| Recruiting | Human Laboratory Study of Apremilast for Alcohol Use Disorder Alcohol Use Disorder, Alcohol Misuse | Phase 2 | 2026-04-03 |
| Recruiting | Tirzepatide in MetALD Metabolic Alcohol-associated Liver Disease, Alcohol Use Disorder | Phase 2 | 2026-04-01 |
| Recruiting | Role of Metal Ion Transporter ZIP8 in Alcohol-Related Behaviors Healthy Volunteer | Phase 1 | 2025-06-10 |
| Recruiting | Temporally-Resolved Electrophysiology of Acamprosate Treatment of Alcohol Use Disorder Alcohol Use Disorder | Phase 4 | 2025-05-07 |
| Recruiting | Suvorexant for Alcohol Use Disorder (AUD): Neural Mechanisms Healthy Volunteers, Alcohol Use Disorder (AUD) | Phase 1 / Phase 2 | 2024-11-21 |
| Withdrawn | Dopamine Rhythms in Health and Addiction Cocaine Abuse | EARLY_Phase 1 | 2024-04-23 |
| Recruiting | Individual Variations of Taste and Smell Perception in Alcohol Use Disorder (AUD) Alcohol Use Disorder | — | 2024-01-09 |
| Completed | Intranasal Oxytocin for the Treatment of Alcohol Use Disorder Alcohol Use Disorder, Alcohol Misuse | Phase 2 | 2022-06-29 |
| Recruiting | Mechanisms Underlying Individual Variations of Taste and Smell in Obesity Obesity | — | 2022-05-11 |
| Completed | Human Laboratory Study of ASP8062 for Alcohol Use Disorder Alcohol Use Disorder, Alcohol Drinking, Alcohol Use Disorder (AUD) | Phase 2 | 2021-12-13 |
| Recruiting | Safety, Tolerability, and Bioeffects of Alirocumab in Non-treatment Seeking Heavy Drinkers Alcohol Associated Liver Disease, Heavy Drinking Behavior | Phase 1 | 2021-10-19 |
| Enrolling By Invitation | Addictions Neuroclinical Assessment (ANA) Normal Physiology, Alcohol Use Disorder | — | 2021-08-12 |
| Completed | Effect of Acute Alcohol Intoxication on Neural Processes During Decisions to Engage in HIV Risk Behaviors Alcohol Use Disorder | Phase 1 | 2021-03-18 |
| Recruiting | COVID-19 Pandemic Impact on Alcohol (PIA) - A Natural History Study Alcohol Drinking, Alcohol-Related Disorders, Pandemic | — | 2020-06-03 |
| Terminated | HLAB-002 of ANS-6637 for Alcohol Use Disorder Alcohol Use Disorder | Phase 2 | 2019-10-08 |
| Recruiting | Nicotinic Receptor Genetic Variation and Alcohol Reward Alcohol Drinking | Phase 1 | 2019-06-10 |
| Completed | A Response Modulation Hypothesis of Socioemotional Processing Associated With Alcohol Use Disorder Healthy Volunteers, Alcohol Drinking Related Problems, Alcohol-Related Disorders | N/A | 2018-09-20 |
| Recruiting | Effects of Sucralose on Drug Absorption and Metabolism (The SweetMeds Study) Healthy Volunteers, Overweight | Phase 2 | 2018-04-05 |
| Completed | Dopaminergic Modulation of Brain Activation Using Simultaneous PET/Pharmacological MRI Normal Physiology | Phase 1 | 2018-01-29 |
| Completed | Ketogenic Diet (KD) in Alcoholism Alcoholism | N/A | 2017-10-24 |
| Completed | Brain Dopaminergic Signaling in Opioid Use Disorders Normal Physiology, Opioid Use Disorders | EARLY_Phase 1 | 2017-08-17 |
| Completed | Human Laboratory Study of Varenicline for Alcohol Use Disorder Alcohol Use Disorder | Phase 1 / Phase 2 | 2017-05-01 |
| Recruiting | Development Of Neuroimaging Methods To Assess The Neurobiology Of Addiction Normal Physiology | N/A | 2016-06-28 |
| Terminated | A Novel Compound for Alcoholism Treatment: A Translational Strategy - Part II Alcoholism | Phase 2 | 2016-06-15 |
| Completed | Title: Effect of Opioid Receptor Modulation on Alcohol Self-Administration and Neural Response to Alcohol Cues AUD | Phase 1 | 2016-06-08 |
| Completed | Brain Amyloid- Retention During Wakefulness and Following Emergence From Sleep in Healthy People Normal Physiology | EARLY_Phase 1 | 2016-05-02 |
| Withdrawn | Oxytocin in Alcohol Use Disorder Alcoholism | Phase 1 | 2016-03-08 |
| Completed | Study of Structural Imaging Chemically-Induced Disorders, Substance-Related Disorders, Mental Disorders | — | 2016-02-29 |
| Completed | Epi-Genetic Modulators of Fear Extinction in Alcohol Dependence Fear, Stress, Alcohol Dependence | — | 2015-08-13 |
| Completed | Human Brain Mapping of the Apparent Diffusion Coefficient (ADC) During Sleep and Wakefulness Brain Mapping | EARLY_Phase 1 | 2015-07-28 |
| Completed | Reliability of the Human Brain Connectome Normal Physiology | EARLY_Phase 1 | 2015-06-08 |
| Completed | HORIZANT (Gabapentin Enacarbil Extended-Release Tablets) for the Treatment of Alcohol Use Disorder Alcohol Use Disorder | Phase 2 | 2015-06-01 |
| Completed | Brain Inflammation and Function in Alcoholism Alcohol Use Disorder (AUD) | EARLY_Phase 1 | 2015-02-19 |
| Recruiting | NIAAA Natural History Protocol Alcohol Use Disorder | — | 2015-01-21 |
| Completed | Neural Substrates of Approach-Avoidance Conflict Alcoholism, fMRI, Rewarding Mediating System | — | 2014-07-23 |
| Recruiting | Characterization Imaging Instruments in Alcoholics and Non-Alcoholics Alcohol Dependence, Alcohol Drinking, Alcohol-Related Disorders | — | 2014-07-10 |
| Withdrawn | Traits Associated With Early Life Stress Among Treatment-Seeking Alcoholics Fear, Stress, Alcohol Dependence | — | 2014-06-19 |
| Terminated | Neuroimaging, Omega-3 and Reward in Adults With ADHD (NORAA) Trial Attention Deficit Disorder, Attention Deficit Hyerpactivity Disorder | Phase 2 | 2014-06-04 |
| Recruiting | Behavioral and Functional Task Development, Implementation, and Testing Alcohol Dependence, Alcohol Drinking, Alcoholism | N/A | 2014-05-28 |
| Completed | A Novel Compound for Alcoholism Treatment Alcoholism, Alcohol-Related Disorders, Alcohol Dependence | Phase 1 | 2014-01-03 |
| Completed | Genetic Effects on Dopamine Response to an Opiate Polymorphism-Genetic, Pain, Addiction | Phase 2 | 2013-06-13 |
| Completed | ABT-436 for Alcohol Dependence Alcohol Dependence, Alcohol Abuse, Alcohol Use Disorders | Phase 2 | 2013-02-01 |
| Completed | Ghrelin for Alcohol Use in Non-Treatment-Seeking Heavy Drinkers fMRI, Alcohol Drinking, Alcoholism | Phase 2 | 2012-12-13 |
| Completed | Baclofen for Treating Anxiety and Alcoholism Alcoholism, Alcohol Dependence, Alcohol Drinking Related Problems | Phase 2 | 2012-12-03 |
| Terminated | Role of Proinflammatory Signaling in Alcohol Craving Alcohol Dependence, Alcohol Drinking, Stress | Phase 2 | 2012-05-01 |
| Terminated | Measuring Effects of Alcohol on Brain Chemistry Healthy Volunteers | — | 2011-11-22 |
| Terminated | Genetics of the Acute Response to Alcohol in Social Drinkers Alcoholism, Genetics | Phase 1 | 2011-05-26 |
| Completed | Varenicline for Alcohol Dependence Alcoholism | Phase 2 | 2011-02-01 |
| Completed | National Epidemiologic Survey on Alcohol and Related Conditions-III Alcohol-Related Disorders | — | 2011-01-07 |
| Completed | Dietary Essential Fatty Acid Regulation of Omega-3 HUFA Metabolism; Satiety and Body Composition Weight Gain, Healthy Subjects, Obesity | N/A | 2010-11-12 |
| Completed | Corticotropin-Releasing Hormone Receptor 1 (CRH1) Antagonism in Anxious Alcoholics^ Alcohol-Related Disorders, Alcohol Dependence, Alcoholism | Phase 2 | 2010-10-01 |
| Completed | CRF1 Antagonist GSK561679 in Alcoholism Alcohol Dependence | Phase 2 | 2010-01-01 |
| Completed | Levetiracetam XR in Very Heavy Drinkers Alcoholism | Phase 2 | 2009-10-01 |
| Completed | The Effect of NK1R Antagonism on Alcohol Craving and PTSD Symptoms in Alcohol Dependent Patients With PTSD Alcoholism, Alcohol Dependence, Posttraumatic Stress Disorder | Phase 2 | 2009-05-01 |
| Completed | Computer-Assisted Self-Administration of Ethanol Alcoholic Intoxication | Phase 1 | 2008-10-29 |
| Completed | The Effect of Naltrexone on Alcohol Craving and on Brain Activity During Alcohol Infusion Alcohol Dependence, Alcoholism | EARLY_Phase 1 | 2008-04-22 |
| Completed | Modulation of Pharmacologically Induced Alcohol Craving in Recently Detoxified Alcoholics Alcoholism | Phase 2 | 2008-01-01 |
| Completed | Study of the Effectiveness of Quetiapine for the Treatment of Alcohol Dependency Alcoholism, Alcohol Abuse | Phase 2 | 2007-12-01 |
| Completed | Aripiprazole and Topiramate on Free-Choice Alcohol Use Alcohol Dependence | Phase 2 / Phase 3 | 2007-09-01 |
| Completed | OPRM1 A118G SNP, Alcohol Response, and Striatal Dopamine Alcoholism | — | 2006-11-16 |
| Completed | Stepped Care for Mandated College Students Alcohol Use | Phase 1 | 2006-10-01 |
| Completed | Psychoeducation for Hepatitis and Alcohol Behaviors Hepatitis C, Substance Abuse | N/A | 2006-09-01 |
| Completed | Medication and Counseling for Controlled Drinking (Project SMART) Alcohol-related Disorders, Alcohol Drinking, Alcoholism | Phase 3 | 2006-04-01 |
| Completed | Effect of LY686017 on Alcohol Craving Alcohol Dependence, Alcoholism | Phase 2 | 2006-03-01 |
| Completed | Individualized Treatment Program for Alcohol Problems Alcohol Dependence | Phase 1 | 2006-01-01 |
| Completed | Treatment of Patients With Alcoholism and Attention Deficit Disorder Alcoholism, Attention Deficit Disorder | Phase 4 | 2005-12-01 |
| Completed | Aftercare for Adolescents Treated for Alcohol Abuse and Dependence Alcohol Use Disorder | Phase 2 | 2005-11-01 |
| Completed | Alcoholism Assessment and Treatment Alcoholism, Alcohol Dependence, Alcohol Drinking Related Problems | — | 2005-03-16 |
| Unknown | Project RAP: Reaching Adolescents for Prevention Alcohol Related Morbidity, Alcohol Dependence | Phase 2 | 2004-10-01 |
| Unknown | Neurosteroids and Acute Alcohol Intoxication in Humans Alcohol Intoxication | Phase 1 | 2004-05-01 |
| Unknown | Alcohol Early Intervention for Freshmen Alcohol Abuse | N/A | 2004-01-01 |
| Completed | Rimonabant to Reduce Alcohol Consumption Healthy, Alcohol Drinking | Phase 2 | 2003-12-31 |
| Completed | PET Imaging of DHA Metabolism Healthy | — | 2003-12-12 |
| Completed | The Effect of Ethanol on Brain Activity Healthy | — | 2003-12-09 |
| Unknown | Brief Counseling to Reduce Injuries Among Emergency Department Patients Who Report Alcohol and Substance Use Alcohol Drinking, Marijuana Smoking | Phase 2 / Phase 3 | 2003-12-01 |
| Completed | Influence of Age and Sex on Alcohol Metabolism and Acute Responses Metabolism | — | 2003-09-29 |
| Completed | Hangover, Congeners, Sleep and Occupational Performance Sleep, Neurobehavioral Manifestations | Phase 2 | 2003-09-01 |
| Completed | Healthy Living as You Age Alcohol Related Disorders, Alcohol Drug Interactions | Phase 2 | 2003-08-01 |
| Completed | Blood Sample Donations to Study the Role of Genes in Pain Pain | — | 2002-12-10 |
| Completed | Role of Dopamine in Response to Alcohol Alcohol Consumption | — | 2002-11-01 |
| Completed | A Placebo-Controlled Trial of Memantine for Alcohol Dependence Alcohol Dependence (Primary Condition), Alcohol Abuse | Phase 2 | 2002-11-01 |
| Completed | Brain Function in Response to Motivational Stimuli Drug Dependence | — | 2002-10-12 |
| Completed | Bupropion as a Smoking Cessation Aid in Alcoholics Alcoholism, Smoking | Phase 4 | 2002-05-01 |
| Completed | Combined Pharmacotherapies for Alcoholism (Naltrexone/Ondansetron) Alcoholism | Phase 2 | 2001-09-01 |
| Completed | Comparing the Treatment of Alcohol Withdrawal Syndrome Using Gabapentin Versus Lorazepam Alcohol Withdrawal Syndrome(AWS) | Phase 2 | 2001-07-01 |
| Completed | Effect of Polyunsaturated Fatty Acids on Cardiovascular and Motor Responses Under Stress Healthy | Phase 1 | 2001-04-04 |
| Completed | Effect of Fluoxetine (Prozac) on Domestic Violence Domestic Violence | Phase 2 | 2001-02-22 |
| Completed | Serotonin in Alcoholism Alcoholism, Healthy | — | 2001-02-01 |
| Completed | Drug Treatment for Alcoholics With Bipolar Disorder Alcoholism, Bipolar Disorder | Phase 2 | 2000-10-01 |
| Completed | Drug Treatment for Depressed Alcoholics (Naltrexone/Fluoxetine) Alcoholism, Alcohol Dependence, Depression | Phase 4 | 2000-03-01 |
| Completed | The Effect of Positive and Negative Emotions on Brain Activity in Alcoholics and Nonalcoholics Alcoholism, Healthy | — | 1998-01-23 |
| Completed | Screening Evaluation for Studies of the National Institute on Alcohol Abuse and Alcoholism (NIAAA) Alcoholic Intoxication, Alcoholism, Healthy | — | 1997-10-02 |
| Completed | Activity of Essential Fatty Acid Elongation/Desaturation Pathway During Early Life in Human Infants, In Vivo Fatty Acid Metabolism | — | 1993-06-08 |
| Completed | Drug Treatment for Alcoholics With Post-Traumatic Stress Disorder Alcoholism, Post-Traumatic Stress Disorder | Phase 2 | — |
| Completed | Sertraline and Naltrexone for Alcohol Dependence Alcoholism | Phase 2 | — |
| Completed | Comparing Gabapentin and Lorazepam for Treating Alcohol Withdrawal Alcoholism | Phase 2 | — |
| Completed | Behavior and Naltrexone Treatment for Alcoholics Alcoholism | Phase 4 | — |
| Completed | Drug Therapy for Alcohol Detoxification Alcoholism | Phase 4 | — |
| Completed | Sertraline and Cognitive Therapy in Depressed Alcoholics Alcoholism, Depression | Phase 2 | — |
| Completed | Ondansetron Treatment for Alcoholism Alcoholism | Phase 2 | — |
| Completed | Use of Naltrexone in a Clinical Setting Alcoholism | Phase 4 | — |
| Completed | Naltrexone Treatment of Alcohol Dependence Alcoholism | Phase 4 | — |