Trials / Completed
CompletedNCT02718079
High-Volume Plasma Exchange Versus Standard Medical Treatment in Patients With Acute Liver Failure
High-Volume Plasma Exchange Versus Standard Medical Treatment in Patients With Acute Liver Failure-A Prospective Randomized Pilot Trial
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 40 (actual)
- Sponsor
- Institute of Liver and Biliary Sciences, India · Academic / Other
- Sex
- All
- Age
- 12 Years – 75 Years
- Healthy volunteers
- Not accepted
Summary
The study will be conducted on patients admitted to Department of Hepatology from Jan 2016 to Jan 2018 at Institute of Liver \& Biliary Sciences, New Delhi. Study group will comprise of patients with acute liver failure (ALF) who have no option for liver transplant (due to any reason) or have contraindications for liver transplant or have no prospective living donor and will be assessed for enrollment in the trial.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| BIOLOGICAL | Plasma Exchange | |
| OTHER | Management of cerebral edema/intracranial hypertension: | |
| OTHER | Transfer to Intensive Care Unit | |
| DRUG | Prophylactic Antibiotics | |
| OTHER | Intubation of trachea | |
| OTHER | Administration of mannitol or 3% saline for severe elevation of Intra Cranial Pressure | |
| OTHER | Volume Replacement | |
| OTHER | Pressor Support | |
| DRUG | N-acetyl-L-cysteine | |
| OTHER | Correction of metabolic parameters | |
| DIETARY_SUPPLEMENT | Correction of nutrition |
Timeline
- Start date
- 2016-12-30
- Primary completion
- 2018-10-08
- Completion
- 2018-10-18
- First posted
- 2016-03-24
- Last updated
- 2019-11-20
Locations
1 site across 1 country: India
Source: ClinicalTrials.gov record NCT02718079. Inclusion in this directory is not an endorsement.