NCT02294266

Mephedrone and Alcohol Interactions in Humans

Mephedrone and Alcohol Interactions After Single-dose Administration in Humans

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 12 (actual)
• Sponsor: Parc de Salut Mar · Academic / Other
• Sex: Male
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

The purposes of this study are 1) to evaluate the pharmacological effects after oral coadministration of mephedrone and alcohol and 2) determine the pharmacokinetics changes of mephedrone and alcohol concentrations after oral coadministration of mephedrone and alcohol.

Detailed description

Mephedrone (4-methylmetcathinone, 4-MMC) is a new psychoactive substance (NPS). Mephedrone is frequently used in combination with alcohol. At present, the effects of the interaction between mephedrone and alcohol in humans have not been previously evaluated in randomized controlled clinical trials. The aims of this study are 1) to evaluate the pharmacological effects after oral coadministration of mephedrone and alcohol and 2) determine the pharmacokinetics changes of mephedrone and alcohol concentrations after oral coadministration of mephedrone and alcohol.

Conditions

• Amphetamine-Related Disorders
• Alcohol-Related Disorders

Interventions

Type	Name	Description
DRUG	Mephedrone and alcohol	Single oral dose mephedrone Single oral dose alcohol
DRUG	Mephedrone	Single oral dose mephedrone
DRUG	Alcohol	Single oral dose alcohol
DRUG	Placebo	Single oral dose placebo

Timeline

• Start date: 2014-12-01
• Primary completion: 2015-03-01
• Completion: 2015-03-01
• First posted: 2014-11-19
• Last updated: 2015-10-08

Locations

1 site across 1 country: Spain