NCT02965560

Exploring Biomarkers Predicting the Outcome of Acute-on-chronic Liver Failure

A Study on Biomarkers Predicting the Outcome of Acute-on-chronic Liver Failure

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 350 (actual)
• Sponsor: First Affiliated Hospital of Zhejiang University · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

Acute-on-chronic liver failure (ACLF) is an ailment with high incidence of multiorgan failure (MOF) and consequent mortality. Systemic inflammation and susceptibility to infection are characteristic pathophysiological features. Prostaglandin E2 (PGE2) could subdue systemic inflammation and alleviate liver injury in mice model. However, there are no studies evaluating PGE2 as a predictor of early mortality.This study is designed to investigate whether plasma PGE2 and its receptors are associated with development of MOF and predict short-term mortality in patients with acute-on-chronic liver failure. By the way, we will also measure several other potential predictive factors (C-reactive protein,severe hyponatremia, Second infections,Diabetes mellitus,High density lipoprotein,interleukin-10,serum bile acids,ferritin,the neutrophil to lymphocyte ratio,soluable urokinase plasminogen activator receptor,vWF-Ag levels and FVIII-to-PC ratios).

Conditions

• Acute-On-Chronic Liver Failure
• Cirrhosis and Chronic Liver Disease

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	plasma suPAR, PGE2 measurement. Other biomarkers were just recorded from clinical laboratory.

Timeline

• Start date: 2016-10-10
• Primary completion: 2017-10-10
• Completion: 2018-06-01
• First posted: 2016-11-16
• Last updated: 2018-06-06