Trials / Completed
CompletedNCT04332484
Global Coagulation Assessment in Cirrhosis and ACLF
Clinical Validation of the Use of Global Coagulation Tests Like Thromboelastography and Sonoclot in Liver Disease - A Prospective Observational Study.
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 142 (actual)
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh · Academic / Other
- Sex
- All
- Age
- 18 Years – 65 Years
- Healthy volunteers
- Accepted
Summary
Background: Patients with cirrhosis and acute-on-chronic liver failure (ACLF) may have bleeding complications which can lead to increased mortality. Standard coagulation tests (SCTs) like prothrombin time, platelet count and activated partial thromboplastin do not accurately depict in vivo coagulation profile. Point-of-care viscoelastic coagulation testing devices like thrombo-elastography (TEG) and Sonoclot may be better for guiding patient management. Methods: This prospective observational study compared and validated the point of care (POC) tests and SCTs in 70, 72 and 25 persons with ACLF, decompensated cirrhosis and healthy controls respectively.
Conditions
Timeline
- Start date
- 2018-01-01
- Primary completion
- 2019-08-31
- Completion
- 2019-08-31
- First posted
- 2020-04-02
- Last updated
- 2020-04-02
Locations
1 site across 1 country: India
Source: ClinicalTrials.gov record NCT04332484. Inclusion in this directory is not an endorsement.