| Not Yet Recruiting | National Collaborative Centre for Hepatic Regenerative Medicine (NC-CHRM): Evaluating Mesenchymal Stem-Cell (M NCT07075315 | Institute of Liver and Biliary Sciences, India | Phase 3 |
| Not Yet Recruiting | National Collaborative Centre for Hepatic Regenerative Medicine (NC-CHRM): Evaluating Mesenchymal Stem Cell Th NCT07131306 | Institute of Liver and Biliary Sciences, India | Phase 2 |
| Not Yet Recruiting | Efficacy and Safety of Early Initiation of Midodrine for Control and Prevention of Ascites and Its Related Com NCT07422948 | Institute of Liver and Biliary Sciences, India | N/A |
| Not Yet Recruiting | National Collaborative Centre for Hepatic Regenerative Medicine (NC-CHRM): Phase I Study on Safety and Efficac NCT07131540 | Institute of Liver and Biliary Sciences, India | Phase 1 |
| Recruiting | Risk Factors Affecting MSC Efficacy in ACLF Patients NCT07198854 | Sun Yat-sen University | — |
| Not Yet Recruiting | A-TANGO Phase 2 Study NCT06890039 | Yaqrit Ltd | Phase 2 |
| Completed | Pharmacokinetic Study on G1090N (Nitazoxanide) Capsules in Healthy Volunteers NCT07110441 | Genfit | Phase 1 |
| Active Not Recruiting | Phase I Trial of QH-1A Hybrid Bio-Artificial Liver With Ex Vivo Blood-Purifying MSCs in Acute-on-Chronic Liver NCT06996392 | Third Affiliated Hospital, Sun Yat-Sen University | Phase 1 |
| Not Yet Recruiting | Chinese Phase II Trail of AS1501 in Acute-on-chronic Liver Failure (ACLF) Patients NCT06916585 | Shenzhen Third People's Hospital | Phase 2 |
| Not Yet Recruiting | Umbilical Cord-derived Mesenchymal Stem Cell Infusion for Treating ACLF NCT06884904 | National Engineering Center of Cell Products | Phase 2 / Phase 3 |
| Recruiting | Comparison of Blood Products Required Using Two Different ROTEM Cut-offs Before Invasive Procedures in Cirrhos NCT06831565 | Institute of Liver and Biliary Sciences, India | N/A |
| Not Yet Recruiting | Efficacy and Safety of Continuous Infusion of Terlipressin vs Bolus Terlipressin in ACLF Patients With Acute E NCT06815770 | Institute of Liver and Biliary Sciences, India | Phase 2 / Phase 3 |
| Not Yet Recruiting | Comparison of Efficacy and Safety of Ceftazidime Avibactam Versus Extended Infusions of High Dose Meropenem in NCT06818565 | Institute of Liver and Biliary Sciences, India | N/A |
| Not Yet Recruiting | Goal Directed Ammonia Lowering Therapy in Hyperammonemic ACLF Patients With no Overt HE to Reduce Major Advers NCT06808009 | Institute of Liver and Biliary Sciences, India | N/A |
| Recruiting | Efficacy and Safety of Cytokine Adsorption and Plasma Exchange in Patients With ACLF and Sepsis NCT06562803 | Third Affiliated Hospital, Sun Yat-Sen University | N/A |
| Not Yet Recruiting | Safety and Efficacy of Continuous Infusion of Terlipressin With Norepinephrine Versus Norepinephrine Alone in NCT06556472 | Institute of Liver and Biliary Sciences, India | N/A |
| Recruiting | Feasibility Pilot Study to Evaluate the Safety and Performance of the MEX-CD1 Medical Device in ACLF NCT06340269 | Mexbrain | N/A |
| Recruiting | COOLEY- Study: aCute On chrOnic Liver failurE Using the cYtosorb Device NCT06079021 | University Hospital, Antwerp | N/A |
| Not Yet Recruiting | To Optimize Therapeutic Procedures of DPMAS in ACLF Patients: a Prospective, Sigle Arm and Multicenter Study NCT06377774 | Nanfang Hospital, Southern Medical University | — |
| Unknown | To Determine the Predictors of Reversibility for Acute-on-Chronic Liver Failure at 6-months. NCT06387160 | Institute of Liver and Biliary Sciences, India | — |
| Unknown | Acute hemodynamiC Response To Carvedilol Predicts Survival in ACLF Patients NCT06298656 | Institute of Liver and Biliary Sciences, India | — |
| Recruiting | Micro-encapsulated Hepatocyte Intraperitoneal Transplantation in Liver Failure Adults NCT05727722 | RenJi Hospital | Phase 1 |
| Not Yet Recruiting | An Open-label Randomized Controlled Trial Comparing the Role of Therapeutic Plasma-exchange in Ameliorating Se NCT06276907 | Institute of Liver and Biliary Sciences, India | N/A |
| Not Yet Recruiting | Acute on Chronic Liver Failure in Cirrhotic Patients at Assiut University Hospitals NCT06142968 | Assiut University | — |
| Unknown | Individual Nutrition Support in HBV-ACLF Patients at Nutrition Risk NCT06128421 | Third Affiliated Hospital, Sun Yat-Sen University | N/A |
| Unknown | Lactate Kinetics as a Predictor of Survival in ACLF With Septic Shock NCT06116305 | Institute of Liver and Biliary Sciences, India | — |
| Unknown | SALT for Treatment of Patients With Early ACLF NCT06069037 | RenJi Hospital | N/A |
| Unknown | To Study the Role of Plasma Von Willebrand Factor Antigen (vWF) to A Disintegrin-like and Metalloproteinase Wi NCT06066814 | Institute of Liver and Biliary Sciences, India | — |
| Recruiting | Human Umbilical Cord Mesenchymal Stem Cell Transplantation for The Treatment of Acute-on-Chronic Liver Failure NCT05985863 | Beijing 302 Hospital | Phase 1 / Phase 2 |
| Unknown | Prognostic Significance of Acute Change in Liver and Splenic Stiffness in Patients of Acute on Chronic Liver F NCT06069284 | Institute of Liver and Biliary Sciences, India | — |
| Withdrawn | Characterization of Metabolomic Fingerprints in Patients With Acute Liver Failure and Acute-on-chronic Liver F NCT05772585 | Assistance Publique - Hôpitaux de Paris | — |
| Withdrawn | The Safety and Efficacy of MSC-EVs in Acute/Acute-on-Chronic Liver Failure NCT05940610 | Third Affiliated Hospital, Sun Yat-Sen University | Phase 1 / Phase 2 |
| Unknown | Robotic vs. Laparoscopic vs. Open Living Donor Hepatectomy NCT06062706 | King Faisal Specialist Hospital & Research Center | — |
| Terminated | Efficacy, Safety and Tolerability of VS-01 in Adult Patients With Acute-on-Chronic Liver Failure and Ascites ( NCT05900050 | Genfit | Phase 2 |
| Unknown | Identification and Verification of Neutrophil Extracellular Trap Net Related Markers in Acute-on-chronic Liver NCT05909319 | First Affiliated Hospital of Wenzhou Medical University | — |
| Recruiting | F573 for Injection for the Treatment of Liver Injury/Failure NCT05689645 | Beijing Continent Pharmaceutical Co, Ltd. | Phase 2 |
| Recruiting | Efficacy and Safety of BMSCs (CG-BM1) for ACLF Patients NCT06740149 | Sun Yat-sen University | Phase 1 / Phase 2 |
| Recruiting | Study on Prognosis of Acute-on-chronic Liver Failure Complicated by Bacterial or Fungal Infection NCT06437067 | Qin Ning | — |
| Unknown | To Compare Relaxed Rotational Thromboelastometry Cut-offs With Standard Cut-offs for Guiding Blood Product Use NCT05672589 | Institute of Liver and Biliary Sciences, India | N/A |
| Unknown | Albumin Infusion in Inpatients With Decompensated Cirrhosis NCT05719051 | Ruijin Hospital | — |
| Completed | Intravenous BCAA for HE in ACLF (BCAA-HE-ACLF) NCT05700695 | Post Graduate Institute of Medical Education and Research, Chandigarh | Phase 1 |
| Unknown | Point-of-Care Echocardiography to Assess Impact of Dynamic Cardiac Function, Renal and Cardiac Biomarkers in C NCT05700708 | Post Graduate Institute of Medical Education and Research, Chandigarh | — |
| Unknown | Immune Profile, Neuronal Dysfunction, Metabolomics and Ammonia in Therapeutic Response of HE in ACLF NCT05421351 | Post Graduate Institute of Medical Education and Research, Chandigarh | — |
| Unknown | Role of Bilirubin Molecular Species in Hepatic Encephalopathy and Acute-on-chronic Liver Failure NCT05566548 | Medica Sur Clinic & Foundation | — |
| Recruiting | CytOSorb TreatMent Of Critically Ill PatientS Registry NCT05146336 | CytoSorbents, Inc | — |
| Unknown | Prognosis of Patients With Acute-on-chronic Liver Failure NCT05393453 | Xiangya Hospital of Central South University | — |
| Unknown | Efficacy and Safety of Avatrombopag for Treating TCP in HBV-ACLF Patients Receiving ALSS Treatment NCT05382013 | Third Affiliated Hospital, Sun Yat-Sen University | Phase 4 |
| Withdrawn | CytoSorb® in Patients With Acute on Chronic Liver Failure NCT05131230 | CytoSorbents Europe GmbH | — |
| Unknown | Acute Hemodynamic Response to Carvedilol in Predicting Survival in Acute on Chronic Liver Failure Patients - A NCT05180292 | Institute of Liver and Biliary Sciences, India | N/A |
| Unknown | Point-of-Care Echocardiography to Assess Impact of Dynamic Cardiac Function, Renal and Cardiac Biomarkers in C NCT05434286 | Post Graduate Institute of Medical Education and Research, Chandigarh | — |
| Unknown | TAK-242 in Patients With Acute Alcoholic Hepatitis NCT04620148 | Akaza Bioscience Ltd | Phase 2 |
| Completed | Goal-Directed Hemostatic Resuscitation Trial in ACLF Induced Coagulopathy NCT05124041 | Post Graduate Institute of Medical Education and Research, Chandigarh | N/A |
| Unknown | Cytokine Adsorption in Acute-on-chronic Liver Failure NCT05019352 | Dr. Alexander Supady | N/A |
| Unknown | Safety of UC-MSC Transfusion for ACLF Patients NCT04822922 | Hai Li | Phase 2 |
| Completed | Utility of Liver and Splenic Stiffness in Predicting Esophageal Varices in Patients With Acute on Chronic Live NCT04983108 | Institute of Liver and Biliary Sciences, India | — |
| Unknown | Transplantation for EASL-CLIF and APASL ACLF Patients: a Retrospective Cohort Study NCT05036031 | RenJi Hospital | — |
| Unknown | Incidence and Predictors of Bleeding Diathesis Development Due to DIC in Cirrhosis and ACLF Patients Undergoin NCT04960163 | Institute of Liver and Biliary Sciences, India | — |
| Recruiting | Liver Transplantation in Patients With CirrHosis and Severe Acute-on-Chronic Liver Failure: iNdications and ou NCT04613921 | European Foundation for Study of Chronic Liver Failure | — |
| Unknown | Risk Factors for Acute Kidney Injury in Critically Ill Patients With Acute-on-Chronic Liver Failure NCT04525625 | Institutul Clinic Fundeni | — |
| Recruiting | The Effects of Double Plasma Molecular Adsorption System in Acute on Chronic Liver Failure Patients NCT05030571 | Chulalongkorn University | N/A |
| Recruiting | Combination of DPMAS and Low Volume PE for Patients With HBV Related ACLF NCT04597164 | Third Affiliated Hospital, Sun Yat-Sen University | — |
| Unknown | Characterization and Pathogenesis of ACLF NCT04975490 | Johann Wolfgang Goethe University Hospital | — |
| Unknown | Role of Fecal Microbiota in Predicting Graft Rejection and Sepsis Among Recipients of Living Donor Liver Trans NCT04621812 | Institute of Liver and Biliary Sciences, India | — |
| Recruiting | Predicting Acute-on-Chronic Liver Failure After Surgical Intervention in Chronic Liver Disease NCT04578301 | University Hospital, Bonn | — |
| Unknown | 20% Albumin vs. Balanced Salt Solution as Resuscitation Fluid in Cirrhosis With Sepsis Induced Hypotension NCT05441878 | Post Graduate Institute of Medical Education and Research, Chandigarh | Phase 4 |
| Unknown | Efficacy of Albumin Plus Midodrine v/s Albumin Alone in Reducing Incidence of Paracentesis Induced Circulatory NCT04474262 | Institute of Liver and Biliary Sciences, India | N/A |
| Unknown | Efficacy of Addition of Fecal Microbiota Transplant (FMT) and Plasma Exchange to Tenofovir in Comparison to Mo NCT04431375 | Institute of Liver and Biliary Sciences, India | N/A |
| Completed | Efficacy of Early Terlipressin Plus Albumin Therapy in Comparison to Standard Treatment for HRS-AKI in Acute-o NCT04416282 | Institute of Liver and Biliary Sciences, India | N/A |
| Completed | Bowel Colonization With Multi-drug Resistant Bacterial Species in Hospitalized Patients With acute-on Chronic NCT04383106 | Institute of Liver and Biliary Sciences, India | — |
| Unknown | Early Postoperative CRRT After Liver Transplantation in ACLF Patients With Overt HE NCT04317222 | Third Affiliated Hospital, Sun Yat-Sen University | N/A |
| Recruiting | Long-term Prognosis of Patients With Hepatitis B Related Acute-on-chronic Liver Failure NCT04310787 | Third Affiliated Hospital, Sun Yat-Sen University | — |
| Completed | Volume Resuscitation in Cirrhosis With Sepsis Induced Hypotension NCT05059795 | Post Graduate Institute of Medical Education and Research, Chandigarh | — |
| Terminated | Study to Evaluate the Efficacy and Safety of HepaStem in Patients With Acute on Chronic Liver Failure (ACLF) NCT04229901 | Cellaion SA | Phase 2 |
| Unknown | Use of HA 330-II for Hemofiltration in Patients With ALF as a Bridge to Liver Transplantation . NCT04243655 | Asian Institute of Gastroenterology, India | Phase 4 |
| Unknown | Usefulness of the Variation of the CLIF-C ACLF Score in Patients With Acute on Chronic Liver Failure NCT04186572 | Hospital El Cruce | — |
| Unknown | RL-1 Novel Human-derived Bio-artificial Liver Treatment in Patients of HBV Related ACLF NCT04195282 | Third Affiliated Hospital, Sun Yat-Sen University | N/A |
| Completed | Anti-fungal Strategies in Acute-on-Chronic Liver Failure Patients NCT04157465 | Post Graduate Institute of Medical Education and Research, Chandigarh | N/A |
| Completed | Intravenous Branched Chain Amino Acids for Hepatic Encephalopathy in ACLF NCT04238416 | Post Graduate Institute of Medical Education and Research, Chandigarh | Phase 1 |
| Unknown | Plasma Exchange in Acute on Chronic Liver Failure NCT04051437 | Asian Institute of Gastroenterology, India | Phase 3 |
| Unknown | Efficacy and Safety of Hemoperfusion or Plasma Exchange Compared to Standard Medical Therapy in Patients With NCT04013113 | Institute of Liver and Biliary Sciences, India | N/A |
| Unknown | A Study of AARC Standards on Diagnosis and Treatment of Patients With HBV-ACLF in China (AARC China Study) NCT04054037 | Qin Ning | — |
| Unknown | Platelet Transfusion in Acute-on Chronic Liver Failure NCT04564651 | Nanfang Hospital, Southern Medical University | N/A |
| Unknown | Study to Evaluate Safety and Efficacy of LifeLiver in Acute or Acute-on-Chronic Liver Failure Patients NCT03882346 | HLB Cell Co., Ltd. | Phase 2 |
| Terminated | Allogeneic ABCB5-positive Stem Cells for Treatment of Acute-on-Chronic Liver Failure NCT03860155 | RHEACELL GmbH & Co. KG | Phase 1 / Phase 2 |
| Completed | Prediction Model Based on Computed Tomography Liver Volume for the Short-term Mortality in Hepatitis B Related NCT03977857 | First Affiliated Hospital Xi'an Jiaotong University | — |
| Recruiting | Three Types of Nucleotide/Nucleoside Analogues Treatment in HBV Related ACLF NCT03920618 | Third Affiliated Hospital, Sun Yat-Sen University | N/A |
| Terminated | Short-term Survival of Subjects With Acute-on-chronic Liver Failure After Plasma Exchange With Human Serum Alb NCT03702920 | Grifols Therapeutics LLC | Phase 3 |
| Completed | Study on the Optimal Strategy for Acute-on-chronic Liver Failure With Integrative Treatment NCT03577938 | Beijing 302 Hospital | N/A |
| Suspended | TRimetazidine for acUte on Chronic Liver Failure STudy NCT03737448 | Martin Pharmaceuticals | Phase 1 |
| Completed | Pattern of Acute on Chronic Liver Failure in Patient With HCV Related Chronic Liver Disease NCT03456518 | Assiut University | — |
| Unknown | Platelet Transfusion in HBV-related acute-on Chronic Liver Failure NCT03713489 | Nanfang Hospital, Southern Medical University | N/A |
| Withdrawn | Safety Study of Stemchymal® in Acute Liver Failure NCT03629015 | Steminent Biotherapeutics Inc. | Phase 1 |
| Unknown | Efficacy of Albumin Therapy With Standard Medical Treatment (SMT) as Compared to Standard Medical Treatment (S NCT03754400 | Institute of Liver and Biliary Sciences, India | N/A |
| Completed | A Multicenter Prospective Study of Application of Platelet Mapping in Acute-on-chronic-liver Failure in China NCT04119973 | Nanfang Hospital, Southern Medical University | — |
| Unknown | PEG3350 in ACLF With Hepatic Encephalopathy NCT03987893 | Post Graduate Institute of Medical Education and Research, Chandigarh | Phase 4 |
| Terminated | HepaStem Long-Term Safety Registry NCT03343756 | Cellaion SA | — |
| Completed | Global Coagulation Assessment in Cirrhosis and ACLF NCT04332484 | Post Graduate Institute of Medical Education and Research, Chandigarh | — |
| Unknown | Mesenchymal Stem Cell Transplantation for Acute-on-chronic Liver Failure NCT03668171 | Xijing Hospital of Digestive Diseases | N/A |
| Completed | Safety and Performance Trial of DIALIVE Liver Dialysis Device in Acute On Chronic Liver Failure Patients NCT03065699 | Yaqrit Ltd | N/A |
| Completed | Acute-On-Chronic Liver Failure in Zagazig University Hospitals NCT03184636 | Zagazig University | — |
| Withdrawn | To Assess the Efficacy of High-Volume Plasma Exchange and GCSF Versus GCSF Alone in Patients of Acute on Chron NCT03162419 | Institute of Liver and Biliary Sciences, India | N/A |
| Completed | Phase II Safety Study of 2 Dose Regimens of HepaStem in Patients With ACLF NCT02946554 | Cellaion SA | Phase 2 |
| Completed | Exploring Biomarkers Predicting the Outcome of Acute-on-chronic Liver Failure NCT02965560 | First Affiliated Hospital of Zhejiang University | — |
| Terminated | To Study the Influence of GCSF on Natural History of Acute On Chronic Liver Failure After the Acute Phase NCT02788240 | Institute of Liver and Biliary Sciences, India | N/A |
| Completed | Randomized Controlled Trial Comparing the Efficacy and Safety of FMT in Hepatitis B Reactivation Leads to Acut NCT02689245 | Institute of Liver and Biliary Sciences, India | N/A |
| Completed | Granulocyte Colony Stimulating Factor (G-CSF) to Treat Acute-on-chronic Liver Failure NCT02669680 | University of Leipzig | N/A |
| Completed | To Compare the Response Rate of Noradrenaline vs. Terlipressin in Hepatorenal Syndrome in Patients With Acute NCT02573727 | Institute of Liver and Biliary Sciences, India | N/A |
| Completed | Efficacy of Nonselective Beta Blocker vs Placebo in Patients With Acute-on-chronic Liver Failure With Small/ n NCT02583698 | Institute of Liver and Biliary Sciences, India | N/A |
| Completed | MERTK Signalling in Monocytes/Macrophages in Patients With Liver Disease NCT04116242 | University Hospital, Basel, Switzerland | — |
| Unknown | Assessment of Coagulation Abnormalities in Acute on Chronic Liver Failure Patients Using Thromboelastography NCT02757170 | All India Institute of Medical Sciences | Phase 4 |
| Completed | Incidence And Outcome Of Paracentesis Induced Circulatory Dysfunction In Acute-On-Chronic Liver Failure. NCT02467348 | Institute of Liver and Biliary Sciences, India | N/A |
| Completed | Effect of Goal Directed Ammonia Lowering Therapy in Acute on Chronic Liver Failure Patients With Hepatic Encep NCT02321371 | Institute of Liver and Biliary Sciences, India | N/A |
| Completed | Assessment of Coagulation Profile and Haematopoietic Responses in Patients With Acute-on-chronic Liver Failure NCT02307409 | Institute of Liver and Biliary Sciences, India | — |
| Completed | Role of 13C Methacetin Breath Test in Predicting Prognosis Among Patients With Acute or Acute on Chronic Liver NCT01946360 | Institute of Liver and Biliary Sciences, India | N/A |
| Unknown | Evaluation of Role of Transient Elastography (Fibroscan) in Differentiating Patients of Acute Severe Viral Hep NCT01866072 | Sir Ganga Ram Hospital | — |
| Unknown | Granulocyte Colony Stimulating Factor(G-CSF) Therapy for Patients With ACLF NCT01036932 | Govind Ballabh Pant Hospital | N/A |
| Completed | Randomized Controlled Trial of Tenofovir in Patients of Reactivation of Hepatitis B Presenting as Acute on Chr NCT01074645 | Govind Ballabh Pant Hospital | Phase 4 |