| Not Yet Recruiting | High-volume Versus Standard Volume Plasma Exchange in Patients With Acute Liver Failure With Cerebral Edema NCT06515145 | Institute of Liver and Biliary Sciences, India | N/A |
| Not Yet Recruiting | Transcriptional Analysis of Mechanisms in Liver Failure and Sepsis NCT07131969 | University of Cambridge | — |
| Enrolling By Invitation | Continuous Renal Replacement Therapy Intensity in Hyperammonemia NCT06987604 | Hospital de Clinicas de Porto Alegre | N/A |
| Recruiting | Standard Volume vs. High Volume Plasma Exchange in Pediatric Acute Liver Failure NCT06831643 | Institute of Liver and Biliary Sciences, India | N/A |
| Not Yet Recruiting | Etiology and Prognostic Analysis of Acute Liver Failure in Chinese Children NCT06778941 | liyumei | — |
| Active Not Recruiting | Role of N-Acetylcysteine in Non-Acetaminophen-Induced Acute Liver Failure NCT06872372 | Lahore General Hospital | N/A |
| Not Yet Recruiting | Daily Versus Alternate Day Plasma Exchange in Wilson Disease With Acute Liver Failure in Children NCT06698991 | Institute of Liver and Biliary Sciences, India | N/A |
| Completed | miroliverELAP® for the Treatment of Acute Liver Failure: A Phase 1 Trial NCT06285253 | Miromatrix Medical Inc. | Phase 1 |
| Enrolling By Invitation | Clinical Study of Pediatric Acute Liver Failure NCT06893042 | Fansen Zeng | — |
| Recruiting | ALSS - DPMAS and Therapeutic Plasma Exchange (TPE), Its Effect on Primary Coagulation, Inflammation and the Fu NCT07329036 | Institute for Clinical and Experimental Medicine | N/A |
| Completed | Plasma Exchange for Amanita Toxin-induced Acute Liver Failure NCT06187220 | Hannover Medical School | — |
| Withdrawn | The Safety and Efficacy of MSC-EVs in Acute/Acute-on-Chronic Liver Failure NCT05940610 | Third Affiliated Hospital, Sun Yat-Sen University | Phase 1 / Phase 2 |
| Withdrawn | Characterization of Metabolomic Fingerprints in Patients With Acute Liver Failure and Acute-on-chronic Liver F NCT05772585 | Assistance Publique - Hôpitaux de Paris | — |
| Unknown | Robotic vs. Laparoscopic vs. Open Living Donor Hepatectomy NCT06062706 | King Faisal Specialist Hospital & Research Center | — |
| Withdrawn | Cardiac Risk Assessment Using Standard of Care Versus CTA and Heart Flow FFRct NCT04089969 | Corewell Health East | N/A |
| Recruiting | F573 for Injection for the Treatment of Liver Injury/Failure NCT05689645 | Beijing Continent Pharmaceutical Co, Ltd. | Phase 2 |
| Not Yet Recruiting | Hepatocyte Microbeads for Acute Liver Failure NCT05491135 | King's College Hospital NHS Trust | Phase 1 / Phase 2 |
| Recruiting | CytOSorb TreatMent Of Critically Ill PatientS Registry NCT05146336 | CytoSorbents, Inc | — |
| Active Not Recruiting | Evaluation of Cardiac Function in Acutely Decompensated Cirrhosis NCT05413083 | Clinical Hospital Colentina | — |
| Recruiting | TReatment for ImmUne Mediated PathopHysiology NCT04862221 | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Phase 2 |
| Unknown | To Evaluate the Safety and Efficacy of Preemptive Administration of Continuous Renal Replacement Therapy in Pa NCT04991259 | Institute of Liver and Biliary Sciences, India | N/A |
| Unknown | Outcomes Using MARS for Patients With ALF NCT05594953 | Methodist Health System | — |
| Unknown | Role of Fecal Microbiota in Predicting Graft Rejection and Sepsis Among Recipients of Living Donor Liver Trans NCT04621812 | Institute of Liver and Biliary Sciences, India | — |
| Withdrawn | To Assess the Role of Fecal Microbiota Transplant in Acute Liver Failure NCT03363022 | Institute of Liver and Biliary Sciences, India | N/A |
| Unknown | Study to Evaluate Safety and Efficacy of LifeLiver in Acute or Acute-on-Chronic Liver Failure Patients NCT03882346 | HLB Cell Co., Ltd. | Phase 2 |
| Withdrawn | Safety Study of Stemchymal® in Acute Liver Failure NCT03629015 | Steminent Biotherapeutics Inc. | Phase 1 |
| Completed | High-Volume Plasma Exchange Versus Standard Medical Treatment in Patients With Acute Liver Failure NCT02718079 | Institute of Liver and Biliary Sciences, India | N/A |
| Active Not Recruiting | Biomarkers in Liver Failure NCT02833064 | University of Edinburgh | — |
| Completed | 13C-Methacetin Breath Test for the Prediction of Outcome in in ALI or ALF NCT02786836 | University of Texas Southwestern Medical Center | Phase 2 / Phase 3 |
| Completed | Central Venous Catheter Colonisation Among Critically Ill Patients in Intensive Care Units NCT03270774 | Makerere University | — |
| Completed | High Volume Plasma Exchange in Children With Acute Liver Failure and Acute on Chronic Liver Failure NCT02719210 | Institute of Liver and Biliary Sciences, India | N/A |
| Completed | One Way to Diagnose Hepatic Insufficiency the First Postoperative Day After Resection: Prospective Cohort Stud NCT04570800 | Castilla-La Mancha Health Service | — |
| Terminated | Safety and Efficacy of the ELAD System (ELAD) to Treat Acute Liver Failure (ALF) NCT01875874 | Vital Therapies, Inc. | Phase 2 |
| Completed | Role of Hypertonic Saline Versus Mannitol in the Management of Raised Intracranial Pressure in Patients With A NCT02460510 | Institute of Liver and Biliary Sciences, India | N/A |
| Completed | Role of 13C Methacetin Breath Test in Predicting Prognosis Among Patients With Acute or Acute on Chronic Liver NCT01946360 | Institute of Liver and Biliary Sciences, India | N/A |
| Terminated | Pharmacokinetic and Pharmacodynamic Study of IDN-6556 in ACLF NCT01937130 | Conatus Pharmaceuticals Inc. | Phase 2 |
| Completed | Spectrum, Profile and Outcome of Infections in Patients With Cirrhosis and/ or Acute on Chronic Liver Failure NCT01872767 | Institute of Liver and Biliary Sciences, India | — |
| Completed | Safety Study of Ornithine Phenylacetate to Treat Patients With Acute Liver Failure/Severe Acute Liver Injury NCT01548690 | William Lee | Phase 2 |
| Unknown | Molecular Adsorbent Recirculating System (MARS®) in Hypoxic Hepatitis NCT01690845 | Medical University of Vienna | Phase 2 |
| Completed | Liver Function After Intravenous Methylprednisolone Administration NCT03667157 | Medical University of Warsaw | Phase 4 |
| Unknown | Breath Test for Patients With Acute Liver Disease for Early Detection of the Need for Transplant or Recovery NCT01435421 | Hadassah Medical Organization | — |
| Suspended | Longitudinal Study of Mitochondrial Hepatopathies NCT01148550 | Arbor Research Collaborative for Health | — |
| Withdrawn | Registry Protocol for Tracking Trial Subjects After VTI-206 Study Completion NCT01452295 | Vital Therapies, Inc. | Phase 2 / Phase 3 |
| Terminated | Study of N-Acetylcysteine in Acute Liver Failure (ALF) NCT00896025 | University of Texas Southwestern Medical Center | Phase 4 |
| Completed | The Effect of Prometheus (R) Liver Support Dialysis on Cerebral Metabolism in Acute Liver Failure NCT00655304 | Rigshospitalet, Denmark | N/A |
| Completed | Indocyangreen Elimination in Cirrhosis and Acute Liver Failure NCT00245310 | Heidelberg University | — |
| Unknown | Therapeutic Efficacy of L-Ornithine L-Aspartate Infusion in Patients With Acute Liver Failure NCT00470314 | All India Institute of Medical Sciences | Phase 2 |
| Completed | Hypothermia to Prevent High Intracranial Pressure in Patients With Acute Liver Failure NCT00670124 | Rigshospitalet, Denmark | N/A |
| Completed | Prevention of Recurrent Hepatitis B After Liver Transplantation NCT00059267 | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | — |
| Completed | A Multi-Center Group to Study Acute Liver Failure in Children NCT00986648 | University of Pittsburgh | — |
| Completed | N-acetylcysteine in Non-Acetaminophen Pediatric Acute Liver Failure NCT00248625 | University of Pittsburgh | Phase 3 |
| Completed | Randomized Study of Acetylcysteine in Patients With Acute Liver Failure Not Caused by Acetaminophen NCT00004467 | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Phase 3 |
| Completed | A Study of the Effect of Plasmaexchange in Patients With Acute Liver Failure NCT00950508 | Rigshospitalet, Denmark | N/A |
| Completed | A Multi-Center Trial to Study Acute Liver Failure in Adults NCT00518440 | William Lee | — |
| No Longer Available | Emergency Use of OCR-002 in Acute Liver Failure (ALF) NCT01634230 | Ocera Therapeutics, Inc. | — |