abuse and Alcoholism (NIAAA) | — |
| Completed | A Policy Relevant US Trauma Care System Pragmatic Trial for PTSD and Comorbidity NCT02655354 | University of Washington | N/A |
| Completed | Helping College Students With ADHD Lead Healthier Lifestyles NCT02829970 | University of Maryland, College Park | N/A |
| Completed | Laboratory Studies on Oxytocin for Treatment of Alcohol Use Disorder NCT02407340 | Johns Hopkins University | Phase 1 |
| Completed | Adaptive Interventions for Problem Drinkers NCT02511808 | Northwell Health | N/A |
| Completed | A Policy Relevant US Trauma Care System Pragmatic Trial for PTSD and Comorbidity Pilot NCT02335125 | University of Washington | N/A |
| Unknown | Socioeconomic Differences in Alcohol Harm in Finland in a Nationwide Cohort Study NCT05865847 | Finnish Institute for Health and Welfare | — |
| Completed | Mephedrone and Alcohol Interactions in Humans NCT02294266 | Parc de Salut Mar | Phase 1 |
| Completed | The Computer-based Drug and Alcohol Training Assessment in Kenya NCT02388243 | Africa Institute of Mental and Brain Health (AFRIMEB) | N/A |
| Recruiting | Characterization Imaging Instruments in Alcoholics and Non-Alcoholics NCT02108080 | National Institute on Alcohol Abuse and Alcoholism (NIAAA) | — |
| Completed | Tailored Mobile Text Messaging to Reduce Problem Drinking NCT01885312 | Northwell Health | N/A |
| Completed | A Novel Compound for Alcoholism Treatment NCT02039349 | National Institute on Alcohol Abuse and Alcoholism (NIAAA) | Phase 1 |
| Completed | Family Based Prevention of Alcohol and Risky Sex for Older Teens NCT03521115 | Pacific Institute for Research and Evaluation | N/A |
| Completed | Evaluation of an School-based Alcohol Prevention Program for Middle School Students NCT01847183 | Oregon Research Institute | Phase 2 |
| Withdrawn | Computerized Alcohol Screening for Children and Adolescents NCT01539954 | Boston Children's Hospital | — |
| Completed | The Co-Venture Trial: A Cluster Randomized Trial of Personality-targeted Interventions on Adolescent Substance NCT01655615 | St. Justine's Hospital | N/A |
| Completed | Validating NIAAA Screen Guide in YCMC NCT01544218 | Boston Children's Hospital | — |
| Completed | Component Analysis for Motivational Interviewing NCT01642381 | Northwell Health | N/A |
| Terminated | Role of Proinflammatory Signaling in Alcohol Craving NCT01631630 | National Institute on Alcohol Abuse and Alcoholism (NIAAA) | Phase 2 |
| Completed | "Effectiveness of a Brief Intervention for Substances Consumption Linked to the Alcohol, Smoking and Substance NCT01573416 | Pontificia Universidad Catolica de Chile | Phase 3 |
| Completed | Clinical Trial of CBASP for Individuals With Co-occurring Chronic Depression and Alcohol Dependence NCT01528748 | University of Virginia | — |
| Completed | Exercise as Alcohol Use Disorders Intervention for Non-Treatment Seeking Adults NCT01399554 | St. Louis University | Phase 1 |
| Completed | National Epidemiologic Survey on Alcohol and Related Conditions-III NCT01273220 | National Institute on Alcohol Abuse and Alcoholism (NIAAA) | — |
| Completed | Corticotropin-Releasing Hormone Receptor 1 (CRH1) Antagonism in Anxious Alcoholics^ NCT01227980 | National Institute on Alcohol Abuse and Alcoholism (NIAAA) | Phase 2 |
| Completed | Medication-Assisted Treatment Implementation in Community Correctional Environments (MATICCE) NCT01344122 | Rhode Island Hospital | N/A |
| Completed | Couple-Based Treatment for Alcohol Use Disorders and Post-Traumatic Stress Disorder NCT00946322 | VA Office of Research and Development | Phase 1 |
| Unknown | Computer-delivered Psychosocial Intervention for Adolescent Substance Use Disorders NCT00957775 | National Development and Research Institutes, Inc. | N/A |
| Completed | Concurrent Alcohol and Smoking Treatment: Effects on Alcohol Relapse Risk NCT00861146 | Yale University | Phase 2 |
| Completed | Women's Recovery Group (WRG) Study - A Randomized Controlled Stage II Trial NCT01318538 | Mclean Hospital | N/A |
| Completed | Specialized Substance Abuse Supervision (SSAS) Versus Non-SSAS Recidivism Rates Among Nebraska Felony Drug Off NCT00690352 | University of Nebraska | — |
| Completed | Pharmacogenetics of Alcohol: Treatment Implications NCT00734656 | UConn Health | N/A |
| Completed | Evaluation of Case Management to Improve the Outpatient Care of Alcohol-related Disorders NCT00314067 | University Hospital Freiburg | N/A |
| Completed | Medication and Counseling for Controlled Drinking (Project SMART) NCT00444418 | National Institute on Alcohol Abuse and Alcoholism (NIAAA) | Phase 3 |
| Completed | Pharmacokinetic Study of Single Dose Dutasteride in Healthy Subjects NCT00802321 | UConn Health | N/A |
| Completed | Modafinil and Naltrexone to Reduce Cocaine and Alcohol Dependence NCT00142818 | Kyle Kampman | Phase 2 |
| Completed | Effectiveness of Bupropion for Smokers Recovering From Alcohol Dependence NCT00304707 | National Institute on Drug Abuse (NIDA) | Phase 3 |
| Completed | Acamprosate to Reduce Symptoms of Alcohol Withdrawal NCT00106106 | National Institutes of Health Clinical Center (CC) | Phase 2 |
| Completed | Hepatic Function in Alcoholics Following 5 Days of Acetaminophen Dosing NCT00427206 | Denver Health and Hospital Authority | Phase 4 |
| Completed | Alcohol Expert System Intervention for Problematic Alcohol Use NCT00400010 | University of Luebeck | N/A |
| Completed | Placebo Controlled Trial of Depakote ER in Alcohol Dependent Patients With Mood and/or Anxiety Symptoms NCT00202514 | Seattle Institute for Biomedical and Clinical Research | Phase 2 / Phase 3 |
| Unknown | Interactions Between Cocaine and Ethanol and Disulfiram - 1 NCT00094289 | National Institute on Drug Abuse (NIDA) | Phase 1 |
| Completed | Psychosocial and Medication Treatment for Anxiety in Alcoholism NCT00248612 | Boston Medical Center | Phase 2 / Phase 3 |
| Completed | Healthy Living as You Age NCT00379093 | National Institute on Alcohol Abuse and Alcoholism (NIAAA) | Phase 2 |
| Completed | Brief Intervention to Reduce Injury in Minorities NCT00132262 | The University of Texas Health Science Center, Houston | N/A |
| Completed | Naltrexone as Adjunct in Alcoholic Cocaine Dependent Patients - 4 NCT00000307 | National Institute on Drug Abuse (NIDA) | Phase 2 |
| Completed | Naltrexone Treatment of Alcohol Abuse in Schizophrenia NCT00145847 | State University of New York - Upstate Medical University | Phase 4 |
| Completed | The Women's Recovery Group Study: Stage I Trial NCT00230100 | Mclean Hospital | Phase 1 |
| Completed | Hepatic Function During and Following Three Days of Acetaminophen Dosing in Alcoholics NCT00402571 | Denver Health and Hospital Authority | Phase 4 |
| Completed | Stepped Interventions for Problem Drinkers NCT00391742 | University of Luebeck | N/A |
| Completed | Substance Dependent Teens - Impact of Treating Depression Study 1 - 1 NCT00061113 | National Institute on Drug Abuse (NIDA) | Phase 4 |
| Completed | Combination of Disulfiram Plus Naltrexone to Treat Both Cocaine- and Alcohol-dependent Individuals - 1 NCT00142844 | University of Pennsylvania | Phase 2 |
| Completed | Effects of Alcohol History on Effects of Sevoflurane and Nitrous Oxide - 13 NCT00000261 | University of Chicago | Phase 2 |
| Completed | Effects of Alcohol History on Effects of Nitrous Oxide - 9 NCT00000257 | University of Chicago | N/A |
| Completed | Disulfiram for Cocaine-Alcohol Abuse - 3 NCT00000278 | Yale University | Phase 2 |