NCT00061113

Substance Dependent Teens - Impact of Treating Depression Study 1 - 1

Substance Dependent Teens - Impact of Treating Depression Study 1

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 126 (actual)
• Sponsor: National Institute on Drug Abuse (NIDA) · NIH
• Sex: All
• Age: 13 Years – 19 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to evaluate the impact of treating depression on substance dependent teens.

Detailed description

The primary study aim is to determine whether fluoxetine + CBT is a more effective treatment than placebo + CBT for substance outcomes, depression, and behavior problems. The current community standard of care often withholds pharmacotherapy for depression in substance abusing adolescents, since it is often assumed that their depressions may remit with SUD treatment alone. However, this is an untested hypothesis in adolescents and one that we propose to test in the current study.

Conditions

• Alcohol-Related Disorders
• Marijuana Abuse
• Substance-Related Disorders

Interventions

Type	Name	Description
DRUG	Fluoxetine + outpatient cognitive behavioral therapy	single fixed morning dose 20 mg X 15 weeks
DRUG	fluoxetine	20mg, QD x 16 weeks
DRUG	placebo + CBT	single fixed morning dose X 16 weeks

Timeline

• Start date: 2001-02-01
• Primary completion: 2006-08-01
• Completion: 2006-08-01
• First posted: 2003-05-22
• Last updated: 2017-01-12

Locations

2 sites across 1 country: United States